Dimetridazole
Based on 1 publication(s) in Google Scholar
Dimetridazole is a nitroimidazole antibiotic. Dimetridazole inhibits protein synthesis in cultures of Campylobacter jejuni. Dimetridazole is genotoxic. Dimetridazole can be used in the research of protozoal and bacterial infections.
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- Purity: 98.0%
- CAS No.: 551-92-8
- 화학식: C5H7N3O2
- 분자량:141.13
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Dimetridazole
MoreAll Parasite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| THP-1 | IC50 |
>1771 μM
Compound: 4
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Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide-based flow cytometry
Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide-based flow cytometry
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[PMID: 18590939] |
Dimetridazole (50 μg/mL; 2-3 h) blocks protein synthesis in Campylobacter jejuni cultures[2].
Dimetridazole shows activity against 16 clinical isolates of Bacteroides fragilis with a geometric mean MIC of 6.39 μM[3].
Dimetridazole (70-354.3 μM; 1 h) induces dose-dependent DNA damage in human lymphocytes under aerobic conditions[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 551-92-8
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Appearance Solid
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분자량 141.13
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화학식 C5H7N3O2
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Color White to off-white
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SMILES
O=[N+](C1=CN=C(C)N1C)[O-]
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Synonyms
1,2-Dimethyl-5-nitroimidazole
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
용액&용해도
DMSO : 50 mg/mL (354.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (17.71 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (17.71 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (276 KB)
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Handling Instructions (2659 KB)
References
[1]. Zaghdoudi M, et al. Direct and indirect electrochemical reduction prior to a biological treatment for dimetridazoleremoval. J Hazard Mater. 2017 Aug 5;335:10-17. [Content Brief]
[2]. Fernie DS, et al. The effect of the nitroimidazole drug dimetridazole on microaerophilic campylobacters. J Med Microbiol. 1977 May;10(2):233-40. [Content Brief]
[3]. Jokipii L, et al. Comparative evaluation of the 2-methyl-5-nitroimidazole compounds dimetridazole, metronidazole, secnidazole, ornidazole, tinidazole, carnidazole, and panidazole against Bacteroides fragilis and other bacteria of the Bacteroides fragilis group. Antimicrob Agents Chemother. 1985 Oct;28(4):561-4. [Content Brief]
[4]. Ré JL, et al. Evaluation of the genotoxic activity of metronidazole and dimetridazole in human lymphocytes by the comet assay. Mutat Res. 1997 Apr 29;375(2):147-55. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.0857 mL | 35.4283 mL | 70.8567 mL | 177.1416 mL |
| 5 mM | 1.4171 mL | 7.0857 mL | 14.1713 mL | 35.4283 mL | |
| 10 mM | 0.7086 mL | 3.5428 mL | 7.0857 mL | 17.7142 mL | |
| 15 mM | 0.4724 mL | 2.3619 mL | 4.7238 mL | 11.8094 mL | |
| 20 mM | 0.3543 mL | 1.7714 mL | 3.5428 mL | 8.8571 mL | |
| 25 mM | 0.2834 mL | 1.4171 mL | 2.8343 mL | 7.0857 mL | |
| 30 mM | 0.2362 mL | 1.1809 mL | 2.3619 mL | 5.9047 mL | |
| 40 mM | 0.1771 mL | 0.8857 mL | 1.7714 mL | 4.4285 mL | |
| 50 mM | 0.1417 mL | 0.7086 mL | 1.4171 mL | 3.5428 mL | |
| 60 mM | 0.1181 mL | 0.5905 mL | 1.1809 mL | 2.9524 mL | |
| 80 mM | 0.0886 mL | 0.4429 mL | 0.8857 mL | 2.2143 mL | |
| 100 mM | 0.0709 mL | 0.3543 mL | 0.7086 mL | 1.7714 mL |
Dimetridazole Related Classifications
HY-B1244 Related Classifications
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