2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Quinone Reductase

Quinone Reductase

Quinone Reductase

Quinones, a class of organic compounds, are formally derived from aromatic compounds and are a subset of the quinoid family which also contains the quinone imines and the quinone methides. NQO1 (QR1, EC 1.6.99.2), also referred to as DT-diaphorase (formerly), nicotinamide quinone oxidoreductase 1, quinone reductase type 1, or menadione reductase, is a cytosolic flavoenzyme. Another member of the quinone oxidoreductases family is NQO2 (QR2, EC 1.10.99.2) which is also a FAD bound protein (25 kDa) and closely related to NQO1. In addition to NQO1 and NQO2 found in humans, an ancient NQO3 subfamily exists in eubacteria, NQO4 subfamily in fungi, and NQO5 subfamily in archaebacteria[1][2].

Quinone Reductase Related Products (58):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-176720
    NQO1 inducer 1
    		Inducer
    NQO1 inducer 1 (Compound 20) is a potent NQO1 inducer (CD=3 μM). NQO1 inducer 1 is a promising antioxidant that can be used for the research of redox-modulating.
    NQO1 inducer 1
  • HY-147795
    Nampt-IN-8
    		Substrate
    Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS.
    Nampt-IN-8
  • HY-141439
    TBE 31
    		Inducer
    TBE 31 is an orally active Keap1/Nrf2 pathway activator and NQO1 inducer with a Dm value of 1.1 nM for NQO1. TBE 31 binds to cysteine residues of Keap1, inhibits ubiquitination and degradation of Nrf2, thereby activating the expression of ARE-dependent genes. TBE 31 induces cytoprotective enzymes including NQO1 and GST isoforms, promotes Nrf2 accumulation, and upregulates Nrf2-regulated genes related to antioxidation and lipid metabolism. TBE 31 inhibits pro-inflammatory responses, formation of AFB1-DNA adducts, endoplasmic reticulum stress, cell apoptosis (apoptosis), hepatic fibrosis, oxidative stress, and the expression of ChREBP. TBE 31 reduces the number of tumors in a mouse model of ultraviolet-induced skin carcinogenesis. TBE 31 enhances nerve growth factor-induced neurite outgrowth. TBE 31 attenuates LPS-induced serum TNF-α levels and immobility time in mice. TBE 31 can be used in research related to liver cancer, skin cancer, inflammation-related depression, and non-alcoholic steatohepatitis.
    TBE 31
  • HY-180168
    NQO2 activator-1
    		Activator
    NQO2 activator-1 (Compound 1d) is a selective NQO2 activator with 20.89% increase of NQO2 activity at 10 μM. NQO2 activator-1 strongly inhibits NLRP3 inflammasome activation. NQO2 activator-1 can be used for the research of inflammation and immunology, such as rheumatoid arthritis.
    NQO2 activator-1
  • HY-170947
    Antitumor agent-195
    		Inhibitor
    Antitumor agent-195 (compound 16c) is a dual targeting agent of STAT3 and NQO1. Antitumor agent-195 significantly inhibits phosphorylation of STAT3 at Tyr705 at a concentration of 1 μM and effectively induce Apoptosis in MDAMB-231 and MDA-MB-468 breast cancer cells. Antitumor agent-195 as a NQO1 substrate strongly increases ROS generation and causes severe DNA damage in a dose-dependent manner. Antitumor agent-195 shows encouraging anti-tumor efficacy in the MDA-MB-231 xenograft model.
    Antitumor agent-195
  • HY-N15190
    Sesaminol
    		Activator
    Sesaminol is an orally active activator for Nrf2-ARE pathway, that promotes the the nuclear translocation of Nrf2 and enhances the NQO1 expression, thereby enhances the cell's defense against oxidative stress. Sesaminol inhibits 6-OHDA (HY-B1081)-induced ROS production and apoptosis in cell SH-SY5Y. Sesaminol exhibits neuroprotective efficacy against Rotenone (HY-B1756)-induced Parkinson's disease.
    Sesaminol
  • HY-125995
    NFE2L2 activator 3
    		Activator
    NFE2L2 activator 3 (Compound 3) is a NFE2L2/NRF2 activator. NFE2L2 activator 3 specifically activates the NAD(P)H:quinone oxidoreductase (NQO1) enzyme, with its EC50 < 1 nM. NFE2L2 activator 3 can be used for research on respiratory system diseases such as chronic obstructive pulmonary disease.
    NFE2L2 activator 3
  • HY-N15456
    Cryptolepinone
    		Activator
    Cryptolepinone is a quinone reductase activator with a CD (concentration required to double induction) value of 0.02 μg/mL and can be found in Sida acuta. In the mouse mammary organ culture assay, 10 μg/mL of Cryptolepinone inhibited 83.3% of the preneoplastic lesions induced by DMBA (HY-W011845). Cryptolepinone can be used in anti-cancer research.
    Cryptolepinone
  • HY-169842
    NSC 645827
    		Inhibitor
    NSC 645827 is an inhibitor for NAD(P)H: quinone oxidoreductase 1 (NQO1) with an IC50 of 0.7 μM.
    NSC 645827
  • HY-RS22982
    Nqo1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Nqo1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nqo1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Nqo1 Rat Pre-designed siRNA Set A
  • HY-108992R
    Deoxynyboquinone (Standard)
    		Inhibitor
    Deoxynyboquinone (Standard) is the analytical standard of Deoxynyboquinone (HY-108992). This product is intended for research and analytical applications. Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone Kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation.
    Deoxynyboquinone (Standard)
  • HY-RS16549
    Nqo1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Nqo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nqo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Nqo1 Mouse Pre-designed siRNA Set A
  • HY-103667R
    2-HBA (Standard)
    		Inducer
    2-HBA (Standard) is the analytical standard of 2-HBA (HY-103667). This product is intended for research and analytical applications. 2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
    2-HBA (Standard)
  • HY-121425
    Dunnione
    Dunnione (CompoundⅠ) is a pigment. Dunnione can be isolated from the leaves of Didymocarpus pedicellata.
    Dunnione
  • HY-N14947
    Pterulinic acid
    		Inhibitor
    Pterulinic acid is a coenzyme I: Coenzyme Q oxidoreductase inhibitor. he IC50 (μg/mL) L1210 and HL60 of Pterulinic acid to mammalian cell lines are 50 and 20 respectively. HeLaS3 25; BHK is 100.
    Pterulinic acid
  • HY-N7093R
    Furaneol (Standard)
    		Activator
    Furaneol (Standard) is the analytical standard of Furaneol. This product is intended for research and analytical applications. Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines.
    Furaneol (Standard)
  • HY-N14897
    Pterulone
    		Inhibitor
    Pterulone is a coenzyme I: Coenzyme Q oxidoreductase inhibitor found in fungus Pterula SP.82168.
    Pterulone
  • HY-147548
    Keap1-Nrf2-IN-10
    		Inhibitor
    Keap1-Nrf2-IN-10 (compound 15) is a potent NQO1 inducer. Keap1-Nrf2-IN-10 inhibits oxidative stress by decreasing the levels of MDA, ROS, NQO1 in the liver for gamma-irradiated mice. Keap1-Nrf2-IN-10 improves the survival of gamma-irradiated mice.
    Keap1-Nrf2-IN-10