2. Cell Cycle/DNA Damage Cytoskeleton
  3. Topoisomerase Integrin DNA/RNA Synthesis
  4. iRGD-CPT

iRGD-CPT is a conjugate of iRGD and camptothecin that is covalently coupled through a heterobifunctional linker. iRGD-CPT has anticancer activity in vitroandin vivo. iRGD-CPT can be used for the study of colon cancer.

For research use only. We do not sell to patients.

iRGD-CPT

iRGD-CPT Chemical Structure

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iRGD-CPT Related Antibodies

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Description

iRGD-CPT is a conjugate of iRGD and camptothecin that is covalently coupled through a heterobifunctional linker. iRGD-CPT has anticancer activity in vitroandin vivo. iRGD-CPT can be used for the study of colon cancer[1].

Cellular Effect
Cell Line Type Value Description References
HT-29 IC50
0.35 μM
Compound: iRGD-CPT
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38128233]
SW480 IC50
0.32 μM
Compound: iRGD-CPT
Cytotoxicity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38128233]
Molecular Weight

1781.90

Formula

C75H100N18O27S3
SMILES

O=C(CC1SC[C@H](NC(C)=O)C(N[C@@H]2C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(NCC(N3CCC[C@H]3C(N[C@H](C(N[C@@H](CSSC2)C(O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N(CCC(NOCCOCCOCCCC(O[C@]4(CC)C(OCC5=C4C=C6N(CC7=CC8=CC=CC=C8N=C76)C5=O)=O)=O)=O)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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iRGD-CPT Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iRGD-CPTTopoisomeraseIntegrinDNA/RNA SynthesisColon cancerAnticancerCamptotheciniRGDInhibitorinhibitorinhibit

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