1. Cell Cycle/DNA Damage
  2. CDK
  3. IV-361

IV-361 

Cat. No.: HY-139011
Handling Instructions

IV-361 is an orally active and selective CDK7 inhibitor (Ki≤50 nM). IV-361 has anti-cancer activity (US20190256531A1).

For research use only. We do not sell to patients.

IV-361 Chemical Structure

IV-361 Chemical Structure

CAS No. : 2055741-39-2

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Description

IV-361 is an orally active and selective CDK7 inhibitor (Ki≤50 nM). IV-361 has anti-cancer activity (US20190256531A1)[1].

IC50 & Target[1]

CDK7

≤50 nM (Ki)

CDK2

≥1000 nM (Ki)

In Vitro

IV-361 has less inhibition on CDK2 (Ki≥1000 nM) or PLK1 (Ki≥5000 nM)[1].
IV-361 exhibits excellent IL-2 and IL-17 production inhibitory activity (all IC50≤100 nM) in periphery blood mononuclear cell (PBMC)[1].
IV-361 exhibits excellent HCT-116 cell growth inhibitory activity (GI50≤100 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

IV-361 (25 mg/kg/day; orally) exhibits 46% or more rate of suppression of tumor volume in female BALB nude mice with HCT-116[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

457.62

Formula

C₂₃H₃₂FN₅O₂Si

CAS No.
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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IV-361
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HY-139011
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