61 Results for "

Hypoglycemic activity

" in MedChemExpress (MCE) Product Catalog:
Products (61)

61 Results for "Hypoglycemic activity" in MCE Product Catalog:

13
Cucurbitacin B
Cucurbitacin B
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13 Publications Verification
Cat. No.: HY-N0416
CAS No.: 6199-67-3
Category:  

Triterpenes Terpenoids Cucurbitaceae Trichosanthes cucumerina L. Plants Endogenous metabolite Disease Research Fields Cancer

Target:  

HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX

Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .
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9
Lentinan
Lentinan
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9 Cited Publications
Cat. No.: HY-N6653
CAS No.: 37339-90-5
Category:  

Polysaccharides Agaricaceae Extract Lentinus edodes (Berk. ) Sing Plants Disease Research Fields Saccharides Cancer

Target:  

JAK Keap1-Nrf2 Apoptosis

Lentinan is an orally active biocompatible multifunctional polysaccharide with biological activities such as anti-inflammatory, antioxidant, immune regulation, anti-tumor, hypoglycemic, and lipid-lowering [1][4].
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3
Alliin
Alliin
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3 Cited Publications
Cat. No.: HY-N0661
CAS No.: 556-27-4
Category:  

Cardiovascular Disease Liliaceae Ketones, Aldehydes, Acids Plants Disease Research Fields  A．Sativam L. var．Viviparum Regel

Target:  

Others

Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities .
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3
Isoferulic acid
Isoferulic acid
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3 Cited Publications
Cat. No.: HY-N0761
CAS No.: 537-73-5
Synonyms: 3-Hydroxy-4-methoxycinnamic acid
Category:  

Metabolic Disease Plants  Cimicifuga foetida Linn. Ranunculaceae Extract Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Disease Research Fields Endocrinology

Target:  

Free Radical Scavengers Adrenergic Receptor Influenza Virus

Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is an orally active cinnamic acid derivative. Isoferulic acid exhibits hypoglycemic, antiviral, and antioxidant activities. Isoferulic acid can also inhibit fructose- and glucose-mediated protein glycation. Isoferulic acid can be used in the research of diseases such as diabetes .
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1
D-Pinitol
D-Pinitol
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1 Cited Publications
Cat. No.: HY-N0655
CAS No.: 10284-63-6
Synonyms: 3-O-Methyl-D-chiro-inositol
Category:  

Cardiovascular Disease Natural Products Glycine max (L.) merr Leguminosae Extract Plants Disease Research Fields Inflammation/Immunology

Target:  

Influenza Virus

D-pinitol (3-O-Methyl-D-chiro-inositol) is a natural compound presented in several plants, like Pinaceae and Leguminosae plants. D-pinitol exerts hypoglycemic activity and protective effects in the cardiovascular system . D-pinitol has antiviral and larvicidal activities .
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1
Swertiamarin
Swertiamarin
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1 Cited Publications
Cat. No.: HY-N0807
CAS No.: 17388-39-5
Category:  

Monophenols Metabolic Disease Phenols Zanthoxylum chiloperone var. angustifolium Plants Other Families Extract Disease Research Fields Cancer

Target:  

MMP NF-κB JAK Keap1-Nrf2

Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. Swertiamarin has antioxidant and hepatoprotective effects against carbon tetrachloride induced rat liver toxicity through the Nrf2/HO-1 pathway. Swertiamarin can attenuate inflammatory mediators by regulating JAK2/STAT3 transcription factors in adjuvant induced arthritis rats. Swertiamarin can be used in the research of diabetes and arthritis .
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1
Moringin
Moringin
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1 Cited Publications
Cat. No.: HY-N8264
CAS No.: 73255-40-0
Category:  

Natural Products Moringaceae Extract Neurological Disease Moringa oleifera Lam. Plants Disease Research Fields Inflammation/Immunology

Target:  

TRP Channel

Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .
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1
Carbutamide
Carbutamide
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1 Cited Publications
Cat. No.: HY-W011651
CAS No.: 339-43-5
Synonyms: BZ-55
Target:  

Phosphatase

Research Areas:  

Metabolic Disease

Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity .
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1
Stachyose hydrate
Stachyose hydrate
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1 Cited Publications
Cat. No.: HY-N0299
CAS No.: 54261-98-2
Category:  

Polysaccharides Scrophulariaceae Extract Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Disease Research Fields Inflammation/Immunology Saccharides

Target:  

Endogenous Metabolite Apoptosis

Stachyose hydrate is an orally active prebiotic that enhances the growth and activity of beneficial bacteria. Stachyose hydrate has hypoglycemic effects and can improve inflammation by regulating gut microbiota. In addition, Stachyose hydrate can induce plant cell apoptosis (Apoptosis). Stachyose hydrate can be used in research on inflammation, gastrointestinal diseases, and agriculture .
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1
Lixumistat acetate
Lixumistat acetate
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1 Cited Publications
Cat. No.: HY-136093A
CAS No.: 1422365-94-3
Purity:  99.88%
Synonyms: IM156; HL156A; HL271 acetate
Target:  

Mitochondrial Metabolism AMPK

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Lixumistat (IM156) acetate is a potent and orally active AMPK activator and OXPHOS inhibitor. Lixumistat acetate strongly activates AMPK, while it lacks the systemic metabolic regulatory effects of classic metformin, such as hypoglycemic and weight-lowering activities. Lixumistat acetate exhibits significant therapeutic effects on cognitive decline associated with brain aging and pulmonary fibrosis .
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1
Allyl methyl sulfide
Allyl methyl sulfide
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1 Cited Publications
Cat. No.: HY-128447
CAS No.: 10152-76-8
Purity:  ≥98.0%
Category:  

Infection Natural Products Liliaceae Plants Endogenous metabolite Disease Research Fields  A．Sativam L. var．Viviparum Regel

Target:  

Endogenous Metabolite SOD NF-κB GLUT

Allyl methyl sulfide is an orally active organic sulfide. Allyl methyl sulfide is one of the main active ingredients in garlic volatile metabolites. Allyl methyl sulfide can be extracted from garlic. Allyl methyl sulfide enhances SOD activity, inhibits NF-κB signaling pathway, and upregulates pancreatic GLUT2 expression. Allyl methyl sulfide has significant antioxidant, anti-inflammatory and hypoglycemic activities. Allyl methyl sulfide can be used in the research of diabetes and its complications .
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1
Lixumistat
Lixumistat
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1 Cited Publications
Cat. No.: HY-136093B
CAS No.: 1422365-93-2
Synonyms: IM156 free base; HL156A free base; HL271 free base
Target:  

Mitochondrial Metabolism AMPK

Research Areas:  

Neurological Disease Inflammation/Immunology

Lixumistat (IM156 free base) is a potent and orally active AMPK activator and OXPHOS inhibitor. Lixumistat strongly activates AMPK, while it lacks the systemic metabolic regulatory effects of classic metformin, such as hypoglycemic and weight-lowering activities. Lixumistat exhibits significant therapeutic effects on cognitive decline associated with brain aging and pulmonary fibrosis .
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1
Lixumistat hydrochloride
Lixumistat hydrochloride
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1 Cited Publications
Cat. No.: HY-136093
CAS No.: 1422365-52-3
Purity:  99.25%
Synonyms: HL271; IM156 hydrochloride; HL156A hydrochloride
Target:  

Mitochondrial Metabolism AMPK

Research Areas:  

Neurological Disease

Lixumistat (IM156) hydrochloride is a potent and orally active AMPK activator and OXPHOS inhibitor. Lixumistat hydrochloride strongly activates AMPK, while it lacks the systemic metabolic regulatory effects of classic metformin, such as hypoglycemic and weight-lowering activities. Lixumistat hydrochloride exhibits significant therapeutic effects on cognitive decline associated with brain aging and pulmonary fibrosis .
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Gomisin D
Gomisin D
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Cat. No.: HY-N2413
CAS No.: 60546-10-3
Category:  

Lignans Metabolic Disease Phenylpropanoids Plants Schisandraceae Extract Disease Research Fields Schisandra chinensis (Turcz.) Baill.

Target:  

PDGFR UGT Reactive Oxygen Species (ROS) Apoptosis Tyrosinase p38 MAPK Akt ERK COX Interleukin Related

Gomisin D is an orally active lignan that binds to PDGFRβ with a Kd of 10 μM. By targeting PDGFRβ to regulate signaling pathways, Gomisin D inhibits the activation and proliferation of hepatic stellate cells and promotes their apoptosis, thereby ameliorating hepatic fibrosis. Gomisin D exhibits multiple activities such as photoprotection, antimelanogenesis, antioxidant effects, and hypoglycemic activity. Gomisin D can be used in studies related to diabetes, Alzheimer's disease, and hepatic fibrosis .
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4-Pentenoic acid
4-Pentenoic acid
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Cat. No.: HY-Y0624
CAS No.: 591-80-0
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Mitochondrial Metabolism

4-Pentenoic acid is a medium-chain unsaturated fatty acid. 4-Pentenoic acid has hypoglycemic and fatty acid oxidation inhibitory activities. 4-Pentenoic acid can affect blood glucose metabolism and energy metabolism through mechanisms such as inhibiting long-chain fatty acid oxidation, reducing gluconeogenesis, and promoting glucose utilization .
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GLP-1R/GIPR agonist-1 (soduim)
GLP-1R/GIPR agonist-1 (soduim)
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Cat. No.: HY-P10302A
Target:  

GLP Receptor

Research Areas:  

Metabolic Disease Inflammation/Immunology

GLP-1R/GIPR agonist-1 sodium is a dual GLP-1/GIP receptor agonist, with an EC50 of 0.57 nM for GLP-1R and an EC50 of 0.75 nM for GIPR. GLP-1R/GIPR agonist-1 sodium reduces food intake, inhibits weight gain, repairs islet damage, improves glucose tolerance, regulates serum lipid and liver enzyme levels, ameliorates hepatic vacuolization, reduces hepatic fat accumulation, delays the progression of hepatic fibrosis, and exhibits long-lasting hypoglycemic activity. GLP-1R/GIPR agonist-1 sodium can be used in research related to type 2 diabetes, obesity, and non-alcoholic steatohepatitis .
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Vitisin A
Vitisin A
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Cat. No.: HY-142026
CAS No.: 142449-89-6
Synonyms: (+)-Vitisin A
Category:  

Vitaceae Extract Vitis vinifera cv. Zalema Phenols Polyphenols Plants

Target:  

Caspase ERK NF-κB Influenza Virus PAK LDLR PPAR PCSK9 Androgen Receptor Keap1-Nrf2 Monoamine Oxidase Cholinesterase (ChE) IKK Wnt β-catenin Reactive Oxygen Species (ROS) Apoptosis Cuproptosis

Vitisin A ((+)-Vitisin A) is an orally active natural product with multiple pharmacological activities including anti-inflammatory, anti-tumor, anti-oxidant, anti-pathogenic microorganism, hypoglycemic and lipid-regulating, anti-osteoporotic, neuroprotective and cardiovascular protective effects. Vitisin A exhibits inhibitory effects on human AChE and MAO-B with IC50 values of 1.29 µM and 4.94 µM, respectively. Vitisin A inhibits the ERK, MAPK, NF-κB, STAT1, HMGCR and TRAF6 pathways, downregulates the related phosphorylation and protein expression, while activates the Nrf2/HO-1 pathway and upregulates p21 expression. Vitisin A induces tumor cell apoptosis and cell cycle arrest, inhibits adipogenesis and lipid accumulation, while alleviates oxidative stress, suppresses inflammatory responses, blocks hepatic fibrosis, Cuproptosis and cholesterol synthesis, and increases the expression levels of central BDNF and TrkB. Vitisin A can be used in the research of tumors, infectious diseases, metabolic diseases, bone and joint diseases, liver diseases, skin injuries, as well as neurodegenerative and cognitive dysfunction-related diseases .
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Pongamol
Pongamol
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Cat. No.: HY-121811
CAS No.: 484-33-3
Purity:  99.81%
Synonyms: Lanceolatin C
Category:  

Pongamia pinnata (L.) Pierre Ketones, Aldehydes, Acids Derris trifoliata Lour. Leguminosae Extract Plants

Target:  

Glycosidase Phosphatase Interleukin Related TNF Receptor COX Beclin1 GLUT FAK Akt mTOR p38 MAPK Keap1-Nrf2 Apoptosis Amyloid-β Tau Protein Autophagy

Pongamol (Lanceolatin C) is an orally active flavonoid with an IC50 of 75 μM and a Ki of 58 μM against PTPase-1B, and an IC50 of 103.5 μM against intestinal α-Glycosidase. Pongamol reduces the release of IL‑1β, TNF‑α, COX‑2 and iNOS in cells, reverses the nuclear translocation of NF‑κB, and upregulates the levels of Beclin 1 and LC3 Ⅱ/LC3 Ⅰ. Pongamol promotes glucose uptake by increasing the level of GLUT4 on the surface of skeletal muscle cells. Pongamol inhibits epithelial-mesenchymal transition by suppressing the FAK/Akt-mTOR signaling pathway. Pongamol inhibits neuronal cytotoxicity, suppresses cell apoptosis and extends the lifespan of Caenorhabditis elegans by activating the MAPKs/Nrf2 signaling pathway. Pongamol exerts hypoglycemic effects in diabetic mouse models. Pongamol exhibits antibacterial activity. Pongamol alleviates oxidative stress, neuroinflammation, Aβ deposition and excessive phosphorylation of Tau Protein, and restores autophagy function in Alzheimer's disease mouse models by inhibiting the Akt/mTOR signaling pathway. Pongamol is applicable to research related to Alzheimer's disease, type 2 diabetes, non-small cell lung cancer and postprandial hyperglycemia .
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Amorfrutin B
Amorfrutin B
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Cat. No.: HY-113631
CAS No.: 78916-42-4
Category:  

Monophenols Phenols Amorpha fruticosaL. Leguminosae Extract Plants

Target:  

PPAR

Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities .
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Cucurbitacin B (Standard)
Cucurbitacin B (Standard)
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Cat. No.: HY-N0416R
CAS No.: 6199-67-3
Category:  

Triterpenes Terpenoids Cucurbitaceae Trichosanthes cucumerina L. Plants Endogenous metabolite

Target:  

HIF/HIF Prolyl-Hydroxylase Reference Standards Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX

Cucurbitacin B (Standard) is the analytical standard of Cucurbitacin B. This product is intended for research and analytical applications. Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .
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