Akt/NF-κB/MAPK-IN-1
Akt/NF-κB/MAPK-IN-1 (compound 2m) is a potent and orally active inhibitor against NO (IC50=7.70 μM) with no significant toxicity. Akt/NF-κB/MAPK-IN-1 shows anti-inflammatory activity by inhibiting Akt/NF-κB and MAPK signaling pathways.
For research use only. We do not sell to patients.
- CAS No.: 2994215-72-2
- Formula: C38H56N2O4
- Molecular Weight:604.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
IL-1β |
IL-6 |
iNOS |
COX-2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
7.7 μM
Compound: 2m
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Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs
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[PMID: 37678142] |
Akt/NF-κB/MAPK-IN-1 (compound 2m) (0-20 μM, 24 h) significantly decreases the levels of TNF-α, IL-1β, IL-6 and PGE2, down-regulates the expression of iNOS and COX-2 in LPS (10 ng/mL)-induced RAW264.7 cells[1].
Akt/NF-κB/MAPK-IN-1 (0-20 μM, 24 h) can block LPS-induced phosphorylation of p38, ERK and JNK in RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male ICR mice (weighing 20-25 g)[1]
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Dosage:10 and 20 mg/kg
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Administration:Intragastric administration, for 7 consecutive days, and then LPS was intraperitoneally injected
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Result:The levels of IL-6, IL-1β and TNF-α in the LPS group were significantly increased compared to the control group, and the administration of 2m effectively prevented the increase.
Chemical Information
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CAS No. 2994215-72-2
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Molecular Weight 604.86
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Formula C38H56N2O4
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SMILES
O[C@@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(N4CCN(CC4)C(/C=C/C5=CC=C(C=C5)C)=O)=O)(CC[C@]2([H])[C@@]6([C@](C[C@@H](CC6)O)([H])C1)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Akt/NF-κB/MAPK-IN-1 Related Classifications
HY-149496 Related Classifications
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