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GsMTx4 TFA

126 Cited Publications
고객리뷰

Based on 126 publication(s) in Google Scholar

GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.

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  • Purity: 99.85%
  • 화학식: C185H273N49O45S6.xC2HF3O2
  • 분자량:4095.84 (free base)
  • 보관:

    Sealed storage, away from moisture and light.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • GsMTx4 TFA Chemical Structure
    GsMTx4 TFA Chemical Structure
  • Experimental Validation Results for GsMTx4 TFA
  • Experimental Validation Results for GsMTx4 TFA
  • Experimental Validation Results for GsMTx4 TFA
  • Experimental Validation Results for GsMTx4 TFA
  • Experimental Validation Results for GsMTx4 TFA
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주변의 대리점 찾기 Your local distributor: Hycultec GmbHHycultec
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  • GsMTx4 TFA Chemical Structure
    GsMTx4 TFA Chemical Structure
    1/16
  • 1/16

    GsMTx4 TFA purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Aug 21;10(1):269. [Abstract]

    Customer Validation
     Flow cytometry analysis showing that Yoda1-induced Ca²⁺ influx is blocked by GsMTx4（0-1 μM; 120 s）.

  • 1/16

    GsMTx4 TFA purchased from MedChemExpress. Usage Cited in: Nat Biotechnol. 2025 Nov 10. [Abstract]

    Customer Validation
     Administration of GsMTx4 (5 μM; 5 μL) reduced the blood product clearance of UDC, as assessed by hematoma volumes across treatment groups.

  • 1/16

    GsMTx4 TFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Mar 8;16(1):2329. [Abstract]

    Customer Validation
     Phospho-RAB10 (T73) signal measured by western blot in WT Henle 407 cells. The cells were treated with the PIEZO1 inhibitor GsMTx4 (10 μM; 30 min), LPS and/or the PIEZO1 agonist Yoda1, and cell lysates were collected and immunoblotted for phospho-RAB10 (T73), total RAB10, or ß-actin (loading control) .

  • 1/16

    GsMTx4 TFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 25;16(1):6868. [Abstract]

    Customer Validation
     GsMTx4（5 μM; 30 min）- treated BxPC3 DUOX1/2 WT cells, green lines indicate initial wound edges at t = 0 h, red lines indicate wound edges at the indicated timepoints, red arrows show area of damaged cells.

  • 1/16

    GsMTx4 TFA purchased from MedChemExpress. Usage Cited in: Cell. 2024 Jun 20;187(13):3409-3426.e24. [Abstract]

    Customer Validation
     WT CD8⁺ T cells treated with DMSO or a Piezo1 inhibitor (GsMTx4, 5 μM; 2 h).

  • GsMTx4 TFA