MDM2 - MDM2 proto-oncogene Gene

Also Known as HDMX; LSKB; hdm2; ACTFS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4193

About MDM2

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:68,808,172-68,850,686 (from NCBI)

This gene has 36 transcripts (splice variants), 253 orthologues, 1 paralogue and is associated with 79 phenotypes. Ubiquitous expression in colon (RPKM 13.6), bone marrow (RPKM 9.8) and 25 other tissues.

Summary

This gene encodes a nuclear-localized E3 ubiquitin Ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

MDM2 Products (14)

mRNA	Protein	Name
NM_006878.3
NM_001145340.3	NP_001138812.1	E3 ubiquitin-protein ligase Mdm2 isoform i
NM_006882.3
NM_001278462.2	NP_001265391.1	E3 ubiquitin-protein ligase Mdm2 isoform l
NM_001367990.1	NP_001354919.1	E3 ubiquitin-protein ligase Mdm2 isoform 2
NM_001145339.2	NP_001138811.1	E3 ubiquitin-protein ligase Mdm2 isoform h
XM_047428853.1	XP_047284809.1	E3 ubiquitin-protein ligase Mdm2 isoform X1
NM_002392.6	NP_002383.2	E3 ubiquitin-protein ligase Mdm2 isoform a
NM_006880.2
NM_001145336.1
NM_032739.1
NM_001145337.3	NP_001138809.1	E3 ubiquitin-protein ligase Mdm2 isoform g
NM_006879.3
NM_006881.3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 5S rRNA binding	IDA IDA: Inferred from direct assay	24120868	GOA
enables NEDD8 ligase activity	IMP IMP: Inferred from mutant phenotype	18560357	GOA
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	21900752	GOA
enables disordered domain specific binding	IPI IPI: Inferred from physical interaction	12630860	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	15577914	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17159902	GOA
enables ligase activity	IDA IDA: Inferred from direct assay	17142452	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	9529249	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7791904	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	16479015	GOA
enables ribonucleoprotein complex binding	IDA IDA: Inferred from direct assay	24120868	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	29295817	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	15314173	GOA
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	16479015	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	18382127	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	9450543	GOA
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	20173098	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	10722742	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP IMP: Inferred from mutant phenotype	21726810	GOA
involved in amyloid fibril formation	IMP IMP: Inferred from mutant phenotype	12630860	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	30879903	GOA
involved in cellular response to actinomycin D	IDA IDA: Inferred from direct assay	15314173	GOA
involved in cellular response to gamma radiation	IDA IDA: Inferred from direct assay	16213212	GOA
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	20810912	GOA
involved in establishment of protein localization	IDA IDA: Inferred from direct assay	10360174	GOA
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	9529249	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9271120	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16479015	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17310983	GOA
involved in negative regulation of signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	16173922	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9271120	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	17290220	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	11278372	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	29681526	GOA
involved in protein autoubiquitination	IMP IMP: Inferred from mutant phenotype	16479015	GOA
involved in protein destabilization	IDA IDA: Inferred from direct assay	9529249	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	16479015	GOA
involved in protein localization to nucleus	IDA IDA: Inferred from direct assay	10360174	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	9450543	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	10608892	GOA
involved in proteolysis involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	25417702	GOA
acts upstream of regulation of cell cycle	IDA IDA: Inferred from direct assay	9529249	GOA
involved in regulation of protein catabolic process	IDA IDA: Inferred from direct assay	9153395	GOA
involved in response to antibiotic	IEP IEP: Inferred from expression pattern	20810912	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	11278372	GOA
involved in ubiquitin-dependent protein catabolic process	IGI IGI: Inferred from genetic interaction	17237821	GOA
acts upstream of or within ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	24506068	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	16479015	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	30879903	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	15314173	GOA
colocalizes with nuclear body	IDA IDA: Inferred from direct assay	10360174	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	10707090	GOA
located in nucleolus	IMP IMP: Inferred from mutant phenotype	11718560	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	10707090	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10360174	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	15314173	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	9529249	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	11718560	GOA
part of transcription repressor complex	IPI IPI: Inferred from physical interaction	8875929	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MDM2 Protein Structure

SWIB

zf-RanBP

zf-C3HC4_3

0
100
200
300
400
497 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase Mdm2	MDM2 oncogene, E3 ubiquitin protein ligase MDM2 proto-oncogene, E3 ubiquitin protein ligase Mdm2, p53 E3 ubiquitin protein ligase homolog Mdm2, transformed 3T3 cell double minute 2, p53 binding protein double minute 2, human homolog of p53-binding protein oncoprotein Mdm2

MDM2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MDM2	Q00987	FKBP3	Homo sapiens	Q00688	Anti Bait CoIP	19166840
Intra	MDM2	Q00987	SET	Homo sapiens	Q01105	Display Tech	20195357
Intra	MDM2	Q00987	OTUB1	Homo sapiens	Q96FW1	Pull Down	22124327
Intra	MDM2	Q00987	RYR2	Homo sapiens	Q92736	Display Tech	20195357
Intra	MDM2	Q00987	CSNK1A1	Homo sapiens	P48729	Anti Tag CoIP	20708156
Intra	MDM2	Q00987	PPM1D	Homo sapiens	O15297	Anti Bait CoIP	17936559
Intra	MDM2	Q00987	CSNK1A1	Homo sapiens	P48729-2	Pull Down	20708156
Intra	MDM2	Q00987	RNF115	Homo sapiens	Q9Y4L5	Phage Display	35044719
Intra	MDM2	Q00987	RNF115	Homo sapiens	Q9Y4L5	FPS	35044719
Cross	MDM2	Q00987	P0C6X5-PRO_0000283876	Human coronavirus NL63	P0C6X5-PRO_0000283876	Anti Tag CoIP	25505178
Cross	MDM2	Q00987	P0C6X5-PRO_0000283876	Human coronavirus NL63	P0C6X5-PRO_0000283876	Confocal	25505178
Intra	MDM2	Q00987	JUND	Homo sapiens	P17535	Display Tech	20195357
Intra	MDM2	Q00987	JUND	Homo sapiens	P17535	TAP	20195357
Intra	MDM2	Q00987	PML	Homo sapiens	P29590	Anti Bait CoIP	12915590
Intra	MDM2	Q00987	PML	Homo sapiens	P29590	CoIP	12915590
Intra	MDM2	Q00987	PML	Homo sapiens	P29590	Imaging	12915590
Intra	MDM2	Q00987	AKT1	Homo sapiens	P31749	Experimental Interac	15527798
Intra	MDM2	Q00987	AKT1	Homo sapiens	P31749	PLA	25241761
Intra	MDM2	Q00987	USP7	Homo sapiens	Q93009	FPS	34799561
Intra	MDM2	Q00987	USP7	Homo sapiens	Q93009	Anti Bait CoIP	18566590
Intra	MDM2	Q00987	USP7	Homo sapiens	Q93009	Anti Bait CoIP	17936559
Intra	MDM2	Q00987	USP7	Homo sapiens	Q93009	Anti Tag CoIP	16845383
Intra	MDM2	Q00987	PML	Homo sapiens	P29590-5	Imaging	12915590
Intra	MDM2	Q00987	PML	Homo sapiens	P29590-5	Anti Bait CoIP	12915590
Intra	MDM2	Q00987	PML	Homo sapiens	P29590-5	CoIP	12915590
Intra	MDM2	Q00987	HNRNPK	Homo sapiens	P61978	Anti Bait CoIP	23092970
Intra	MDM2	Q00987	BTRC	Homo sapiens	Q9Y297	Anti Bait CoIP	20708156
Intra	MDM2	Q00987	BTRC	Homo sapiens	Q9Y297	Anti Tag CoIP	20708156
Intra	MDM2	Q00987	BTRC	Homo sapiens	Q9Y297	Pull Down	20708156
Intra	MDM2	Q00987	UBC	Homo sapiens	P0CG48	Pull Down	17290220
Intra	MDM2	Q00987	NCL	Homo sapiens	P19338	Far-WB	22103682
Intra	MDM2	Q00987	NCL	Homo sapiens	P19338	Pull Down	22103682
Intra	MDM2	Q00987	RPS3	Homo sapiens	P23396	PLA	19656744
Intra	MDM2	Q00987	RPS3	Homo sapiens	P23396	Ubiquitinase Assay	19656744
Intra	MDM2	Q00987	RPS3	Homo sapiens	P23396	Pull Down	19656744
Intra	MDM2	Q00987	EEF1A1	Homo sapiens	P68104	Pull Down	23260144
Intra	MDM2	Q00987	EEF1A1	Homo sapiens	P68104	Anti Bait CoIP	17373842
Intra	MDM2	Q00987	EEF1A1	Homo sapiens	P68104	Confocal	17373842
Intra	MDM2	Q00987	S100A6	Homo sapiens	P06703	GMS	20591429
Intra	MDM2	Q00987	RPL23	Homo sapiens	P62829	Anti Bait CoIP	17110929
Intra	MDM2	Q00987	RPS7	Homo sapiens	P62081	Y2H	17310983
Intra	MDM2	Q00987	RPS7	Homo sapiens	P62081	Anti Tag CoIP	17310983
Intra	MDM2	Q00987	RPS7	Homo sapiens	P62081	Pull Down	17310983
Intra	MDM2	Q00987	RPS7	Homo sapiens	P62081	Y2H	21988832
Intra	MDM2	Q00987	RPS7	Homo sapiens	P62081	Anti Bait CoIP	17310983
Intra	MDM2	Q00987	RPL11	Homo sapiens	P62913	Anti Bait CoIP	17110929
Intra	MDM2	Q00987	RPL11	Homo sapiens	P62913	Anti Bait CoIP	21399665
Intra	MDM2	Q00987	RPL11	Homo sapiens	P62913	Y2H	21988832
Intra	MDM2	Q00987	RPL11	Homo sapiens	P62913	Anti Bait CoIP	17373842
Intra	MDM2	Q00987	RPL11	Homo sapiens	P62913	Anti Tag CoIP	19713960
Intra	MDM2	Q00987	RPS27L	Homo sapiens	Q71UM5	Anti Tag CoIP	21170087
Intra	MDM2	Q00987	RPS27L	Homo sapiens	Q71UM5	Anti Bait CoIP	21170087
Intra	MDM2	Q00987	PSME3	Homo sapiens	P61289	Anti Tag CoIP	18309296
Intra	MDM2	Q00987	PSME3	Homo sapiens	P61289	Pull Down	18309296
Intra	MDM2	Q00987	PSME3	Homo sapiens	P61289	Anti Bait CoIP	18309296
Intra	MDM2	Q00987	PSME3	Homo sapiens	P61289	GMS	18309296
Intra	MDM2	Q00987	RPS27	Homo sapiens	P42677	Anti Tag CoIP	21170087
Intra	MDM2	Q00987	RPS27	Homo sapiens	P42677	Pull Down	21170087
Intra	MDM2	Q00987	RPS27	Homo sapiens	P42677	Anti Bait CoIP	21170087
Intra	MDM2	Q00987	RPL5	Homo sapiens	P46777	Anti Bait CoIP	21399665
Intra	MDM2	Q00987	RPL5	Homo sapiens	P46777	Anti Bait CoIP	17373842
Intra	MDM2	Q00987	RPL5	Homo sapiens	P46777	Anti Bait CoIP	17110929
Intra	MDM2	Q00987	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	20708156
Intra	MDM2	Q00987	CUL1	Homo sapiens	Q13616	Anti Bait CoIP	20708156
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Anti Bait CoIP	15848166
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Pull Down	18485870
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Anti Bait CoIP	17310983
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	ELISA	17875722
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Anti Bait CoIP	16845383
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Fluorescence Spectr	16432196
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Anti Tag CoIP	19098711
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	NMR	16432196
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	GMS	18309296
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Anti Bait CoIP	18309296
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Anti Bait CoIP	12915590
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Pull Down	17875722
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Pull Down	17139261
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Solution Sedimentation	16432196
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Anti Bait CoIP	17268548
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Anti Bait CoIP	15144954
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Pull Down	18309296
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Pull Down	10196247
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	ITC	16432196
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	SPR	14704432
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Peptide Array	16432196
Intra	MDM2	Q00987	TP53	Homo sapiens	P04637	Anti Bait CoIP	18172499
Intra	MDM2	Q00987	RASSF1	Homo sapiens	Q9NS23	Anti Bait CoIP	18566590
Intra	MDM2	Q00987	GRK2	Homo sapiens	P25098	Anti Bait CoIP	17006543
Intra	MDM2	Q00987	NR0B2	Homo sapiens	Q15466	Anti Bait CoIP	22575647
Intra	MDM2	Q00987	NR0B2	Homo sapiens	Q15466	Anti Tag CoIP	22575647
Intra	MDM2	Q00987	GORAB	Homo sapiens	Q5T7V8	Anti Tag CoIP	20598683
Intra	MDM2	Q00987	MDM4	Homo sapiens	O15151	Anti Tag CoIP	15604276
Intra	MDM2	Q00987	MDM4	Homo sapiens	O15151	CoIP	10608892
Intra	MDM2	Q00987	MDM4	Homo sapiens	O15151	Pull Down	22902369
Intra	MDM2	Q00987	MDM4	Homo sapiens	O15151	Anti Bait CoIP	18566590
Intra	MDM2	Q00987	MDM4	Homo sapiens	O15151	Y2H	10608892
Intra	MDM2	Q00987	PLK1	Homo sapiens	P53350	Anti Bait CoIP	19833129
Intra	MDM2	Q00987	PLK1	Homo sapiens	P53350	Protein Kinase Assay	19833129
Intra	MDM2	Q00987	RB1	Homo sapiens	P06400	Anti Bait CoIP	20871633
Intra	MDM2	Q00987	RB1	Homo sapiens	P06400	Pull Down	16374512
Intra	MDM2	Q00987	CASP3	Homo sapiens	P42574	Protease Assay	21726810
Intra	MDM2	Q00987	AR	Homo sapiens	P10275	Anti Bait CoIP	18332867
Intra	MDM2	Q00987	CDKN2A	Homo sapiens	Q8N726	Anti Bait CoIP	17909018
Intra	MDM2	Q00987	CDKN2A	Homo sapiens	Q8N726	CoIP	19166854
Intra	MDM2	Q00987	CDKN2A	Homo sapiens	Q8N726	IF	12740913
Intra	MDM2	Q00987	CDKN2A	Homo sapiens	Q8N726	Anti Bait CoIP	18583933
Cross	MDM2	Q00987	Npm1	Mus musculus	Q61937	Anti Bait CoIP	15144954
Intra	MDM2	Q00987	GNL3	Homo sapiens	Q9BVP2	Anti Tag CoIP	21132010
Intra	MDM2	Q00987	ARRB1	Homo sapiens	P49407	Anti Tag CoIP	19879840
Intra	MDM2	Q00987	S100A1	Homo sapiens	P23297	GMS	20591429
Intra	MDM2	Q00987	GNL3L	Homo sapiens	Q9NVN8	Anti Tag CoIP	21132010
Intra	MDM2	Q00987	CSNK1E	Homo sapiens	P49674	Anti Tag CoIP	20708156
Intra	MDM2	Q00987	CSNK1D	Homo sapiens	P48730	Anti Tag CoIP	20708156
Intra	MDM2	Q00987	CSNK1D	Homo sapiens	P48730	IF	20708156
Intra	MDM2	Q00987	S100A2	Homo sapiens	P29034	GMS	20591429
Intra	MDM2	Q00987	RYBP	Homo sapiens	Q8N488	Anti Bait CoIP	19098711
Intra	MDM2	Q00987	RYBP	Homo sapiens	Q8N488	Y2H	19098711
Intra	MDM2	Q00987	RYBP	Homo sapiens	Q8N488	Anti Tag CoIP	19098711
Intra	MDM2	Q00987	RYBP	Homo sapiens	Q8N488	Pull Down	19098711
Intra	MDM2	Q00987	DAXX	Homo sapiens	Q9UER7	Anti Tag CoIP	16845383
Intra	MDM2	Q00987	DAXX	Homo sapiens	Q9UER7	Anti Bait CoIP	18566590
Intra	MDM2	Q00987	DAXX	Homo sapiens	Q9UER7	IF	15364927
Intra	MDM2	Q00987	DAXX	Homo sapiens	Q9UER7	Anti Tag CoIP	18566590
Intra	MDM2	Q00987	DAXX	Homo sapiens	Q9UER7	Anti Bait CoIP	16845383
Intra	MDM2	Q00987	ESR1	Homo sapiens	P03372	Y2H	11178989
Intra	MDM2	Q00987	ESR1	Homo sapiens	P03372	Pull Down	11178989
Intra	MDM2	Q00987	NPM1	Homo sapiens	P06748	Anti Bait CoIP	22510990
Intra	MDM2	Q00987	DLG4	Homo sapiens	P78352	Pull Down	23260144
Cross	MDM2	Q00987	Fkbp3	Mus musculus	Q62446	Pull Down	19166840
Intra	MDM2	Q00987	JUN	Homo sapiens	P05412	Display Tech	20195357
Intra	MDM2	Q00987	JMY	Homo sapiens	Q8N9B5	Anti Bait CoIP	17170761
Intra	MDM2	Q00987	KIAA1671	Homo sapiens	Q9BY89	Phage Display	35044719
Intra	MDM2	Q00987	RRM2B	Homo sapiens	Q7LG56	Anti Bait CoIP	19015526
Intra	MDM2	Q00987	NUMB	Homo sapiens	P49757	Anti Bait CoIP	18172499
Intra	MDM2	Q00987	NUMB	Homo sapiens	P49757	FPS	35044719
Cross	MDM2	Q00987	Arrb2	Rattus norvegicus	P29067	FRET	17984062
Cross	MDM2	Q00987	Arrb2	Rattus norvegicus	P29067	BRET	17984062

Cross: Cross-species interaction Intra: Intraspecies interaction

MDM2 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P82143	Phospho-MDM2 (Ser166) Antibody (YA1888)	WB, IHC-P	Human, Rat
HY-P82143A	Phospho-MDM2 (Ser166) Antibody (YA1888)(PBS only)	WB, IHC-P	Human, Rat
HY-P83705	MDM2 Antibody (YA3442)	WB, IHC-P, ICC/IF	Human, Monkey
HY-P84453	MDM2 Antibody (YA4150)	IHC-P, FC, ELISA	Human
HY-P84453A	MDM2 Antibody (YA4150)(PBS only)	IHC-P, FC, ELISA	Human
HY-P86219	MDM2 Antibody (YA5911)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Malignant Fibrous Histiocytoma	Undifferentiated Pleomorphic Sarcoma Ups Fibroxanthosarcoma Mfh Malignant Fibrohistiocytic Tumors Histiocytoma, Malignant Fibrous Histiocytoma, Fibrous, Malignant
Heart Cancer	Malignant Neoplasm Of Heart Heart Neoplasm Cardiac Tumor Malignant Cardiac Tumor Tumour Of Heart Heart Neoplasms Cardiac Carcinoma
Adult Liposarcoma
Embryonal Rhabdomyosarcoma	Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma Embryonal Botryoid Rhabdomyosarcoma Erms Spindle Cell Rhabdomyosarcomas
Synovium Cancer	Malignant Tumor Of Synovium Synovial Neoplasm
Liposarcoma	Lipomatous Cancer
Lipoma Of Spermatic Cord	Spermatic Cord Lipoma
Oligodendroglioma	Oligodendroglial Neoplasm Oligodendroglial Tumor Oligodendroglial Tumors Well Differentiated Oligodendroglioma
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Chondroid Lipoma
Ischemic Fasciitis	Atypical Decubital Fibroplasia
Retinal Cancer	Malignant Neoplasm Of Retina Retinal Neoplasms Malignant Retinal Neoplasm Malignant Tumor Of Retina Neoplasm Of Retina Retinal Tumor Retinal Neoplasm Cancer Of The Retina Malignant Retinal Tumour Malignant Tumour Of Retina Primary Malignant Neoplasm Of Retina
Benign Meningioma	Meningioma, Benign
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Accelerated Tumor Formation	Accelerated Tumor Formation, Susceptibility To ACTFS Tumor Formation, Accelerated, Susceptibility To
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Cellular Myxoid Liposarcoma	Round Cell Liposarcoma
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 CMM1 Melanoma, Cutaneous Malignant Cmm Melanoma, Malignant Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Lessel-Kubisch Syndrome	LSKB
Aortic Malignant Tumor	Aortic Malignant Neoplasm Malignant Aortic Neoplasm
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Lipomatosis, Multiple	Lipoma Familial Multiple Lipomatosis Lipomatosis, Familial Multiple Benign Lipomatous Tumor Lipomatous Neoplasm Multiple Lipomatosis Fml Lipo Benign Tumor Of Adipose Tissue Lipomatous Tumor Tumor Of Adipose Tissue Neoplasms, Adipose Tissue Lipomas
Spindle Cell Liposarcoma
Esophageal Lipoma	Lipoma Of Esophagus
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Heart Sarcoma	Cardiac Sarcoma Sarcoma Of Heart
Progeroid Syndrome
Infiltrating Angiolipoma	Angiolipoma, Infiltrating
Glioblastoma Classical Subtype
Cheilitis
Retroperitoneal Sarcoma
Infiltrating Lipoma	Intramuscular Lipoma
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Brain Cancer	Malignant Neoplasm Of Brain Adult Brain Tumor Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Pleomorphic Liposarcoma	Pls Liposarcoma Pleomorphic Liposarcoma, Pleomorphic
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Spindle Cell Sarcoma	Sarcoma Sarcoma Spindle Cell Sarcoma, Spindle Cell Sarcoma - Category
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Leiomyosarcoma	Leiomyosarcomas
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Fibrosarcomatous Osteosarcoma	Fibroblastic Osteosarcoma Fibrosarcomatous Osteogenic Sarcoma
Gastric Liposarcoma	Liposarcoma Of The Stomach
Autonomic Nervous System Neoplasm	Tumor Of Autonomic Nervous System
Well-Differentiated Liposarcoma	Atypical Lipomatous Tumor Atypical Lipoma Alt Wdls Liposarcoma, Well Differentiated Pleomorphic Lipoma
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Esophagus Verrucous Carcinoma	Oesophagus Verrucous Carcinoma Verrucous Carcinoma Of Esophagus Verrucous Carcinoma Of Oesophagus Verrucous Carcinoma Of The Esophagus
Periosteal Osteogenic Sarcoma	Periosteal Osteosarcoma Parosteal Osteosarcoma
Maxillary Sinus Adenocarcinoma	Adenocarcinoma Of Maxillary Sinus Adenocarcinoma Of The Maxillary Sinus
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Malignant Pleural Mesothelioma	Malignant Mesothelioma Of Pleura Pleural Malignant Mesothelioma
Advanced Sleep Phase Syndrome, Familial, 1	Advanced Sleep Phase Syndrome 1 FASPS1 Familial Advanced Sleep Phase Syndrome 1 Sleep Phase Syndrome, Advanced, Familial, Type 1
Telangiectatic Osteogenic Sarcoma	Telangiectatic Osteosarcoma
Bone Sarcoma
Skeletal Muscle Cancer	Malignant Tumor Of Skeletal Muscle Skeletal Muscle Neoplasm
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Conventional Osteosarcoma	Intracortical Osteosarcoma Conventional Central Osteosarcoma Intracortical Osteogenic Sarcoma Medullary Osteosarcoma
Colon Leiomyosarcoma	Colonic Leiomyosarcoma
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Mixed Liposarcoma	Mixed-Type Liposarcoma Myxoid/Round Cell Liposarcoma
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Thymus Lipoma	Thymolipoma
Heart Leiomyosarcoma	Leiomyosarcoma Of Heart Cardiac Leiomyosarcoma
Inflammatory Liposarcoma
Extraosseous Osteosarcoma	Extraskeletal Osteosarcoma Extraskeletal Osteogenic Sarcoma
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Diffuse Lipomatosis
Chondrosarcoma	Cartilaginous Cancer Chondrosarcoma Of Bone Primary Chondrosarcoma Of The Bone CHDSA
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Immune System Organ Benign Neoplasm
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Spindle Cell Lipoma
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Connective Tissue Benign Neoplasm	Soft Tissue Neoplasms Mesenchymal Tissue Neoplasm Neoplasm Of Soft Tissue Neoplasm Of Soft Tissues Soft Tissue Benign Neoplasm Tumor Of The Soft Tissue Soft Tissue Neoplasm
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Conventional Lipoma	Classic Type Lipoma
Paratesticular Lipoma
Peripheral Nervous System Neoplasm	Nerve Sheath Neoplasm Peripheral Nervous System Neoplasms Neoplasm Of Peripheral Nerve Tumor Of Pns Nerve Sheath Neoplasms Nerve Sheath Tumors
Mediastinal Mesenchymal Tumor	Mediastinal Mesenchymal Tumour Soft Tissue Tumor Of Mediastinum Soft Tissue Tumour Of Mediastinum
Chordoma	CHDM Notochordoma Notochordal Sarcoma Chordoma, Susceptibility To Chordocarcinoma Chordoepithelioma
Anaplastic Ependymoma	Ependymoma, Anaplastic Undifferentiated Ependymoma
Childhood Liposarcoma	Pediatric Liposarcoma
Childhood Acute Lymphocytic Leukemia	Childhood Acute Lymphoblastic Leukemia Childhood All Pediatric Acute Lymphoblastic Leukemia Lymphoblastic Leukemia Acute Childhood
Lipoma Of Colon	Colonic Lipoma Colon Lipoma
Parosteal Osteosarcoma	Juxtacortical Osteosarcoma Parosteal Osteogenic Sarcoma Osteosarcoma, Juxtacortical
Peripheral Osteosarcoma	Surface Osteosarcoma Bone Surface Osteosarcoma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Pancreas Sarcoma	Sarcoma Of Pancreas
Sclerosing Liposarcoma
Pleomorphic Adenoma	Mixed Tumor Of The Salivary Gland Adenoma Pleomorphic Adenoma, Pleomorphic Mixed Salivary Gland Tumor Mixed Tumor, Not Otherwise Specified
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Rhabdomyosarcoma
Large Intestine Lipoma	Lipoma Of Large Intestine Colorectal Lipoma
Spermatic Cord Cancer	Malignant Tumor Of Spermatic Cord Malignant Tumor Of The Spermatic Cord Spermatic Cord Ca Malignant Neoplasm Of Spermatic Cord
Chest Wall Lipoma	Lipoma Of The Chest Wall Lipoma Of Chest Wall
Pancreatic Adenocarcinoma	Adenocarcinoma Of Pancreas Adenocarcinoma Of The Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Familial Retinoblastoma	Hereditary Retinoblastoma Retinoblastoma
Giant Cell Glioblastoma	Monstrocellular Sarcoma
Malignant Peripheral Nerve Sheath Tumor	Mpnst Malignant Neurilemmoma Neurofibrosarcoma Malignant Neurofibroma Malignant Schwannoma Neurogenic Sarcoma Malignant Neoplasm Of The Peripheral Nerve Sheath Schwannoma, Malignant Malignant Peripheral Nerve Sheath Tumors
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Pleomorphic Lipoma	Lipoma Lipoma Pleomorphic Lipomatosis, Multiple
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Myositis Ossificans	Myisitis Ossificans Ossification - Muscle
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Kidney Liposarcoma	Liposarcoma Of Kidney
Breast Liposarcoma	Liposarcoma Of The Breast
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Glioma
Malignant Inflammatory Fibrous Histiocytoma	Inflammatory Mfh Xanthosarcoma
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Liposarcoma Of Bone	Liposarcoma Of The Bone
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Anaplastic Oligodendroglioma
Angiolipoma
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Mediastinum Liposarcoma	Liposarcoma Of Mediastinum
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma Primitive Neuroectodermal Tumor ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Ewing Family Of Tumors Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Uterine Sarcoma	Sarcoma Of The Uterus Uterine Corpus Sarcoma
Hemangiopericytoma, Malignant	Hemangiopericytoma Haemangiopericytic Meningioma Malignant Hemangiopericytoma Solitary Fibrous Tumor
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Hepatoblastoma
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Anaplastic Astrocytoma	Grade Iii Astrocytoma Grade Iii Astrocytic Tumor Astrocytoma, Anaplastic
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Retroperitoneal Fibrosis	Idiopathic Retroperitoneal Fibrosis Ormond Disease Igg4-Related Retroperitoneal Fibrosis Ormond'S Disease Rpf - [Retroperitoneal Fibrosis]
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Desmoid Tumor	Aggressive Fibromatosis Desmoid Type Fibromatosis Familial Infiltrative Fibromatosis Desmoid Disorder, Hereditary Fif Fibromatosis, Familial Infiltrative Deep Fibromatosis Desmoid Fibromatosis Hereditary Desmoid Disease Musculoaponeurotic Fibromatosis Desmoid-Type Fibromatosis Fibromatosis, Aggressive Desmoid Disease, Hereditary Musculo-Aponeurotic Fibromatosis
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Ocular Cancer	Eye Carcinoma Eye Neoplasm Eye Cancer Eye Neoplasms Malignant Eye Neoplasm Neoplasm Of Eye Neoplasm Of Eye Proper Ocular Tumor Carcinoma Of Eye Ocular Carcinoma Malignant Tumor Of Eye
Angiosarcoma	Hemangiosarcoma
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Pleomorphic Rhabdomyosarcoma	Adult Pleomorphic Rhabdomyosarcoma Anaplastic Rhabdomyosarcoma Pleomorphic Rhabdomyosarcoma, Adult Type
Malignant Mesenchymoma	Malignant Mesenchymal Tumor Mesenchymoma, Malignant Sarcoma Rat Malignant Renal Mesenchymal Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Phase
HY-N0004	Oridonin		99.89%	Phase 4

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-130684	MDM2 ligand 5		98.02%	Unkown
HY-128837	Nutlin carboxylic acid		98.63%	Unkown
HY-P5930	HOXB7 8–25		/	Unkown
HY-128837A	(rel)-Nutlin carboxylic acid		/	Unkown
HY-128836	(4R,5S)-Nutlin carboxylic acid		/	Unkown
HY-168280	AS1411-C4-VH032	Degrader	/	Unkown
HY-148106	MEL23	Inhibitor	/	Unkown
HY-181813	PROTAC DHFR Degrader-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MDM2	VGNC	VGNC:68223
Mus musculus	MDM2	MGD	MGI:96952
Macaca mulatta	MDM2	VGNC	VGNC:74692
Rattus norvegicus	MDM2	RGD	RGD:1305332
Canis familiaris	MDM2	VGNC	VGNC:43106
Bos taurus	MDM2	VGNC	VGNC:31336
Others	MDM2	NCBI