1679 Results for "

veratramine-type isosteroidal alkaloid

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Berberine chloride

83 Cited Publications

Cat. No.: HY-18258

CAS No.: 633-65-8

Synonyms: Natural Yellow 18 chloride

Category:

Alkaloids Phellodendron amurense Rupr. Rutaceae Plants Disease Research Fields Isoquinoline Alkaloids Biological Pesticide Research Cancer Agricultural Research

Target:

Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite

Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

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Berberine sulfate

80 Cited Publications

Cat. No.: HY-N0716B

CAS No.: 633-66-9

Synonyms: Natural Yellow 18 sulfate

Category:

Alkaloids Ranunculaceae Coptis chinensis Franch. Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology

Target:

Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB

Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .

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Colchicine

77 Cited Publications

Cat. No.: HY-16569

CAS No.: 64-86-8

Category:

Natural Products other families Plants Disease Research Fields Cancer

Target:

Environmental Pollutants Apoptosis Autophagy Microtubule/Tubulin NOD-like Receptor (NLR)

Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

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Berberine chloride hydrate

77 Cited Publications

Cat. No.: HY-17577

CAS No.: 68030-18-2

Synonyms: Natural Yellow 18 chloride hydrate

Category:

Alkaloids Ranunculaceae Coptis chinensis Franch. Plants Disease Research Fields Isoquinoline Alkaloids Cancer

Target:

Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite

Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

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Camptothecin

73 Cited Publications

Cat. No.: HY-16560

CAS No.: 7689-03-4

Synonyms: Campathecin; (S)-(+)-Camptothecin; CPT

Category:

Infection Alkaloids Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields

Target:

Topoisomerase ADC Payloads MicroRNA Influenza Virus Apoptosis Fungal Antibiotic

Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM . Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .

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Berberine hemisulfate

54 Cited Publications

Cat. No.: HY-N0716A

CAS No.: 316-41-6

Synonyms: Natural Yellow 18 hemisulfate

Category:

Infection Alkaloids Ranunculaceae Coptis chinensis Franch. Metabolic Disease Plants Disease Research Fields Isoquinoline Alkaloids Cancer

Target:

Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB

Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity .

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Monocrotaline

48 Cited Publications

Cat. No.: HY-N0750

CAS No.: 315-22-0

Synonyms: Crotaline

Category:

Alkaloids Pyrrole Alkaloids Leguminosae Plants Crotalaria pallida Ait. Disease Research Fields Cancer

Target:

Others

Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC₅₀s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. ^[2][6][8].

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Dehydrocorydaline chloride

47 Cited Publications

Cat. No.: HY-N0674A

CAS No.: 10605-03-5

Synonyms: 13-Methylpalmatine chloride

Category:

Infection Alkaloids other families Plants Disease Research Fields Isoquinoline Alkaloids

Target:

Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy

Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

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Dehydrocorydaline

47 Cited Publications

Cat. No.: HY-N0674

CAS No.: 30045-16-0

Synonyms: 13-Methylpalmatine

Category:

Infection Alkaloids Corydalis yanhusuo W. T. Wang Plants Disease Research Fields Isoquinoline Alkaloids Papaveraceae

Target:

Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy

Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

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Dehydrocorydaline (hydroxyl)

46 Cited Publications

Cat. No.: HY-N0674B

Synonyms: 13-Methylpalmatine (hydroxyl)

Category:

Alkaloids Corydalis yanhusuo W. T. Wang Plants Papaveraceae

Target:

Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy

Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

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Dehydrocorydaline nitrate

45 Cited Publications

Cat. No.: HY-N4238

CAS No.: 13005-09-9

Synonyms: 13-Methylpalmatine nitrate

Category:

Infection Alkaloids other families Plants Disease Research Fields Isoquinoline Alkaloids

Target:

Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy

Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. . Dehydrocorydaline nitrate shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

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Bicuculline

42 Cited Publications

Cat. No.: HY-N0219

CAS No.: 485-49-4

Synonyms: (+)-Bicuculline

Category:

Alkaloids Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae

Target:

GABA Receptor

Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABA_A receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca ²⁺ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

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Homoharringtonine

37 Cited Publications

Cat. No.: HY-14944

CAS No.: 26833-87-4

Purity: 99.75%

Synonyms: Omacetaxine mepesuccinate; HHT

Category:

Alkaloids Pyrrole Alkaloids Plants Cephalotaxaceae Disease Research Fields Cancer Cephalotaxus fortunei Hooker

Target:

STAT

Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.

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Lycorine

25 Cited Publications

Cat. No.: HY-N0288

CAS No.: 476-28-8

Category:

Alkaloids other families Pyrrole Alkaloids Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Amaryllidaceae

Target:

Fatty Acid Synthase (FASN) Virus Protease Bacterial Apoptosis

Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a K_d value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription . Lycorine is also a melanoma vasculogenic inhibitor . Lycorine can be used for the study of prostate cancer and metabolic diseases .

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Sinomenine

23 Cited Publications

Cat. No.: HY-15122

CAS No.: 115-53-7

Purity: 99.94%

Category:

Neurological Disease Sinomenium acutum(Thunb．)Rehd．Et Wils． Plants Menispermaceae Alkaloids Piperidine Alkaloids Monophenols Phenols Disease Research Fields Inflammation/Immunology

Target:

NF-κB Opioid Receptor Autophagy Apoptosis

Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of μ-opioid receptor .

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Sinomenine hydrochloride

23 Cited Publications

Cat. No.: HY-15122A

CAS No.: 6080-33-7

Purity: 99.89%

Synonyms: Cucoline hydrochloride

Category:

Neurological Disease Sinomenium acutum(Thunb．)Rehd．Et Wils． Plants Menispermaceae Alkaloids Piperidine Alkaloids Monophenols Phenols Disease Research Fields Inflammation/Immunology

Target:

NF-κB Opioid Receptor Autophagy Apoptosis

Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of μ-opioid receptor .

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Oxymatrine

23 Cited Publications

Cat. No.: HY-N0158

CAS No.: 16837-52-8

Category:

Infection Alkaloids Piperidine Alkaloids Leguminosae Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology

Target:

TGF-beta/Smad Apoptosis

Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection .

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Liensinine Diperchlorate

22 Cited Publications

Cat. No.: HY-N0485

CAS No.: 5088-90-4

Category:

Cardiovascular Disease Alkaloids Piperidine Alkaloids Phenols Polyphenols Nelumbo nucifera Gaertn. Plants Disease Research Fields Nymphaeaceae

Target:

Autophagy Mitophagy

Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

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Liensinine

22 Cited Publications

Cat. No.: HY-N0484

CAS No.: 2586-96-1

Category:

Cardiovascular Disease Alkaloids other families Phenols Polyphenols Plants Disease Research Fields Alkaloid Dimers

Target:

Reactive Oxygen Species (ROS) Autophagy Apoptosis VEGFR JAK Amyloid-β p38 MAPK HIF/HIF Prolyl-Hydroxylase STAT PI3K JNK Akt

Liensinine is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine activates AMPK and inhibits the expression of HIF-1α and VEGF, thereby suppressing angiogenesis. Liensinine exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke .

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Liensinine perchlorate

22 Cited Publications

Cat. No.: HY-N5014

CAS No.: 2385-63-9

Category:

Alkaloids other families Phenols Polyphenols Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology

Target:

Reactive Oxygen Species (ROS) Autophagy Apoptosis VEGFR JAK Amyloid-β p38 MAPK HIF/HIF Prolyl-Hydroxylase STAT PI3K JNK Akt

Liensinine perchlorate is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine perchlorate suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine perchlorate activates AMPK and inhibits the expression of HIF-1α and VEGF, thereby suppressing angiogenesis. Liensinine perchlorate exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine perchlorate can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke .

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