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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
231 Results for "
RAW macrophages
" in MedChemExpress (MCE) Product Catalog:
Products (231)
231 Results for "RAW macrophages" in MCE Product Catalog:
162
162 Publications Verification
Target:
Research Areas:
JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .
16
16 Cited Publications
Synonyms: Indole-3-lactic acid
Category:
Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields
Target:
10
3
3 Cited Publications
Cat. No.: HY-N6893
CAS No.: 54999-07-4
2
2 Cited Publications
Cat. No.: HY-N0569
CAS No.: 18449-41-7
2
2 Cited Publications
Cat. No.: HY-N4137
CAS No.: 13850-16-3
Category:
Cardiovascular Disease Triterpenes Terpenoids Rosaceae Plants Disease Research Fields Rosa rugosa Thunb.
Target:
2
1
1 Cited Publications
Synonyms: 4-Hydroxy-3-methoxycinnamaldehyde
Category:
other families Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
Cat. No.: HY-W082785A
CAS No.: 24533-47-9
Target:
TNF Receptor Interleukin Related Toll-like Receptor (TLR) NF-κB NOD-like Receptor (NLR) Apoptosis Caspase Bcl-2 Family Reactive Oxygen Species (ROS)
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low KD value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC50 values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research .
1
1 Cited Publications
Cat. No.: HY-N7012
CAS No.: 29080-58-8
Synonyms: 5-Hydroxy-3',4',7-trimethoxyflavone
1
1 Cited Publications
Category:
Natural Products Plants Brassicaceae Disease Research Fields Inflammation/Immunology Rorippa indica (L.) Hiern
Target:
1
1
1
1 Cited Publications
Cat. No.: HY-N0853A
CAS No.: 18674-16-3
Synonyms: Alisol A 24-monoacetate; Alisol A monoacetate
1
1 Cited Publications
Cat. No.: HY-N0854
CAS No.: 155521-45-2
1
1 Cited Publications
Category:
Bletilla striata (Thunb. ex Murray) Rchb. f. Orchidaceae Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields
Target:
1
Category:
1
Category:
Quinones Monophenols Anthraquinones Rubiaceae Metabolic Disease Phenols Plants Disease Research Fields Rubia cordifolia L.
Target:
1
1
1 Cited Publications
Synonyms: VTP-43742 hydrochloride
Target:
Research Areas:
Vimirogant hydrochloride (VTP-43742 hydrochloride) is a potent, selective, and orally active RORγt inhibitor with a Ki of 3.5 nM for binding to RORγt. VTP-43742 blocks Th17 cell differentiation and reduces IL-17A production by inhibiting RORγt-mediated transcriptional activity, thereby suppressing the RORγt/Th17/IL-17 inflammatory axis. VTP-43742 can be used for research on autoimmune diseases and inflammation-related diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
