製品番号: HY-15322

PRT062607

(別名: P505-15; PRT-2607; BIIB-057)

4 Cited Publications

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

PRT062607 (P505-15; PRT-2607) is an orally active ATP-competitive Syk inhibitor with an IC₅₀ value of 1 nM, and exhibits at least 80-fold selectivity over other kinases. PRT062607 blocks B cell antigen receptor-mediated activation, Fcε receptor 1-mediated basophil degranulation and microglial phagocytosis, and induces caspase-dependent apoptosis and microglial death. PRT062607 inhibits tumor growth and peripheral nerve injury-induced mechanical allodynia, and prevents neuronal loss. PRT062607 can be used in research related to rheumatoid arthritis, chronic lymphocytic leukemia, non-Hodgkin's lymphoma, neurodegenerative diseases and neuropathic pain.

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純度: 99.38%
CAS 番号: 1370261-96-3
分子式: C₁₉H₂₃N₉O
分子量:393.45

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

PRT062607 構造式

CAS 番号: 1370261-96-3

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生物活性
- 製品説明
- Cellular Effect
- 体外実験
- Parmacokinetics
- 体内実験
- 臨床実験
化学情報
Publications (4)
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
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生物活性

製品説明

Caspase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Bone marrow cell	IC₅₀	5853 nM Compound: 1, BIB-057	Cytotoxicity against C57BL/6 mouse bone marrow cells assessed as growth inhibition preincubated for 4 days followed by [3H]-thymidine addition measured after 5 hrs by betaplate counting analysis Cytotoxicity against C57BL/6 mouse bone marrow cells assessed as growth inhibition preincubated for 4 days followed by [3H]-thymidine addition measured after 5 hrs by betaplate counting analysis	[PMID: 25633741]
Bone marrow cell	IC₅₀	5853 nM Compound: 1, BIIB-057	Inhibition of IL3 dependent proliferation in C57/B16 mouse bone marrow cells using [3H]thymidine by liquid scintillation counting Inhibition of IL3 dependent proliferation in C57/B16 mouse bone marrow cells using [3H]thymidine by liquid scintillation counting	[PMID: 24726806]
CHO	IC₅₀	8600 nM Compound: 1, BIB-057	Inhibition of human ERG expressed in CHO cells by automated Qpatch clamp assay Inhibition of human ERG expressed in CHO cells by automated Qpatch clamp assay	[PMID: 25633741]
Jurkat	IC₅₀	1805 nM Compound: 1, BIB-057	Inhibition of ZAP70 in anti-CD3 stimulated human Jurkat T cells assessed as SLP76 phosphorylation at Y128 preincubated for 30 mins followed by anti-CD3 stimulation measured after 2 mins by FACS analysis Inhibition of ZAP70 in anti-CD3 stimulated human Jurkat T cells assessed as SLP76 phosphorylation at Y128 preincubated for 30 mins followed by anti-CD3 stimulation measured after 2 mins by FACS analysis	[PMID: 25633741]
Ramos	IC₅₀	0.223 μM Compound: 2	Inhibition of SYK in human Ramos cells Inhibition of SYK in human Ramos cells	[PMID: 23350847]
Ramos	IC₅₀	0.223 μM Compound: PRT062607	Cytotoxicity against human Ramos cells Cytotoxicity against human Ramos cells	[PMID: 23151054]
Ramos	IC₅₀	178 nM Compound: 1, BIIB-057	Inhibition of Syk in anti IgM-stimulated human Ramos cells assessed as BLNK phosphorylation by cellular assay Inhibition of Syk in anti IgM-stimulated human Ramos cells assessed as BLNK phosphorylation by cellular assay	[PMID: 24726806]

体外実験

PRT062607 potently inhibits purified Syk in FRET kinase assays containing 15 and 100 μM ATP, with IC₅₀ values of 2.1 and 6 nM^[1].
PRT062607 (0.01-2.5 μM; 1.5 h) specifically inhibits BCR-mediated Syk-dependent BLNK Tyr84 phosphorylation in SUDHL4 cells, with an IC₅₀ of 0.16-0.4 μM^[1].
PRT062607 potently inhibits BCR-mediated Syk-dependent ERK Tyr204 phosphorylation in Ramos cells with an IC₅₀ of 50 nM; at concentrations up to 2 μM, this compound does not affect non-Syk-dependent, PMA-mediated ERK phosphorylation^[1].
PRT062607 (P505-15) (0-6 μM; 3 days) selectively inhibits the proliferation of Syk-dependent TEL-Syk Ba/F3 cells, with an IC₅₀ of 120 nM^[1].
PRT062607 (0-4 μM; 40 min) potently inhibits Syk-dependent BCR-mediated ERK Tyr204 phosphorylation in human whole blood B cells, with a mean IC₅₀ of 0.27 μM^[1].
PRT062607 (0-4 μM; 16.5 h) potently inhibits Syk-dependent BCR-mediated B cell activation (CD69 upregulation) in human whole blood, with a mean IC₅₀ of 0.28 μM^[1].
PRT062607 (0-4 μM; 1.25 h) potently inhibits Syk-dependent FcεR1-mediated basophil degranulation in human whole blood, with a mean IC₅₀ of 0.15 μM^[1].
PRT062607 (2 μM; 30 min) inhibits anti-IgM-induced autophosphorylation of SYK in Ramos human non-Hodgkin's lymphoma B cells^[2].
PRT062607 (0.02-2 μM; 30 min) inhibits anti-IgM-induced phosphorylation of ERK and AKT in the human non-Hodgkin's lymphoma B cell line Ramos in a concentration-dependent manner, with an IC₅₀ of approximately 50 nM, and achieves complete inhibition at 250 nM^[2].
PRT062607 (1-3 μM; 72 hours) induces apoptosis in human non-Hodgkin's lymphoma B cell lines SU-DHL4, SU-DHL6 and Ramos with functional BCR signaling, but exerts no such effect in BCR/BLNK-deficient Toledo/Karpas-422 cell lines or primary human B cells; PRT062607 (1 μM; 24 hours) induces apoptosis in SU-DHL6 cells mixed with whole blood, while primary B cells remain unaffected^[2].
PRT062607 (0.01-1 μM; 30 min) concentration-dependently inhibits BCR-induced AKT phosphorylation in primary human chronic lymphocytic leukemia (CLL) cells, with complete inhibition achieved at concentrations ranging from 0.3 to 1 μM^[2].
PRT062607 (10 nM-10 μM; 72 h) reduces cell viability by 36% in primary human chronic lymphocytic leukemia (CLL) samples, including high-risk samples with 17p deletion, 11q deletion or unmutated IgVh, with an IC₅₀ < 3 μM in responsive samples^[2].
PRT062607 (10 nM-10 μM; 72 h) acts synergistically with fludarabine to reduce the viability of primary human chronic lymphocytic leukemia (CLL) cells, and a fludarabine hyporeactive effect is observed at lower fludarabine concentrations^[2].
PRT062607 (10 μM; 3 d) completely blocks LPS (HY-D1056)-induced neuronal loss as well as spontaneous age-related neuronal loss in primary rat cerebellar neuron-glia cultures^[3].
PRT062607 (10 μM; 3 d) significantly depletes microglia and induces microglial death in primary rat cerebellar neuron-glia cultures without LPS treatment, but does not deplete microglia in LPS-treated cultures^[3].
PRT062607 (10 μM; 24 h) induces significant microglial necrosis and apoptotic cell death, and reduces total cell density in primary rat cortical microglia^[3].
PRT062607 (10 μM; overnight) reduces the phagocytosis of 5 μm microspheres by primary rat cortical microglia under both resting and LPS-activated conditions^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

SUDHL4 human non-Hodgkin's lymphoma B cell line
Concentration:

0.01, 0.025, 0.064, 0.16, 0.4, 1 and 2.5 μM
Incubation Time:

1 h (pretreatment); 30 min (stimulation)
Result:

Inhibited BCR-mediated BLNK Tyr84 phosphorylation in a concentration-dependent manner, with an IC₅₀ range of 0.16-0.4 μM.
Did not inhibit BCR-mediated Syk Tyr352 phosphorylation at concentrations up to 2.5 μM.

Cell Viability Assay^[1]

Cell Line:

Ba/F3 mouse pro-B cell line stably expressing TEL-Syk
Concentration:

0.074, 0.22, 0.66, 2 and 6 μM
Incubation Time:

3 days
Result:

Selectively inhibited proliferation of the TEL-Syk-expressing Ba/F3 cell line with an IC₅₀ of 120 ± 5 nM.
Did not inhibit proliferation of Ba/F3 cell lines expressing TEL-JAK1, TEL-JAK2, TEL-JAK3, TEL-Tyk2, or TEL-Zap70 at 2 μM.

Western Blot Analysis^[2]

Cell Line:

Ramos human non-Hodgkin lymphoma B-cell line
Concentration:

2 μM
Incubation Time:

30 minutes (preincubation)
Result:

Significantly reduced SYK autophosphorylation at the Y525/526 sites compared to stimulated, untreated cells.

Apoptosis Analysis^[2]

Cell Line:

SU-DHL4, SU-DHL6, Ramos, Toledo, and Karpas-422 human non-Hodgkin lymphoma B-cell lines; primary human B-cells
Concentration:

1 μM (24 h whole blood experiment); 1 μM, 3 μM (72 h apoptosis assay)
Incubation Time:

24 h (whole blood experiment); 72 h (apoptosis assay)
Result:

Induced apoptosis (measured by active caspase-3 cleavage) in BCR-signaling competent cell lines SU-DHL4, SU-DHL6, and Ramos, but not in BCR-deficient Toledo or BLNK-deficient Karpas-422 lines.
Induced apoptosis in SU-DHL6 cells mixed with heparinized human whole blood, while primary B-cells did not undergo apoptosis.

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_min	AUC	C_max
Mice^[2]	10 mg/kg	p.o.	/	1.5 h	45 nM	738 ng·h/mL	/
Mice^[2]	15 mg/kg	p.o.	/	1.5 h	69 nM	1671 ng·h/mL	893 nM
Mice^[2]	20 mg/kg	p.o.	/	4.0 h	102 nM	3191 ng·h/mL	1484 nM
Mice^[2]	1 mg/kg	i.v.	3.9 h	/	/	/	/

体内実験

PRT062607 (5-30 mg/kg; p.o.; twice daily; for 10-15 days) dose-dependently inhibits joint inflammation in collagen antibody-induced arthritis models of mice and rats^[1].
PRT062607 (15 mg/kg; p.o.; twice daily; 5 days) significantly inhibits B cell receptor (BCR)-induced splenomegaly and marginal B cell zone expansion in mice^[2].
PRT062607 (10-20 mg/kg; p.o.; twice daily; 5 weeks) significantly inhibits the growth of Ramos NHL tumors in NOD/SCID mice^[2].
PRT062607 (4.5 mg per rat; intrathecal injection; single administration) significantly reverses mechanical allodynia induced by spared nerve injury in rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female)^[1]
Dosage:

5 mg/kg; 15 mg/kg; 30 mg/kg
Administration:

p.o.; b.i.d.; 10 days
Result:

Produced average paw inflammation score inhibitions of 12%, 44%, and 87% respectively, with corresponding average plasma concentrations of 0.38, 0.95, and 1.47 μM.
Significantly reduced blinded histopathology scores and hind paw ankle thickness in the 15 and 30 mg/kg dose groups compared with vehicle controls.
Rendered joint structure indistinguishable from normal naive mice at 30 mg/kg, with no intra-articular neutrophils, fibrin, or synovial tissue damage.

Animal Model:

Lewis (female, 7-week-old)^[1]
Dosage:

5 mg/kg; 10 mg/kg; 15 mg/kg
Administration:

p.o.; b.i.d.; 15 days
Result:

Completely suppressed inflammation in 7 of 8 rats at 15 mg/kg, resulting in a mean inflammation score of 0.63 with an average plasma concentration of 1.34 μM.
Produced a significantly efficacious reduction in inflammation at 10 mg/kg with an average plasma concentration of 0.72 μM.
Significantly reduced blinded histopathology scores and hind paw ankle thickness in the 15 mg/kg dose group compared with vehicle controls.
Rendered joint morphology indistinguishable from normal naive rats at 15 mg/kg, with no inflammatory infiltrate, synovial hyperplasia, or cartilage erosion.

Animal Model:

Balb/c (5 per group)^[2]
Dosage:

15 mg/kg
Administration:

p.o.; twice daily; 5 days
Result:

Reduced average spleen weight from ~0.17 g to ~0.12 g.
Corrected the expansion of the marginal B-cell zone observed in vehicle-treated anti-IgD mice.

Animal Model:

NOD/SCID (15 per group)^[2]
Dosage:

10 mg/kg; 15 mg/kg; 20 mg/kg
Administration:

p.o.; twice daily; until study termination
Result:

Reduced average tumor weight.
Sustained steady-state tumor concentrations above 63 nM (10 mg/kg), 176 nM (15 mg/kg), and 325 nM (20 mg/kg) over the entire dosing interval.
Increased lymphocyte counts in 15 mg/kg group; no reductions in any leukocyte subsets across all dose groups.

Animal Model:

Sprague Dawley (male and female, 7-8 weeks old, n=6 per sex per treatment group)^[4]
Dosage:

4.5 mg
Administration:

intrathecal injection; single injection
Result:

Significantly reversed SNI-induced mechanical pain hypersensitivity in both male and female rats.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 1370261-96-3
性状 Solid
分子量 393.45
分子式 C₁₉H₂₃N₉O
Color White to off-white
SMILES

NC(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(N4N=CC=N4)=C3)=O
別名

P505-15; PRT-2607; BIIB-057
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (4)

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Nat Commun

Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]

2026 Feb 12;17(1):1214. PMID: 41680175
Cell Death Dis

Activation of AKT via a dual mechanism enhances the susceptibility of melanoma cells to glucose deprivation. [Abstract]

2025 Aug 7;16(1):595. PMID: 40774947
Proc Natl Acad Sci U S A

Endocytosis triggers V-ATPase-SYK-mediated priming of cGAS activation and innate immune response. [Abstract]

2022 Oct 25;119(43):e2207280119. PMID: 36252040
Int J Ophthalmol

NADPH oxidase 2 plays a protective role in experimental Aspergillus fumigatus keratitis in mice through killing fungi and limiting the degree of inflammation. [Abstract]

2022 Jul 18;15(7):1044-1052. PMID: 35919314

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (254.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5416 mL

12.7081 mL

25.4162 mL

5 mM

0.5083 mL

2.5416 mL

5.0832 mL

10 mM

0.2542 mL

1.2708 mL

2.5416 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (12.71 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (6.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
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The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

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参考文献

[1]. Coffey G, et al. Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis. J Pharmacol Exp Ther. 2012;340(2):350-359. [Content Brief]

[2]. Spurgeon SE, et al. The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia. J Pharmacol Exp Ther. 2013;344(2):378-387. [Content Brief]

[3]. Birkle TJY, et al. Syk inhibitors protect against microglia-mediated neuronal loss in culture. Front Aging Neurosci. 2023;15:1120952. Published 2023 Mar 15. [Content Brief]

[4]. Ghazisaeidi S, et al. Conserved transcriptional programming across sex and species after peripheral nerve injury predicts treatments for neuropathic pain. Br J Pharmacol. 2023;180(21):2822-2836. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5416 mL	12.7081 mL	25.4162 mL	63.5405 mL
	5 mM	0.5083 mL	2.5416 mL	5.0832 mL	12.7081 mL
	10 mM	0.2542 mL	1.2708 mL	2.5416 mL	6.3540 mL
	15 mM	0.1694 mL	0.8472 mL	1.6944 mL	4.2360 mL
	20 mM	0.1271 mL	0.6354 mL	1.2708 mL	3.1770 mL
	25 mM	0.1017 mL	0.5083 mL	1.0166 mL	2.5416 mL
	30 mM	0.0847 mL	0.4236 mL	0.8472 mL	2.1180 mL
	40 mM	0.0635 mL	0.3177 mL	0.6354 mL	1.5885 mL
	50 mM	0.0508 mL	0.2542 mL	0.5083 mL	1.2708 mL
	60 mM	0.0424 mL	0.2118 mL	0.4236 mL	1.0590 mL
	80 mM	0.0318 mL	0.1589 mL	0.3177 mL	0.7943 mL
	100 mM	0.0254 mL	0.1271 mL	0.2542 mL	0.6354 mL

PRT062607

4 Cited Publications

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PRT062607

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Anti-Blood Cancer Compound Library

Neurodegenerative Disease-related Compound Library

Heterocyclic Compound Library

Cell Death Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Posttranslational Modification Library

MedChemExpress（MCE）の使用を引用している文献 PRT062607

Caspase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (4)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

PRT062607

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Anti-Blood Cancer Compound Library

Neurodegenerative Disease-related Compound Library

Heterocyclic Compound Library

Cell Death Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Posttranslational Modification Library

MedChemExpress（MCE）の使用を引用している文献 PRT062607

Caspase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (4)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

PRT062607 関連分類

製品番号: HY-15322