Apoptotic agent-2
Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research.
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- CAS 番号: 2482310-18-7
- 分子式: C25H16ClN7S
- 分子量:481.96
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Bax |
Caspase 3 |
Bcl-2 |
Apoptotic agent-2 (compound 14b) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2, MCF-7 and WI-38 (normal human cells) cells with IC50 values of 1.96, 1.12, 2.38 and 107.5 µM, respectively[1].
Apoptotic agent-2 (compound 14b) (1.12 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 10.92 folds and 9.7 folds, respectively, and decreases the level of Bcl-2 by 3.3 folds[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG-2 cells
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Concentration:1.12 μM
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Incubation Time:24 hours
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Result:The percentage of cells in the G2-M phase increased while the percentage of cells in G0-G1 phase and S phase decreased.
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Cell Line:HepG-2 cells
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Concentration:1.12 μM
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Incubation Time:24 hours
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Result:Increased the early apoptosis ratio from 0.69% to 5.17% and increased the late apoptosis ratio from 0.32% to 12.11%.
化学情報
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CAS 番号 2482310-18-7
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分子量 481.96
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分子式 C25H16ClN7S
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SMILES
CC1=C(/N=N/C2=CC=C(Cl)C=C2)SC(N/N=C3C4=C(C5=NC6=CC=CC=C6N=C5\3)C=CC=C4)=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Apoptotic agent-2 関連分類
HY-147928 関連分類
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