AG-12286
AG-12286 is a pan-CDK inhibitor with an IC50 value of 2 nM against cdk1/cyclin B, 6 nM against cdk2/cyclin E, and 12 nM against cdk4/cyclin D. AG-12286 is 1000-fold more selective for the CDK family than for PKC. AG-12286 can be used in cancer research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 223784-75-6
- 分子式: C16H12F2N4O3S2
- 分子量:410.42
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cdk1/cyclin B 2 nM (IC50) |
CDK2/cyclinE 6 nM (IC50) |
CDK4/cyclin D 12 nM (IC50) |
AG-12286 acts as a pan-cyclin-dependent kinase inhibitor, potently inhibiting cdk1/cycB (IC50 = 2 nM), cdk2/cycE (IC50 = 6 nM), and cdk4/cycD (IC50 = 12 nM) while showing >1000X selectivity over PKC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 223784-75-6
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分子量 410.42
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分子式 C16H12F2N4O3S2
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SMILES
O=C(C1=C(F)C=CC=C1F)C2=C(N)N=C(NC3=CC=C(S(=O)(N)=O)C=C3)S2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AG-12286 関連分類
HY-183854 関連分類
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