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製品番号: HY-N21965

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Thesinine

Thesinine is a saturated pyrrolizidine alkaloid and the primary alkaloid found in the seeds and flowers of Borago officinalis. Thesinine binds to AKT1, MAPK3, MMP9, and MAPK14 proteins as predicted by in silico analysis. Thesinine is applicable to research related to skin aging

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 488-02-8
分子式: C₁₇H₂₁NO₃
分子量:287.35

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Thesinine 構造式

CAS 番号: 488-02-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

Akt1

MMP9

MAPK3

MAPK14

Akt アイソフォーム固有の製品をすべて表示 :

MMP アイソフォーム固有の製品をすべて表示 :

体外実験

Thesinine forms energetically favorable interactions with human AKT1 (allosteric site), MAPK3, MMP9, and MAPK14 proteins, among which it exhibits the highest binding affinity for AKT1 (allosteric site)^[1].
Thesinine forms stable and persistent interactions with human AKT1 (allosteric site) and MMP9 proteins during 100 ns molecular dynamics simulations, but its binding stability with human MAPK14 is reduced^[1].
Thesinine is the sole alkaloid in the flowers of borage (Borago officinalis) and also the major alkaloid in mature seeds^[2].
Thesinine is the only detected alkaloid in a batch of immature seeds, while it is not detected in any of the three seed oil samples^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

化学情報

CAS 番号 488-02-8
分子量 287.35
分子式 C₁₇H₂₁NO₃
SMILES

OC(C=C1)=CC=C1/C=C/C(OC[C@H]2[C@]3([H])N(CCC3)CC2)=O
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Cho MH, et al. An Integrated Systems Pharmacology Approach Combining Bioinformatics, Untargeted Metabolomics and Molecular Dynamics to Unveil the Anti-Aging Mechanisms of Tephroseris flammea. Biomolecules. 2025 Dec 15;15(12):1740. [Content Brief]

[2]. Dodson C D, et al. Pyrrolizidine alkaloids from borage (Borago officinalis) seeds and flowers[J]. Journal of Natural products, 1986, 49(4): 727-728.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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Thesinine

Akt アイソフォーム固有の製品をすべて表示

MMP アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Thesinine 関連分類

HY-N21965 関連分類

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Keywords

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