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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
48 Results for "
AIF
" in MedChemExpress (MCE) Product Catalog:
Products (48)
48 Results for "AIF" in MCE Product Catalog:
5
AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of arenavirus RNA synthesis, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research .
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4 Cited Publications
Cat. No.: HY-N0361
CAS No.: 19408-84-5
4
4 Cited Publications
Cat. No.: HY-N1910
CAS No.: 20784-60-5
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3 Cited Publications
Target:
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BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons .
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2 Cited Publications
Cat. No.: HY-N2166
CAS No.: 17406-45-0
Synonyms: α-Tomatine; Lycopersicin; Tomatin
Category:
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Ciglitazone is a potent and selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibits proliferation and differentiation of th17 cells. Ciglitazone is a hypoglycemic agent orally active in the obese-hyperglycemic animal models. Ciglitazone induces apoptosis accompanied by activation of p38 MAPK and nuclear translocation of apoptosis inducing factor (AIF) in opossum kidney (OK) renal epithelial cells .
1
1 Cited Publications
Cat. No.: HY-N4180
CAS No.: 55916-52-4
Cat. No.: HY-46866
CAS No.: 34348-59-9
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Cat. No.: HY-112817
CAS No.: 139307-94-1
Synonyms: 8-Oxo-Deoxyguanosine triphosphate
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Z-AEVD-FMK is a caspase-10 inhibitor. Z-AEVD-FMK can inhibit the activation of Bid and the release of apoptosis-inducing factor (AIF) in mitochondria in cells, resulting in a significant decrease in the number of apoptotic cells .
Cat. No.: HY-123554
CAS No.: 1186012-80-5
Flavagline FL3 is a flavagline with potent and selective cytotoxicity in cancer cells.Flavagline FL3 induces apoptosis of HL60 and Hela cells by triggering the translocation of Apoptosis Inducing Factor (AIF) and caspase-12 to the nucleus .
Synonyms: DHNQ (Standard); 5,8-Dihydroxy-1,4-naphthoquinone (Standard)
Category:
Quinones Juglandaceae Juglans sigillata Dode Phenols Polyphenols Plants Naphthalene Quinones
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Cat. No.: HY-59001
CAS No.: 94344-54-4
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Flavonoids Chalcones Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Disease Research Fields Cancer
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MKA031 (compound 6y) is a non-competitive MIF inhibitor with an IC50 value of 1.7 μM. MKA031 (compound 6y) interferes with MIF/AIF interaction, MIF nuclear translocation, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced dependent cell death. MKA031 can be used in the study of chronic hepatitis C virus infection .
Cat. No.: HY-N2166R
CAS No.: 17406-45-0
Synonyms: α-Tomatine (Standard); Lycopersicin (Standard); Tomatin (Standard)
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UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride induces apoptosis .
Cat. No.: HY-N10313
CAS No.: 53730-90-8
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Infection Triterpenes Terpenoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.
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Cat. No.: HY-N0361R
CAS No.: 19408-84-5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
