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製品番号: HY-111356

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IIIM-290

IIIM-290 is a potent and oral CDK inhibitor with IC₅₀s of 90 and 94 nM for CDK2/A and CDK9/T1.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2213468-64-3
分子式: C₂₃H₂₁Cl₂NO₅
分子量:462.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

IIIM-290 構造式

CAS 番号: 2213468-64-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IIIM-290 is a potent and oral CDK inhibitor with IC₅₀s of 90 and 94 nM for CDK2/A and CDK9/T1.

IC₅₀ & Target^[1]

CDK2/A

90 nM (IC₅₀)

CDK9/T1

94 nM (IC₅₀)

CDK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	6 μM Compound: 11d	Growth inhibition of human 786-0 cells after 48 hrs by MTT assay Growth inhibition of human 786-0 cells after 48 hrs by MTT assay	[PMID: 29370702]
A-431	GI₅₀	8 μM Compound: 11d	Growth inhibition of human A431 cells after 48 hrs by MTT assay Growth inhibition of human A431 cells after 48 hrs by MTT assay	[PMID: 29370702]
A549	GI₅₀	4 μM Compound: 11d	Growth inhibition of human A549 cells after 48 hrs by MTT assay Growth inhibition of human A549 cells after 48 hrs by MTT assay	[PMID: 29370702]
BT-549	GI₅₀	5 μM Compound: 11d	Growth inhibition of human BT549 cells after 48 hrs by MTT assay Growth inhibition of human BT549 cells after 48 hrs by MTT assay	[PMID: 29370702]
Caco-2	GI₅₀	7 μM Compound: 11d	Growth inhibition of human Caco2 cells after 48 hrs by MTT assay Growth inhibition of human Caco2 cells after 48 hrs by MTT assay	[PMID: 29370702]
COLO 205	GI₅₀	7 μM Compound: 11d	Growth inhibition of human COLO205 cells after 48 hrs by MTT assay Growth inhibition of human COLO205 cells after 48 hrs by MTT assay	[PMID: 29370702]
DU-145	GI₅₀	5 μM Compound: 11d	Growth inhibition of human DU145 cells after 48 hrs by MTT assay Growth inhibition of human DU145 cells after 48 hrs by MTT assay	[PMID: 29370702]
HCT-116	GI₅₀	5 μM Compound: 11d	Growth inhibition of human HCT116 cells after 48 hrs by MTT assay Growth inhibition of human HCT116 cells after 48 hrs by MTT assay	[PMID: 29370702]
HCT-116	GI₅₀	9.32 μM Compound: 1e; IIIM-290	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37302342]
HEK293	GI₅₀	>100 μM Compound: 1e; IIIM-290	Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37302342]
HEK293	GI₅₀	22 μM Compound: 11d	Growth inhibition of human HEK293 cells after 48 hrs by MTT assay Growth inhibition of human HEK293 cells after 48 hrs by MTT assay	[PMID: 29370702]
HEK293	IC₅₀	>50 μM Compound: 11d	Inhibition of [3H]-astemizole binding to human ERG expressed in HEK293 cell membranes by scintillation counting method Inhibition of [3H]-astemizole binding to human ERG expressed in HEK293 cell membranes by scintillation counting method	[PMID: 29370702]
HL-60	GI₅₀	0.9 μM Compound: 11d	Growth inhibition of human HL60 cells after 48 hrs by MTT assay Growth inhibition of human HL60 cells after 48 hrs by MTT assay	[PMID: 29370702]
HOP-62	GI₅₀	7 μM Compound: 11d	Growth inhibition of human HOP62 cells after 48 hrs by MTT assay Growth inhibition of human HOP62 cells after 48 hrs by MTT assay	[PMID: 29370702]
HOP-92	GI₅₀	3 μM Compound: 11d	Growth inhibition of human HOP92 cells after 48 hrs by MTT assay Growth inhibition of human HOP92 cells after 48 hrs by MTT assay	[PMID: 29370702]
LOX IMVI	GI₅₀	4 μM Compound: 11d	Growth inhibition of human LOXIMVI cells after 48 hrs by MTT assay Growth inhibition of human LOXIMVI cells after 48 hrs by MTT assay	[PMID: 29370702]
MCF7	GI₅₀	4 μM Compound: 11d	Growth inhibition of human MCF7 cells after 48 hrs by MTT assay Growth inhibition of human MCF7 cells after 48 hrs by MTT assay	[PMID: 29370702]
MDA-MB-231	GI₅₀	4 μM Compound: 11d	Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 29370702]
MDA-MB-468	GI₅₀	4 μM Compound: 11d	Growth inhibition of human MDA-MB-468 cells after 48 hrs by MTT assay Growth inhibition of human MDA-MB-468 cells after 48 hrs by MTT assay	[PMID: 29370702]
MIA PaCa-2	GI₅₀	1 μM Compound: 11d	Growth inhibition of human MIAPaCa2 cells after 48 hrs by MTT assay Growth inhibition of human MIAPaCa2 cells after 48 hrs by MTT assay	[PMID: 29370702]
MIA PaCa-2	GI₅₀	1.94 μM Compound: 1e; IIIM-290	Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37302342]
MOLT-4	GI₅₀	0.5 μM Compound: 11d	Growth inhibition of human MOLT4 cells after 48 hrs by MTT assay Growth inhibition of human MOLT4 cells after 48 hrs by MTT assay	[PMID: 29370702]
NCI-H226	GI₅₀	4 μM Compound: 11d	Growth inhibition of human NCI-H226 cells after 48 hrs by MTT assay Growth inhibition of human NCI-H226 cells after 48 hrs by MTT assay	[PMID: 29370702]
NCI-H522	GI₅₀	5 μM Compound: 11d	Growth inhibition of human NCI-H522 cells after 48 hrs by MTT assay Growth inhibition of human NCI-H522 cells after 48 hrs by MTT assay	[PMID: 29370702]
OVCAR-3	GI₅₀	8 μM Compound: 11d	Growth inhibition of human OVCAR3 cells after 48 hrs by MTT assay Growth inhibition of human OVCAR3 cells after 48 hrs by MTT assay	[PMID: 29370702]
OVCAR-4	GI₅₀	9 μM Compound: 11d	Growth inhibition of human OVCAR4 cells after 48 hrs by MTT assay Growth inhibition of human OVCAR4 cells after 48 hrs by MTT assay	[PMID: 29370702]
OVCAR-5	GI₅₀	7 μM Compound: 11d	Growth inhibition of human OVCAR5 cells after 48 hrs by MTT assay Growth inhibition of human OVCAR5 cells after 48 hrs by MTT assay	[PMID: 29370702]
PANC-1	GI₅₀	4 μM Compound: 11d	Growth inhibition of human PANC1 cells after 48 hrs by MTT assay Growth inhibition of human PANC1 cells after 48 hrs by MTT assay	[PMID: 29370702]
PC-3	GI₅₀	3 μM Compound: 11d	Growth inhibition of human PC3 cells after 48 hrs by MTT assay Growth inhibition of human PC3 cells after 48 hrs by MTT assay	[PMID: 29370702]
T47D	GI₅₀	6 μM Compound: 11d	Growth inhibition of human T47D cells after 48 hrs by MTT assay Growth inhibition of human T47D cells after 48 hrs by MTT assay	[PMID: 29370702]

化学情報

CAS 番号 2213468-64-3
分子量 462.32
分子式 C₂₃H₂₁Cl₂NO₅
SMILES

OC1=C2C(OC(/C=C/C3=C(Cl)C=CC=C3Cl)=CC2=O)=C([C@]4([H])[C@H](O)CN(C)CC4)C(O)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Bharate SB, et al. Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor. J Med Chem. 2018 Feb 22;61(4):1664-1687. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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IIIM-290

CDK アイソフォーム固有の製品をすべて表示