Hypoglycemic agent 3
Hypoglycemic agent 3 (Compound H26), a derivative of corosolic acid, exhibits lipid-lowering and significant hypoglycemic effects and can be used as a hypoglycemic agent. Hypoglycemic agent 3 inhibits insulin resistance by targeting MCCC1 and can be used in the study of type 2 diabetes.
For research use only. We do not sell to patients.
- Formula: C32H51NO5
- Molecular Weight:529.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Hypoglycemic agent 3 (Compound H26) (40-320 μM; 24 h) shows no significant cytotoxicity in HepG2 cells[1]. Hypoglycemic agent 3 (20-40 μM) suppresses insulin resistance primarily by increasing MCCC1 in HepG2 cells[1].Hypoglycemic agent 3 (20 μM; 1 h) significantly inhibits the increase in glucose production induced by glucosamine (18 mM; 18 h) (HY-B1125) in HepG2 cells[1]. Hypoglycemic agent 3 (2.5-20 μM; 1 h) can activate PI3K-AKT and inhibit NF-κB signaling pathway in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2
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Concentration:2.5, 10, 20 μM
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Incubation Time:1 h
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Result:Ehanced the phosphorylation levels of KT and GSK3β. Sgnificantly increased the expression of IκBα, suggesting that H26 may inhibit the activation of NF-κB.
Chemical Information
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Molecular Weight 529.75
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Formula C32H51NO5
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SMILES
O=C(O)CNC([C@]12CC[C@@H](C)[C@H](C)[C@@]1([H])C3=CCC4[C@@]5(C)C[C@@H](O)[C@H](O)C(C)(C)C5CC[C@@]4(C)[C@]3(C)CC2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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