NFE2L2 - NFE2 like bZIP transcription factor 2 Gene
Also Known as NRF2; HEBP1; Nrf-2; IMDDHH
生物種: Homo sapiens
About NFE2L2
This gene has 65 transcripts (splice variants), 218 orthologues, 3 paralogues and is associated with 97 phenotypes. Ubiquitous expression in esophagus (RPKM 93.8), thyroid (RPKM 52.1) and 24 other tissues.
Summary
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]
NFE2L2 Products (8)
| mRNA | Protein | Name |
|---|---|---|
| NM_001145412.3 | NP_001138884.1 | nuclear factor erythroid 2-related factor 2 isoform 2 |
| NM_006164.5 | NP_006155.2 | nuclear factor erythroid 2-related factor 2 isoform 1 |
| NM_001313900.1 | NP_001300829.1 | nuclear factor erythroid 2-related factor 2 isoform 2 |
| NM_001313904.1 | NP_001300833.1 | nuclear factor erythroid 2-related factor 2 isoform 6 |
| NM_001313903.2 | NP_001300832.1 | nuclear factor erythroid 2-related factor 2 isoform 5 |
| NM_001145413.3 | NP_001138885.1 | nuclear factor erythroid 2-related factor 2 isoform 3 |
| NM_001313901.1 | NP_001300830.1 | nuclear factor erythroid 2-related factor 2 isoform 2 |
| NM_001313902.2 | NP_001300831.1 | nuclear factor erythroid 2-related factor 2 isoform 4 |
NFE2L2 Protein Structure
bZIP_Maf: bZIP Maf transcription factor (469 - 558)
- 0
- 100
- 200
- 300
- 400
- 500
- 605 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
nuclear factor erythroid 2-related factor 2 |
|
NFE2L2 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
NFE2L2 | Q16236 | APEX1 | Homo sapiens | P27695 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | APEX1 | Homo sapiens | P27695 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | IRF1 | Homo sapiens | P10914 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | IRF1 | Homo sapiens | P10914 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CERS2 | Homo sapiens | Q96G23 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CERS2 | Homo sapiens | Q96G23 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ELF3 | Homo sapiens | P78545 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ELF3 | Homo sapiens | P78545 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ELF3 | Homo sapiens | P78545 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ETV6 | Homo sapiens | P41212 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ETV6 | Homo sapiens | P41212 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ETV6 | Homo sapiens | P41212 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ETV6 | Homo sapiens | P41212 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ETS2 | Homo sapiens | P15036 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ETS2 | Homo sapiens | P15036 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | BRPF3 | Homo sapiens | Q9ULD4 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | BRPF3 | Homo sapiens | Q9ULD4 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CFAP299 | Homo sapiens | Q6V702 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CFAP299 | Homo sapiens | Q6V702 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | MAFK | Homo sapiens | O60675 | 21988832 | |
|
Intra
|
NFE2L2 | Q16236 | MAFK | Homo sapiens | O60675 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | TEF | Homo sapiens | Q10587 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | TEF | Homo sapiens | Q10587 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | TEF | Homo sapiens | Q10587 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | TEF | Homo sapiens | Q10587 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | FOSB | Homo sapiens | P53539 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | FOSB | Homo sapiens | P53539 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | FOSB | Homo sapiens | P53539 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | FOSB | Homo sapiens | P53539 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | SP140 | Homo sapiens | Q13342 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | SP140 | Homo sapiens | Q13342 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | SP140 | Homo sapiens | Q13342 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CREBL2 | Homo sapiens | O60519 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CREBL2 | Homo sapiens | O60519 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CREBL2 | Homo sapiens | O60519 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CREBL2 | Homo sapiens | O60519 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | REL | Homo sapiens | Q04864 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | REL | Homo sapiens | Q04864 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | REL | Homo sapiens | Q04864 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | REL | Homo sapiens | Q04864 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | BTRC | Homo sapiens | Q9Y297 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | NFAT5 | Homo sapiens | O94916 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | NFAT5 | Homo sapiens | O94916 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | NFAT5 | Homo sapiens | O94916 | 32911434 | |
|
Cross
|
NFE2L2 | Q16236 | Rara | Mus musculus | P11416 | 28777872 | |
|
Intra
|
NFE2L2 | Q16236 | KPNA2 | Homo sapiens | P52292 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | KPNA2 | Homo sapiens | P52292 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ARPC2 | Homo sapiens | O15144 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ARPC2 | Homo sapiens | O15144 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ARPC2 | Homo sapiens | O15144 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ARPC2 | Homo sapiens | O15144 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | FBXW11 | Homo sapiens | Q9UKB1 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | TBP | Homo sapiens | P20226 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | TBP | Homo sapiens | P20226 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | TBP | Homo sapiens | P20226 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | TBP | Homo sapiens | P20226 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | EIF3J | Homo sapiens | O75822 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | EIF3J | Homo sapiens | O75822 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | EIF3J | Homo sapiens | O75822 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | EIF3J | Homo sapiens | O75822 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | FOSL2 | Homo sapiens | P15408 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | FOSL2 | Homo sapiens | P15408 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | FOSL2 | Homo sapiens | P15408 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | FOSL2 | Homo sapiens | P15408 | 32911434 | |
|
Cross
|
NFE2L2 | Q16236 | Pml | Mus musculus | Q60953 | 28777872 | |
|
Intra
|
NFE2L2 | Q16236 | ETV1 | Homo sapiens | P50549 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ETV1 | Homo sapiens | P50549 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ETV1 | Homo sapiens | P50549 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | GATA1 | Homo sapiens | P15976 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | GATA1 | Homo sapiens | P15976 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | KPNA4 | Homo sapiens | O00629 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | KPNA4 | Homo sapiens | O00629 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | KPNA4 | Homo sapiens | O00629 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | GRB2 | Homo sapiens | P62993 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | GRB2 | Homo sapiens | P62993 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | RARA | Homo sapiens | P10276 | 18048326 | |
|
Intra
|
NFE2L2 | Q16236 | RARA | Homo sapiens | P10276 | 18048326 | |
|
Intra
|
NFE2L2 | Q16236 | MAP2K6 | Homo sapiens | P52564 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | MAP2K6 | Homo sapiens | P52564 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | MAP2K6 | Homo sapiens | P52564 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | MAP2K6 | Homo sapiens | P52564 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ATF4 | Homo sapiens | P18848 | 23661758 | |
|
Intra
|
NFE2L2 | Q16236 | ATF4 | Homo sapiens | P18848 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ATF4 | Homo sapiens | P18848 | 26700459 | |
|
Intra
|
NFE2L2 | Q16236 | ATF4 | Homo sapiens | P18848 | 26700459 | |
|
Intra
|
NFE2L2 | Q16236 | STAT3 | Homo sapiens | P40763 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | STAT3 | Homo sapiens | P40763 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | STAT3 | Homo sapiens | P40763 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | STAT3 | Homo sapiens | P40763 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CASP7 | Homo sapiens | P55210 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CASP7 | Homo sapiens | P55210 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CREBZF | Homo sapiens | Q9NS37 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CREBZF | Homo sapiens | Q9NS37 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CREBZF | Homo sapiens | Q9NS37 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CREBZF | Homo sapiens | Q9NS37 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ARFIP2 | Homo sapiens | P53365 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ARFIP2 | Homo sapiens | P53365 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ETV4 | Homo sapiens | P43268 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ETV4 | Homo sapiens | P43268 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ETV4 | Homo sapiens | P43268 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ETV4 | Homo sapiens | P43268 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ATF3 | Homo sapiens | P18847 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ATF3 | Homo sapiens | P18847 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ATF3 | Homo sapiens | P18847 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ATF3 | Homo sapiens | P18847 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | COPS7A | Homo sapiens | Q9UBW8 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | MAFG | Homo sapiens | O15525 | 34591642 | |
|
Intra
|
NFE2L2 | Q16236 | MAFG | Homo sapiens | O15525 | 23661758 | |
|
Intra
|
NFE2L2 | Q16236 | MAFG | Homo sapiens | O15525 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | MAFG | Homo sapiens | O15525 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | PMF1 | Homo sapiens | Q6P1K2 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | MAFF | Homo sapiens | Q9ULX9 | 34591642 | |
|
Intra
|
NFE2L2 | Q16236 | MAFF | Homo sapiens | Q9ULX9 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | TNNT1 | Homo sapiens | P13805 | 25416956 | |
|
Intra
|
NFE2L2 | Q16236 | TNNT1 | Homo sapiens | P13805 | 25416956 | |
|
Intra
|
NFE2L2 | Q16236 | TNNT1 | Homo sapiens | P13805 | 31515488 | |
|
Intra
|
NFE2L2 | Q16236 | ELK1 | Homo sapiens | P19419 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | ELK1 | Homo sapiens | P19419 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | RELA | Homo sapiens | Q04206 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | RELA | Homo sapiens | Q04206 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | RELA | Homo sapiens | Q04206 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | RELA | Homo sapiens | Q04206 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CEBPG | Homo sapiens | P53567 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CEBPG | Homo sapiens | P53567 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CEBPG | Homo sapiens | P53567 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | CEBPG | Homo sapiens | P53567 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | TADA2A | Homo sapiens | O75478 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | TADA2A | Homo sapiens | O75478 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | DDIT3 | Homo sapiens | P35638 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | DDIT3 | Homo sapiens | P35638 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | DDIT3 | Homo sapiens | P35638 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | DDIT3 | Homo sapiens | P35638 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | NAA10 | Homo sapiens | P41227 | 36442525 | |
|
Intra
|
NFE2L2 | Q16236 | NAA10 | Homo sapiens | P41227 | 36442525 | |
|
Intra
|
NFE2L2 | Q16236 | WAC | Homo sapiens | Q9BTA9 | 25416956 | |
|
Intra
|
NFE2L2 | Q16236 | KEAP1 | Homo sapiens | Q14145 | 16888629 | |
|
Intra
|
NFE2L2 | Q16236 | KEAP1 | Homo sapiens | Q14145 | 16888629 | |
|
Intra
|
NFE2L2 | Q16236 | JUN | Homo sapiens | P05412 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | LEF1 | Homo sapiens | Q9UJU2 | 32911434 | |
|
Intra
|
NFE2L2 | Q16236 | LEF1 | Homo sapiens | Q9UJU2 | 32911434 |
NFE2L2 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P80471 | Phospho-Nrf2 (Ser40) Antibody (YA168) | WB, ICC/IF, IHC-P, FC, IP | Human |
| HY-P80841 | Phospho-Nrf2 (Ser40) Antibody (YA169) | WB, IHC-P | Human |
| HY-P80841A | Phospho-Nrf2 (Ser40) Antibody (YA169)(PBS only) | WB, IHC-P | Human |
| HY-P81051 | Nrf2 Antibody(YA895) | WB, IHC-P, ICC/IF, IP, ChIP | Human, Mouse |
| HY-P81051A | Nrf2 Antibody(YA895)(PBS only) | WB, IHC-P, ICC/IF, IP, ChIP | Human, Mouse |
| HY-P84609 | Nrf2 Antibody (YA4306) | IHC-P, ELISA | Human |
| HY-P84609A | Nrf2 Antibody (YA4306)(PBS only) | IHC-P, ELISA | Human |
| HY-P85818 | Nrf2 Antibody (YA5510) | WB, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P86092 | Nrf2 Antibody (YA5784) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
| HY-P86664 | Nrf2 Antibody (YA6356) | WB, IHC-P, IHC-F, IF-Tissue, FC, ICC/IF | Human, Mouse, Rat |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Friedreich Ataxia |
|
|
| Ischemia |
|
|
| Hypertension, Essential |
|
|
| Parkinson Disease 17 |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Diabetes Mellitus |
|
|
| Macular Degeneration, Age-Related, 1 |
|
|
| Eye Disease |
|
|
| Paraganglioma |
|
|
| Deficiency Anemia |
|
|
| Malaria |
|
|
| Colorectal Cancer |
|
|
| Acute Tympanitis |
|
|
| Hepatocellular Carcinoma |
|
|
| Hemochromatosis, Type 1 |
|
|
| Diabetic Encephalopathy |
|
|
| Lung Cancer |
|
|
| Renal Cell Carcinoma, Papillary, 1 |
|
|
| Bladder Urothelial Carcinoma |
|
|
| Vagus Nerve Disease |
|
|
| Nervous System Disease |
|
|
| Stroke, Ischemic |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Prostate Cancer |
|
|
| Ureteral Obstruction |
|
|
| Mucositis |
|
|
| Squamous Cell Carcinoma |
|
|
| Cystic Fibrosis |
|
|
| Leiomyomatosis |
|
|
| Non-Alcoholic Fatty Liver Disease |
|
|
| Lung Squamous Cell Carcinoma |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Peripheral Nervous System Disease |
|
|
| Pneumothorax |
|
|
| Vascular Disease |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Cervical Cancer |
|
|
| Cataract |
|
|
| Toxic Encephalopathy |
|
|
| Asthma |
|
|
| Pheochromocytoma |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Immunodeficiency, Developmental Delay, And Hypohomocysteinemia |
|
|
| Retinitis Pigmentosa |
|
|
| Osteoporosis |
|
|
| Neuroblastoma |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Rattus norvegicus | NFE2L2 | RGD | RGD:620360 |
| Mus musculus | NFE2L2 | MGD | MGI:108420 |
| Felis catus | NFE2L2 | VGNC | VGNC:68475 |
| Canis familiaris | NFE2L2 | VGNC | VGNC:43773 |
| Bos taurus | NFE2L2 | VGNC | VGNC:32036 |
| Macaca mulatta | NFE2L2 | VGNC | VGNC:75332 |
| Others | NFE2L2 | NCBI |