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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
157 Results for "
aldose
" in MedChemExpress (MCE) Product Catalog:
Products (157)
157 Results for "aldose" in MCE Product Catalog:
35
35 Publications Verification
別名: GU17; ISL; Isoliquiritigen; SJ000286237
11
11 Cited Publications
製品番号: HY-N0033
CAS 番号: 94079-81-9
Category:
Cardiovascular Disease Callicarpa formosana Rolfe Plants Simple Phenylpropanols Verbenaceae Scrophulariaceae Phenols Polyphenols Phenylpropanoids Disease Research Fields Inflammation/Immunology Brandisia hancei Hook. f.
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8
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Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy .
3
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研究分野:
Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.
3
3 Cited Publications
製品番号: HY-B1392
CAS 番号: 81161-17-3
Esmolol hydrochloride is an ultra-short-acting cardioselective β1-adrenergic blocker. Esmolol hydrochloride exerts its antiarrhythmic effect by activating Neurokinin 1 Receptor. Esmolol hydrochloride attenuates post resuscitation myocardial dysfunction. Esmolol hydrochloride improves diabetic wound healing by inhibiting aldose reductase and the production of advanced glycation end products and promoting fibroblast migration. Esmolol hydrochloride can be used to study cardiac diseases such as arrhythmias and diabetic foot ulcers .
2
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研究分野:
Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM.
2
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Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.
2
2 Cited Publications
製品番号: HY-50289
CAS 番号: 68367-52-2
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研究分野:
Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.
2
2 Cited Publications
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研究分野:
Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac . Exisulind inhibits aldose reductase with an IC50 of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications .
2
2 Cited Publications
製品番号: HY-N0311
CAS 番号: 23313-21-5
Category:
Quinones other families Anthraquinones Phenols Polyphenols Plants Disease Research Fields Cancer
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1
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研究分野:
Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications .
1
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研究分野:
Alrestatin (AY-22284) is an aldose reductase inhibitor. Alrestatin reduces fructose levels in the uterine fluid of mice. Alrestatin interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin can be used in studies related to diabetes and reproductive diseases .
1
1 Cited Publications
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Zenarestat is a potent and orally active aldose reductase inhibitor. Zenarestat improves diabetic peripheral neuropathy in Zucker diabetic fatty rats .
1
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研究分野:
Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol .
1
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Ranirestat (AS-3201) potent and orally active aldose reductase (AR) inhibitor with IC50s of 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively, and a Ki of 0.38 nM for recombinant human AR. Ranirestat has the potential for diabetic sensorimotor polyneuropathy treatment. Ranirestat also has a neuroprotective effect on diabetic retinas .
1
1 Cited Publications
製品番号: HY-N0309
CAS 番号: 114590-20-4
1
1 Cited Publications
別名: Glucogallin; 1-O-Galloyl-β-D-glucose
1
1 Cited Publications
製品番号: HY-N0310
CAS 番号: 51330-27-9
1
Category:
Rudbeckia laciniata L. Ketones, Aldehydes, Acids Plants Umbelliferae Endogenous metabolite Disease Research Fields Cancer
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Category:
Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Saccharides Monosaccharides
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
