2. Signaling Pathways
  3. Epigenetics
    TGF-beta/Smad
  4. PKC

PKC

Protein kinase C

PKC

Related Products

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PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of otherproteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC is involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory. These functions are achieved by PKC-mediated phosphorylation of other proteins.

PKC Isoform Specific Products:

PKC Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-132302A
    Hu7691 free base
    		Inhibitor
    Hu7691 free base is an orally active, selective Akt inhibitor with IC50s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. Hu7691 free base inhibits tumor growth and enables decrease of cutaneous toxicity in mice.
    Hu7691 free base
  • HY-13502B
    Mitoxantrone diacetate
    		Inhibitor
    Mitoxantrone diacetate is a potent topoisomerase II inhibitor. Mitoxantrone diacetate also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone diacetate induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone diacetate shows antitumor activity. Mitoxantrone diacetate also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.
    Mitoxantrone diacetate
  • HY-10341B
    Fasudil hydrochloride semihydrate
    		Inhibitor
    Fasudil (HA-1077; AT877) hydrochloride semihydrate is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil hydrochloride semihydrate is also a potent Ca2+ channel antagonist and vasodilator.
    Fasudil hydrochloride semihydrate
  • HY-W015546R
    β-N-methylamino-L-alanine hydrochloride (Standard)
    		Inhibitor
    Clenbuterol (Standard) is the analytical standard of Clenbuterol. This product is intended for research and analytical applications. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM. Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator.
    β-N-methylamino-L-alanine hydrochloride (Standard)
  • HY-RS11134
    PRKCI Human Pre-designed siRNA Set A
    		Inhibitor

    PRKCI Human Pre-designed siRNA Set A contains three designed siRNAs for PRKCI gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PRKCI Human Pre-designed siRNA Set A
  • HY-126376
    Iso-​H7 dihydrochloride
    		Inhibitor 99.06%
    Iso-​H7 dihydrochloride is an inhibitor of protein kinase with IC50 values of 22 and 34 μM to PKC and PKA respectively. Iso-H7 dihydrochloride has negative control of PKA on satellite cell myogenesis.
    Iso-​H7 dihydrochloride
  • HY-13772R
    Valrubicin (Standard)
    		Inhibitor
    Valrubicin (Standard) is the analytical standard of Valrubicin. This product is intended for research and analytical applications. Valrubicin is a chemotherapy agent, inhibits TPA-and PDBu-induced PKC activation with IC50s of 0.85 and 1.25 μM, respectively, and has antitumor and antiinflammatory activity.
    Valrubicin (Standard)
  • HY-147712
    PKC-IN-4
    		Inhibitor
    PKC-IN-4 (compound 7l) is a potent and orally active aPKC inhibitor with an IC50 of 0.52 µM. PKC-IN-4 inhibits TNF-α induced NF-κB activity in vitro. PKC-IN-4 blocks VEGF- and TNFα-induced permeability across the retinal vasculature.
    PKC-IN-4
  • HY-122858
    PKCiota-IN-2
    		Inhibitor
    PKCiota-IN-2 (Compound 49) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively.
    PKCiota-IN-2
  • HY-P10085
    PKC-ε translocation inhibitor peptide
    		Inhibitor
    PKC-ε translocation inhibitor peptide is a PKC-ε translocation inhibitor. PKC-ε translocation inhibitor peptide can regulate the rate of FcγR-mediated internalization of opsonized beads, has no effect of FcαR trafficking.
    PKC-ε translocation inhibitor peptide
  • HY-183252
    ICA-1S
    		Inhibitor
    ICA-1S is a specific PKC-ι inhibitor. ICA-1S can inhibit MAPK/JNK signaling pathway and downregulate the levels of c-Jun and TNF-α. ICA-1S inhibits the proliferation of breast cancer cells. ICA-1S induces apoptosis of breast cancer cells. ICA-1S can be used in breast cancer-related research.
    ICA-1S
  • HY-121828
    TX-1123
    		Inhibitor
    TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer.
    TX-1123
  • HY-131305
    HBDDE
    		Inhibitor 98.03%
    HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis.
    HBDDE
  • HY-N9097
    Niazirin
    		Inhibitor 99.9%
    Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced PKCζ activation and inhibits Nox4 protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis.
    Niazirin
  • HY-P1284A
    ZIP TFA
    		Inhibitor
    ZIP TFA is a selective peptide inhibitor of PKMζ. ZIP TFA injections can block the impairment in morphine conditioned place preference induced.
    ZIP TFA
  • HY-RS11139
    Prkcq Rat Pre-designed siRNA Set A
    		Inhibitor

    Prkcq Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkcq gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkcq Rat Pre-designed siRNA Set A
  • HY-130305A
    GSK-943949A
    		Inhibitor
    GSK-943949A is a PRK1 inhibitor with an IC50 of 40.0 nM. GSK-943949A is applicable to research related to prostate cancer.
    GSK-943949A
  • HY-129099AR
    N-Desmethyltamoxifen hydrochloride (Standard)
    		Inhibitor
    N-Desmethyltamoxifen (hydrochloride) (Standard) is the analytical standard of N-Desmethyltamoxifen (hydrochloride). This product is intended for research and analytical applications. N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].
    N-Desmethyltamoxifen hydrochloride (Standard)
  • HY-RS11127
    Prkce Rat Pre-designed siRNA Set A
    		Inhibitor

    Prkce Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkce gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkce Rat Pre-designed siRNA Set A
  • HY-RS11123
    Prkcd Mouse Pre-designed siRNA Set A
    		Inhibitor

    Prkcd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkcd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkcd Mouse Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
PKC Isoform Comparison

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