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Cat. No.: HY-182605

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NU6310

NU6310 is a non-covalent, ATP-competitive CDK2 inhibitor with an IC₅₀ of 0.16 μM against CDK2. NU6310 can be used for research on cell cycle regulation related to tumors.

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CAS No.: 1453215-59-2
화학식: C₂₀H₂₅N₅O₃S
분자량:415.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NU6310 Chemical Structure

CAS No.: 1453215-59-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
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References
Calculators
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Biological Activity

제품 설명

NU6310 is a non-covalent, ATP-competitive CDK2 inhibitor with an IC₅₀ of 0.16 μM against CDK2. NU6310 can be used for research on cell cycle regulation related to tumors^[1].

IC₅₀ & Target^[1]

CDK2

0.16 μM (IC₅₀)

All CDK Isoforms :

In Vitro

NU6310 is a non-covalent, ATP-competitive inhibitor that inhibits the kinase activity of purified CDK2, with an IC₅₀ of 0.16 μM^[1].
NU6310 (39-10000 nM; 30-240 seconds) binds reversibly to immobilized CDK2/cyclin A, with a K_D of 0.716 μM^[2].
NU6310 (overnight incubation) exerts no covalent modification effect on CDK2/cyclin A; it can be completely removed via dialysis, thereby restoring CDK2's kinase activity for the phosphorylation of the Rb protein^[2].
NU6310 (50 μM; 1 hour) inhibits the phosphorylation of the Rb protein at the Thr821 site in SKUT-1B cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1453215-59-2
분자량 415.51
화학식 C₂₀H₂₅N₅O₃S
SMILES

O=S(C1=CC=C(NC2=NC3=C(C(OCC4CCCCC4)=N2)NC=N3)C=C1)(CC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Tadesse S, et al. Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update. J Med Chem. 2019;62(9):4233-4251. [Content Brief]

[2]. Anscombe E, et al. Identification and characterization of an irreversible inhibitor of CDK2. Bioorganic & Medicinal Chemistry Letters, 2015, 22(9): 1159-1164.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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NU6310

All CDK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

NU6310 Related Classifications

HY-182605 Related Classifications