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Cat. No.: HY-10617AS1

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Rucaparib-d₃

(Synonyms: AG014699-d₃; PF-01367338-d₃)

Rucaparib-d₃ (AG014699-d₃) is the deuterated -labeled Rucaparib (HY-10617A). Rucaparib (AG014699) is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a K_i of 1.4 nM for PARP1. Rucaparib is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib has the potential for castration-resistant prostate cancer (CRPC) research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2271225-13-7
화학식: C₁₉H₁₅D₃FN₃O
분자량:326.38

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Rucaparib-d₃ Chemical Structure

CAS No.: 2271225-13-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
- 신청
Chemical Information
순도&문서
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All PARP Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Animal Model:

Female CD-1 nude mice aged 10-12 weeks with Capan-1 cells^[2]
Dosage:

10 mg/kg for i.p. or 50, 150 mg/kg for p.o.
Administration:

IP or PO
Result:

Significantly inhibited the growth of the tumor.

신청

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 2271225-13-7
Unlabeled Cas 283173-50-2
분자량 326.38
화학식 C₁₉H₁₅D₃FN₃O
SMILES

O=C1C2=C3C(CCN1)=C(C4=CC=C(C=C4)CNC([2H])([2H])[2H])NC3=CC(F)=C2
Synonyms

AG014699-d₃; PF-01367338-d₃
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.