DS02312223
Based on 1 Customer Validation
DS02312223 (D223) is a molecular glue that promotes the binding of RAS to PI3Kα, with a Kd of 0.76 μM for p110α. DS02312223 increases the binding affinity between GTP-bound KRAS (KRAS-GMPPNP) and p110α by nearly three orders of magnitude (KD = 0.017 μM). DS02312223 stimulates the translocation of GLUT4 to the plasma membrane. DS02312223 promotes glucose uptake in the absence of insulin. DS02312223 can be used in diabetes research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.24%
- CAS 番号: 2253733-45-6
- 分子式: C29H32FN5O5S
- 分子量:581.66
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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PI3Kα |
GLUT4 |
DS02312223 (10-10000 nM) stimulates concentration-dependent GLUT4 translocation in differentiated L6-GLUT4 myc myotubes in the absence of insulin[1].
DS02312223 (1 μM; 5 min) enhances the interaction between PI3Kα and RRAS2 in serum-starved L6-GLUT4myc myotubes[1].
DS02312223 binds directly to p110α (KD = 0.76 μM) and increases the binding affinity between GTP-bound KRAS (KRAS-GMPPNP) and p110α by nearly three orders of magnitude (KD = 0.017 μM), but does not bind KRAS-GMPPNP or induce binding between KRAS-GDP and p110α[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L6-GLUT4 myc myotubes
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Concentration:1 μM
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Incubation Time:5 min
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Result:Increased the association of PI3Kα with RRAS2, whereas the inactive compound D484 had no effect.
化学情報
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CAS 番号 2253733-45-6
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性状 Solid
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分子量 581.66
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分子式 C29H32FN5O5S
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Color White to off-white
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SMILES
CC(C)(OC(NCCOCCOC1=C(C=CC=C1)C2=C3SC=CC3=C(N=N2)NC4=C(C=C(C=C4)CC(N)=O)F)=O)C
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別名
D223
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (171.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7192 mL | 8.5961 mL | 17.1922 mL | 42.9804 mL |
| 5 mM | 0.3438 mL | 1.7192 mL | 3.4384 mL | 8.5961 mL | |
| 10 mM | 0.1719 mL | 0.8596 mL | 1.7192 mL | 4.2980 mL | |
| 15 mM | 0.1146 mL | 0.5731 mL | 1.1461 mL | 2.8654 mL | |
| 20 mM | 0.0860 mL | 0.4298 mL | 0.8596 mL | 2.1490 mL | |
| 25 mM | 0.0688 mL | 0.3438 mL | 0.6877 mL | 1.7192 mL | |
| 30 mM | 0.0573 mL | 0.2865 mL | 0.5731 mL | 1.4327 mL | |
| 40 mM | 0.0430 mL | 0.2149 mL | 0.4298 mL | 1.0745 mL | |
| 50 mM | 0.0344 mL | 0.1719 mL | 0.3438 mL | 0.8596 mL | |
| 60 mM | 0.0287 mL | 0.1433 mL | 0.2865 mL | 0.7163 mL | |
| 80 mM | 0.0215 mL | 0.1075 mL | 0.2149 mL | 0.5373 mL | |
| 100 mM | 0.0172 mL | 0.0860 mL | 0.1719 mL | 0.4298 mL |
DS02312223 関連分類
HY-W1126235 関連分類
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