NO Synthase
Nitric oxide synthases; NOS
Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.
NO Synthase Isoform Specific Products
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NO Synthase Inhibitors
(755)
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NO Synthase Agonists
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NO Synthase Antagonists
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NO Synthase Activators
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NO Synthase Modulators
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NO Synthase MDM2 Inhibitor
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NO Synthase Inducers
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NO Synthase Controls
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NO Synthase Substrates
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NO Synthase Ligand
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NO Synthase Related Products (1009)
Related Products (1009)
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Antibodies (6)
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NO Synthase Isoform Comparison
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Tetrandrine 2'-N-α-oxide
0 ImagesCat. No.: HY-N17761CAS No.: 90365-80-3Tetrandrine 2'-N-α-oxide (compound 13) is a bisbenzylisoquinoline alkaloid anti-inflammatory agent that can be isolated from the roots of Stephania tetrandra. Tetrandrine 2'-N-α-oxide may be used in research related to inflammatory diseases.
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Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside
0 ImagesCat. No.: HY-N18025CAS No.: 131559-50-7Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside is an anti-inflammatory agent. Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside exerts significant anti-inflammatory effects in LPS (HY-D1056)-induced RAW 264.7 macrophages by inhibiting the NF-κB, MAPK and Akt signaling pathways, thereby reducing the production of inflammatory mediators (NO, PGE2) and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6).
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Myricananin A
0 ImagesCat. No.: HY-N3226CAS No.: 1079941-35-7Myricananin A is a colorless needle that has inhibitory effect on iNOS.
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Antrodin D
0 ImagesCat. No.: HY-N12368CAS No.: 656832-04-1Antrodin D is an iNOS inhibitor isolated and extracted from the mycelium of Antrodia camphorata. Antrodin D inhibits LPS (HY-D1056)-induced nitric oxide production in macrophages. Antrodin D can be used for research on inflammatory diseases.
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Isochiisanoside
0 ImagesCat. No.: HY-N21863CAS No.: 105591-35-3Isochiisanoside is a lupane-type triterpenoid triglycoside found in the leaves of Acanthopanax sessiliflorus. Isochiisanoside dose-dependently inhibits LPS (HY-D1056A1))-induced NO (IC50 = 64.25 μM) and PGE2 production in macrophages without obvious cytotoxicity. Isochiisanoside shows weak inhibitory activity against porcine pancreatic lipase. Isochiisanoside can be used in inflammation-related research.
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L-Arginine arginine
0 ImagesCat. No.: HY-N0455CCAS No.: 37466-21-0L-Arginine arginine is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis.
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Cyanidin 3,5-diglucoside chloride (Standard)
0 ImagesCat. No.: HY-129138RCAS No.: 2611-67-8Cyanidin 3,5-diglucoside (chloride) (Standard) is the analytical standard of Cyanidin 3,5-diglucoside (chloride) (HY-129138). This product is intended for research and analytical applications. Cyanidin 3,5-diglucoside chloride is an anthocyanin. Cyanidin 3,5-diglucoside chloride inhibits inflammatory cytokines (IL-1α, IL-1β, and IL-6) expression and NO production. Cyanidin 3,5-diglucoside chloride inhibits the phosphorylation of STAT3, IκB, ERK, p38, and AKT. Cyanidin 3,5-diglucoside chloride inhibits high pressure-induced decrease in GLAST. Cyanidin 3,5-diglucoside chloride exerts anti-inflammatory and skin barrier modulating effects. Cyanidin 3,5-diglucoside chloride can be used in retinal research.
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Morachalcone A
0 ImagesCat. No.: HY-N3246CAS No.: 76472-88-3Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production.
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Chloranthalactone E
0 ImagesCat. No.: HY-N10865CAS No.: 73215-92-6Chloranthalactone E (compound 6), a labdane diterpene, can be isolated from the aerial parts of Chloranthus serratus. Chloranthalactone E inhibits NO production in LPS-activated RAW 264.7 macrophages.
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LA-419
0 ImagesCat. No.: HY-19392CAS No.: 263754-93-4LA-419 is an orally active nitric oxide (NO) donor. LA-419 can significantly reduce the amount of fecal worm eggs excreted, shorten the duration of egg excretion, and also decrease the number of larvae in the lungs and the number of parasitic females in the intestines in mice infected with S. venezuelensis. LA-419 can reduce the formation of atherosclerosis in apolipoprotein E-deficient mice. LA-419 can be used for the researches of infection and cardiovascular disease.
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Estetrol-d3
0 ImagesCat. No.: HY-W744272Estetrol-d3 is the deuterium labeled Estetrol (HY-15731). Estetrol, an orally active estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear?estrogen receptor?modulator. Estetrol binds?ERα?as well as?ERβ?(with a fourfold lower affinity). Estetrol increases?eNOS?expression/activity and NO synthesis in endothelial cells. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast. Estetrol can be used in contraception and menopausal hormone research.
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MBL-1
0 ImagesCat. No.: HY-N6189CAS No.: 1815632-13-3MBL-1 is an orally active anti-inflammatory agent. MBL-1 can be isolated from the fermentation broth of Aspergillus sp. derived from gorgonians. MBL-1 inhibits the activity of the hCOX-2 protein with an IC50 of 5.77 μM. MBL-1 reduces the production of key pro-inflammatory mediators such as NO, ROS, IL-1β and IL-18 by inhibiting the MAPK/NF-κB and NLRP3 signaling pathways. MBL-1 exerts a protective effect against DSS-induced colitis. MBL-1 can be used for the research of ulcerative colitis.
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Mercaptoethylguanidine (MEG) dihydrobromide
0 ImagesCat. No.: HY-115744CAS No.: 32665-11-5Mercaptoethylguanidine (MEG) dihydrobromide is selective inhibitor of the inducible nitric oxide synthase and peroxynitrite scavenger. Mercaptoethylguanidine (MEG) dihydrobromide has the potential for inflammatory bowel diseases research.
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NLRP3-IN-76
0 ImagesCat. No.: HY-170218NLRP3-IN-76 is an orally active NLRP3 inhibitor. NLRP3-IN-76 inhibits the production of NO, and the mRNA levels of proinflammatory cytokines (iNOS, IL-6, IL-1β and TNFα). NLRP3-IN-76 shows anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome and NF-κB signaling pathway. NLRP3-IN-76 ameliorates DSS (HY-116282C)-induced colitis and can be used for research of inflammatory bowel diseases (IBD).
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Dimeric coniferyl acetate
0 ImagesCat. No.: HY-N3760CAS No.: 184046-40-0Dimeric coniferyl acetate is a NO production inhibitor with an IC50 value 7.9 μM in BV-2 microglial cells.
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Isosilychristin
0 ImagesCat. No.: HY-184830CAS No.: 77182-66-2Isosilychristin is a P-glycoprotein inhibitor with an IC50 of 25.9 μM. Isosilychristin downregulates the expression of transmembrane efflux pumps, exerts intracellular antioxidant effects, and inhibits NO production in macrophages. Isosilychristin regulates cell cycle progression, and exerts weak antiproliferative and colony formation inhibitory effects in prostate cancer cells. Isosilychristin reduces bacterial intercellular communication and reverses the drug resistance of Staphylococcus aureus. Isosilychristin can be used in studies related to prostate cancer, inflammation and bacterial infections.
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Akt/NF-κB/MAPK-IN-1
0 ImagesCat. No.: HY-149496CAS No.: 2994215-72-2Akt/NF-κB/MAPK-IN-1 (compound 2m) is a potent and orally active inhibitor against NO (IC50=7.70 μM) with no significant toxicity. Akt/NF-κB/MAPK-IN-1 shows anti-inflammatory activity by inhibiting Akt/NF-κB and MAPK signaling pathways.
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rel-Cleroindicin F
0 ImagesCat. No.: HY-N3602ACAS No.: 94535-01-0Synonyms: Rengyolonerel-Cleroindicin F (Rengyolone) is a cyclohexyl acetyl compound that can be isolated from the fruit of forsythia and has anti-inflammatory activity. It strongly inhibits the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). rel-Cleroindicin F does this by downregulating the activity of NF-κB and NF-κB kinases in RAW 264.7 cells stimulated by LPS (HY-D1056), thus inhibiting the expression of inducible nitric oxide synthase (NO Synthase) and nitric oxide production.
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YPX-C-05
0 ImagesYPX-C-05 is an orally active HDAC inhibitor and vasodilator. YPX-C-05 inhibits HDAC enzymatic activity, increases histone H4 acetylation, activates the PI3K/Akt pathway, promotes Akt and eNOS phosphorylation, enhances eNOS activity, and boosts nitric oxide production. YPX-C-05 increases Tetrahydrobiopterin (HY-107383) levels, restores serum nitric oxide levels, reduces endothelin-1 levels, and improves endothelial function. YPX-C-05 reduces vascular remodeling and exerts antihypertensive effects in hypertensive Mus musculus mice. YPX-C-05 can be used for the research of hypertension.
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Pulegone-d8
0 ImagesCat. No.: HY-N1500S1CAS No.: 62385-90-4Pulegone-d8 is deuterated labeled Pulegone (HY-N1500). Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species.
