2. PROTAC Epigenetics Apoptosis
  3. PROTACs Epigenetic Reader Domain Apoptosis c-Myc
  4. PROTAC BRD4 Degrader-41

PROTAC BRD4 Degrader-41 (Compound A5) is a BRD4 PROTAC degrader with a DC50 of 0.97 nM. PROTAC BRD4 Degrader-41 exhibits potent anti-proliferative activity against various types of cancer cells such as AML, lymphoma, breast cancer, ovarian cancer, and non-small cell lung cancer. PROTAC BRD4 Degrader-41 can induce G0/G1 phase arrest and apoptosis in MV4-11 cells. PROTAC BRD4 Degrader-41 downregulates the transcriptional level of c-Myc.
(Pink: BRD4 ligand (HY-78695); Blue: Ligands for E3 Ligase ligand (HY-179735); Black: linker).

For research use only. We do not sell to patients.

PROTAC BRD4 Degrader-41

PROTAC BRD4 Degrader-41 Chemical Structure

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PROTAC BRD4 Degrader-41 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC BRD4 Degrader-41 (Compound A5) is a BRD4 PROTAC degrader with a DC50 of 0.97 nM. PROTAC BRD4 Degrader-41 exhibits potent anti-proliferative activity against various types of cancer cells such as AML, lymphoma, breast cancer, ovarian cancer, and non-small cell lung cancer. PROTAC BRD4 Degrader-41 can induce G0/G1 phase arrest and apoptosis in MV4-11 cells. PROTAC BRD4 Degrader-41 downregulates the transcriptional level of c-Myc[1]. (Pink: BRD4 ligand (HY-78695); Blue: Ligands for E3 Ligase ligand (HY-179735); Black: linker).

IC50 & Target[1]

BRD4

0.97 nM (DC50)

Cereblon

 

Molecular Weight

827.43

Formula

C43H51ClN8O5S
SMILES

CC1=NN=C2[C@H](CC(NCCCCCCCCC(N[C@@H](CCC3=CC=CC=C3)C(NC4CCC(NC4=O)=O)=O)=O)=O)N=C(C5=CC=C(Cl)C=C5)C6=C(SC(C)=C6C)N21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC BRD4 Degrader-41 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BRD4 Degrader-41PROTACsEpigenetic Reader DomainApoptosisc-MycMycacute myeloid leukemiaFLT3-ITD mutationCD15CD4CD10IMDM mediumIL-3GM-CSFG-CSFdrug screeningsignal pathway analysisInhibitorinhibitorinhibit

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