Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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5'-Deoxy-5-fluorocytidine
0 ImagesSynonyms: 5-Fluoro-5'-deoxycytidine5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer.
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2'-O-Methylinosine
0 Images2'-O-Methylinosine is a derivative of 2'-O-Methyladenosine. 2'-O-Methylinosine can be formed by chemical deamination of unmethylated 2'-O-Methyladenosine (HY-W011552). 2'-O-Methylinosine does not induce spore germination in Bacillus cereus. 2'-O-Methylinosine can be used in studies on diabetic nephropathy and HIV infection.
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2’-Deoxy-N4-methylcytidine
0 Images2’-Deoxy-N4-methylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Orotic acid-13C,15N2 monohydrate
0 ImagesSynonyms: 6-Carboxyuracil-13C,15N2 monohydrate; Vitamin B13-13C,15N2 monohydrateOrotic acid-13C,15N2 (monohydrate) is the 13C and 15N labeled Orotic acid. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats.
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5-Azidomethyl-2'-deoxyuridine
0 ImagesSynonyms: 5-AmdU; α-Azidothymidine5-Azidomethyl-2'-deoxyuridine (5-AmdU) is a purine nucleoside analog. 5-Azidomethyl-2'-deoxyuridine demonstrates effective radiosensitization in EMT6 tumor cells.. 5-Azidomethyl-2'-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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1,2-Dideoxy-D-ribofuranose
0 Images1,2-Dideoxy-D-ribofuranose is a monomeric raw material that can be used for nucleic acid synthesis.
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Acyclovir triphosphate sodium (100 mM)
0 ImagesSynonyms: AcycloGTP sodium (100 mM)Acyclovir triphosphate (Synonyms: AcycloGTP) sodium is a Acyclovir (HY-17422) derivative that competitively inhibits viral DNA polymerase by acting as an analog to deoxyguanosine triphosphate (dGTP). Acyclovir triphosphate (sodium) (100 mM) is an inhibitor of HIV-1 reverse transcriptase. Acyclovir triphosphate (sodium) (100 mM) causes termination of viral DNA synthesis.
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4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione
![4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione](https://file.medchemexpress.com/product_pic/hy-w102981.gif "Click to View 4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione Product Detail")
0 ImagesCat. No.: HY-W102981CAS No.: 5426-09-5Synonyms: 7-Oxanorborna-2-ene-5,6-dicarboxylic anhydride4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2'-Deoxycytidine (hydrochloride)
0 ImagesSynonyms: 2'-Deoxycytidine monohydrochloride; Deoxycytidine hydrochloride; NSC 832512'-Deoxycytidine hydrochloride (2'-Deoxycytidine monohydrochloride; NSC 83251) is an orally active nucleic acid biosynthesis enzyme inhibitor. 2'-Deoxycytidine hydrochloride competes with nucleic acid biosynthesis enzymes and nucleoside transporters, thereby reducing the toxicity of cytarabine. 2'-Deoxycytidine hydrochloride can be used in the research of L1210 lymphoblastic leukemia.
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Cytidine-13C9
0 ImagesCat. No.: HY-B0158S7Purity: 98.69%Synonyms: Cytosine β-D-riboside-13C9; Cytosine-1-β-D-ribofuranoside-13C9Cytidine-13C9 (Cytosine β-D-riboside-13C9) is 13C labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
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5,6-Dihydro-5-Fluorouracil
0 ImagesSynonyms: 5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione; 5-Fluorodihydrouracil5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50=13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model.
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Adenosine 3′-monophosphate
0 ImagesSynonyms: 3′-AMPAdenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors.
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(2S,3AS,7aS)-Octahydroindole-2-carboxylic acid
0 Images(2S,3aS,7aS)-Octahydroindole-2-carboxylic acid is a bicyclic hydrophobic proline analog that acts as a polyproline-II helix stabilizer. (2S,3aS,7aS)-Octahydroindole-2-carboxylic acid serves as a structural component of Perindopril (HY-B0130). (2S,3aS,7aS)-Octahydroindole-2-carboxylic acid can be used in studies related to organic synthesis.
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3'-ONH2-dATP sodium solution (100 mM)
0 ImagesCat. No.: HY-158712Purity: 99.0%3'-ONH2-dATP sodium solution (100mM) is a 3'-O-blocked reversible terminator deoxynucleotide triphosphate. 3'-ONH2-dATP sodium solution (100mM) stops DNA polymerization after single-nucleotide addition to an initiator strand, and its 3'-ONH2 blocking group can be removed to restore a free 3'-OH for subsequent extension.
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Tiazofurin
0 ImagesSynonyms: NSC 286193; RiboxamideTiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin enhances the autosecretion of IL-6 in K562 cells. Tiazofurin also has anti-orthopoxvirus and anti-variola activities. Tiazofurin can be used for the study of leukemia and lung cancer.
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Sapacitabine
0 ImagesSynonyms: CS682; CYC682Sapacitabine is an orally available nucleoside analog proagent that is structurally related to cytarabine.
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N4-Benzoyl-2’-O-methylcytidine
0 ImagesN4-Benzoyl-2’-O-methylcytidine is a natural cytidine nucleoside analog. Cytidine analogs have the mechanism of inhibiting DNA methyltransferase (such as Zebularine (HY-13420)) and have potential antimetabolite and antitumor activities.
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2-Thiocytidine
0 Images2-Thiocytidine is a natural thionucleoside in prokaryotic tRNA, which is biosynthesized under the catalysis of intracellular sulfur transferase systems and possesses multiple activities such as metal coordination and nucleic acid conformation regulation. 2-Thiocytidine forms stable Zn2+ and Cd2+ complexes via its (C2) S group, with partial involvement of N3; metal binding acidifies the deprotonation process of (C4) NH2. 2-Thiocytidine can be used in related research in various fields including nanotechnology and click chemistry for interstrand DNA crosslinking.
