Apoptotic agent-3
Based on 1 Customer Validation
Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and activation of the Caspase 3 pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used for cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.19%
- CAS 番号: 2482310-23-4
- 分子式: C31H21N5OS
- 分子量:511.60
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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生物活性
製品説明
IC50 & Target
[1]|
Caspase 3 |
Bcl-2 |
Bax |
体外実験
Apoptotic agent-3 (compound 15f) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2 MCF-7 and WI-38 cells (normal human cells) with IC50 values of 1.62, 1.46, 2.04 and 117.9 µM, respectively[1].
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Apoptotic agent-3 (compound 15f) (24 hours) (1.46 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 11.53 folds and 10 folds, respectively, and decreases the level of Bcl-2 by 3.8 folds[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG-2 cells
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Concentration:1.46 μM
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Incubation Time:24 hours
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Result:The percentage of cells in the G2-M phase increased while the percentage of cells in G1 phase and S phase decreased.
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Cell Line:HepG-2 cells
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Concentration:1.46 μM
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Incubation Time:24 hours
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Result:Increased the early apoptosis ratio from 0.69% to 8.25% and increased the late apoptosis ratio from 0.32% to 13.05%.
化学情報
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CAS 番号 2482310-23-4
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性状 Solid
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分子量 511.60
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分子式 C31H21N5OS
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Color Orange to reddish brown
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SMILES
COC1=CC=C(C2=CS/C(N2C3=CC=CC=C3)=N/N=C4C5=C(C6=NC7=CC=CC=C7N=C6\4)C=CC=C5)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (276 KB)
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- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Apoptotic agent-3 関連分類
HY-147929 関連分類
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