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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1774 Results for "
High affinity
" in MedChemExpress (MCE) Product Catalog:
Products (1774)
1774 Results for "High affinity" in MCE Product Catalog:
333
333 Publications Verification
Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727) . Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3 . Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice .
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77 Cited Publications
Cat. No.: HY-19370
CAS No.: 945714-67-0
Target:
연구분야:
FPS-ZM1 is a high-affinity and BBB-permeable RAGE inhibitor with a Ki of 25 nM.
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75 Cited Publications
Cat. No.: HY-P9907
CAS No.: 180288-69-1
Synonyms: Anti-Human HER2, Humanized Antibody
연구분야:
Trastuzumab is a humanized IgG1 monoclonal antibody that selectively binds to HER2 with high affinity. Trastuzumab can be used for the research of HER2-positive metastatic breast cancer and gastric cancer . (Note: The product specifications below only indicate the effective content of Trastuzumab. The component ratio of this product is Trastuzumab : excipients = 1:0.6-1:0.9.)
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Target:
연구분야:
Tariquidar (XR9576) is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1 nM) .
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61 Cited Publications
GSK484 hydrochloride is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor. GSK484 hydrochloride demonstrates high affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium. In the presence of 2 mM Calcium, notably lower potency (250 nM) is observed.
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Target:
연구분야:
Pioglitazone (U 72107) is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone can be used in diabetes research .
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56 Cited Publications
Synonyms: MC 903; Calcipotriene
Target:
Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
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56 Cited Publications
Target:
Calcipotriol monohydrate is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
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Target:
55
Category:
Cardiovascular Disease Alkaloids Natural Products Plant Neurological Disease Other Alkaloids Aconitum carmichaeli Debx. Extract Disease Research Fields Ranunculaceae Extract
Target:
46
46 Cited Publications
Cat. No.: HY-D0989
CAS No.: 145037-81-6
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45 Cited Publications
Target:
연구분야:
G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM .
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44 Cited Publications
Synonyms: 2'-3'-cyclic GMP-AMP
Target:
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44 Cited Publications
Synonyms: 2'-3'-cyclic GMP-AMP sodium
Target:
43
43 Cited Publications
ANA-12 is a brain-penetrant, selective TrkB antagonist with IC50 values of 45.6 nM and 41.1 μM, and Kd values of 10 nM and 12 μM, for high- and low-affinity sites, respectively. ANA-12 specifically inhibits BDNF-induced TrkB receptor activation and its downstream signaling cascades by directly and non-competitively binding to the TrkB receptor, without affecting the functions of TrkA and TrkC. ANA-12 is used in research concerning neuropsychiatric disorders (such as depression and anxiety), acute and chronic pain, neuroimmune inflammation, and the mechanisms of learning and memory .
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39 Cited Publications
Cat. No.: HY-W008719
CAS No.: 36913-39-0
Target:
연구분야:
MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .
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39 Cited Publications
Cat. No.: HY-19545A
CAS No.: 125941-87-9
Synonyms: R-(+)-SCH-23390 hydrochloride
연구분야:
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM .
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38 Cited Publications
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34 Cited Publications
Synonyms: Direct Blue 53; T-1824; C.I. 23860
Evans Blue (Direct Blue 53; T-1824; C.I. 23860) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability .
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Category:
Alkaloids Plant Zygophyllaceae Extract Nitrariaceae Extract Peganum harmala L. Extract Indole Alkaloids
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
