PROTAC BRD4 Degrader-41
PROTAC BRD4 Degrader-41 (Compound A5) is a BRD4 PROTAC degrader with a DC50 of 0.97 nM. PROTAC BRD4 Degrader-41 exhibits potent anti-proliferative activity against various types of cancer cells such as AML, lymphoma, breast cancer, ovarian cancer, and non-small cell lung cancer. PROTAC BRD4 Degrader-41 can induce G0/G1 phase arrest and apoptosis in MV4-11 cells. PROTAC BRD4 Degrader-41 downregulates the transcriptional level of c-Myc.
(Pink: BRD4 ligand (HY-78695); Blue: Cereblon ligand (HY-179735); Black: linker).
For research use only. We do not sell to patients.
- Formula: C43H51ClN8O5S
- Molecular Weight:827.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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BRD4 0.97 nM (DC50) |
Cereblon |
Chemical Information
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Molecular Weight 827.43
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Formula C43H51ClN8O5S
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SMILES
CC1=NN=C2[C@H](CC(NCCCCCCCCC(N[C@@H](CCC3=CC=CC=C3)C(NC4CCC(NC4=O)=O)=O)=O)=O)N=C(C5=CC=C(Cl)C=C5)C6=C(SC(C)=C6C)N21
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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