TC-E 5001
TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively.
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- CAS No.: 865565-29-3
- 화학식: C20H19N5O3S
- 분자량:409.46
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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TNKS1 79 nM (Ki) |
TNKS2 28 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.215 μM
Compound: 24
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Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay
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[PMID: 22260203] |
| SW480 | EC50 |
0.709 μM
Compound: 24
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Stabilization of Axin2 in human SW480 cells after 24 hrs by sandwich ELISA
Stabilization of Axin2 in human SW480 cells after 24 hrs by sandwich ELISA
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[PMID: 22260203] |
TC-E 5001 inhibits TNKS2, with an IC50 of 33 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 865565-29-3
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분자량 409.46
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화학식 C20H19N5O3S
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SMILES
CC1=NN=C(SCC2=NC(C3=CC=C(OC)C=C3)=NO2)N1C4=CC=C(OC)C=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TC-E 5001 Related Classifications
HY-108516 Related Classifications
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