Reactive Oxygen Species (ROS)
Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.
ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
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Reactive Oxygen Species (ROS) Inhibitors
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Reactive Oxygen Species (ROS) Agonists
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Reactive Oxygen Species (ROS) Antagonists
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Reactive Oxygen Species (ROS) MDM2 Inhibitor
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Reactive Oxygen Species (ROS) Controls
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Reactive Oxygen Species (ROS) Substrates
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Reactive Oxygen Species (ROS) Related Products (2850)
Related Products (2850)
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Antibodies (8)
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GNE-140 racemate (Standard)
0 ImagesCat. No.: HY-100742RCAS No.: 1802977-61-2GNE-140 racemate (Standard) is the analytical standard of GNE-140 racemate (HY-100742). This product is intended for research and analytical applications. GNE-140 racemate is a racemic mixture of (R)-GNE-140 (HY-100742A) and (S)-GNE-140 (HY-100742B), and also a tautomer of GNE-140 (HY-118241). GNE-140 racemate is an orally active lactate dehydrogenase inhibitor, with an IC50 of 3 nM against human LDHA and an IC50 of 5 nM against LDHB. GNE-140 racemate reduces the phosphorylation level and total protein expression of p38 MAPK, and inhibits EGF-induced AKT phosphorylation. GNE-140 racemate decreases lactate production, regulates glycolysis, the pentose phosphate pathway and nucleotide biosynthesis, increases extracellular pH, inhibits cell proliferation, migration and invasion, and induces caspase-3 activation and ROS accumulation. GNE-140 racemate can be used in research related to breast cancer, cystic fibrosis and pancreatic cancer.
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Antibacterial agent 308
0 ImagesCat. No.: HY-180240CAS No.: 3092564-74-1Antibacterial agent 308 (Compound A25) is an antibacterial agent. Antibacterial agent 308 selectively targets bacterial membranes by binding phosphatidylethanolamine, thereby disrupting membrane polarization, elevating intracellular ROS levels. Antibacterial agent 308 shows significant anti-biofilm activity against S. aureus. Antibacterial agent 308 demonstrates potent anti-MRSA activity.
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USF 2550A
0 ImagesCat. No.: HY-W450115CAS No.: 5192-62-1USF 2550A is a class of fungus-derived 2-pyran compound with DPPH free radical scavenging activity. USF 2550A binds to DPPH free radicals in organic solvents to form adducts, thereby achieving free radical scavenging; in acetate buffer, the formed adducts undergo degradation, and the degradation products can continuously scavenge free radicals. USF 2550A can be used in antioxidant-related research.
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S-Methyl-L-cysteine (Standard)
0 ImagesS-Methyl-L-cysteine (Standard) is the analytical standard of S-Methyl-L-cysteine. This product is intended for research and analytical applications. S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.
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Hydroxytyrosol acetate (Standard)
0 ImagesCat. No.: HY-N6043RCAS No.: 69039-02-7Hydroxytyrosol acetate (Standard) is the analytical standard of Hydroxytyrosol (HY-N0570). This product is intended for research and analytical applications. Hydroxytyrosol acetate is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol acetate not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol acetate effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol acetate significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol acetate has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields.
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Temoporfin (Standard)
0 ImagesCat. No.: HY-16488RCAS No.: 122341-38-2Synonyms: m-THPC (Standard); KW2345 (Standard)Temoporfin (Standard) is the analytical standard of Temoporfin. This product is intended for research and analytical applications. Temoporfin (m-THPC), a reduced porphyrin, is a potent second-generation photosensitizer. Temoporfin can be used in the research of photodynamic therapy (PDT) for head and neck cancers.
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Tanzawaic acid B
0 ImagesCat. No.: HY-N12914CAS No.: 169181-33-3Synonyms: (+)-Tanzawaic acid B; GS-1302-1; 10-Deoxytanzawaic acid ETanzawaic acid B ((+)-Tanzawaic acid B; GS-1302-1; 10-Deoxytanzawaic acid E) is a superoxide anion production inhibitor and can be isolated from Penicillium citrinum.
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Selaginellin
0 ImagesCat. No.: HY-N10083CAS No.: 941269-84-7Selaginellin is an inhibitor of Reactive Oxygen Species and an activator of SIRT1. Selaginellin protects endothelial cells against homocysteine-induced senescence by inhibitng reactive oxygen species and upregulating SIRT1 gene expression.
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Mutatochrome
0 ImagesMutatochrome (Citroxanthin) is a naturally occurring carotenoid pigment found in certain plants. Mutatochrome has antioxidant property to help protect cells from damage caused by free radicals. Mutatochrome can be used for anti-inflammatory and anticancer study.
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Antileishmanial agent-35
0 ImagesCat. No.: HY-178033CAS No.: 100611-91-4Antileishmanial agent-35 (Compound 6) is an antileishmanial agent with an IC50 of 0.29μM for promastigotes of Leishmania amazonensis. Antileishmanial agent-35 significantly decreases the mitochondrial membrane potential and ATP levels, and further increases the production of ROS by a blockage in the electron transport chain, where ubiquinone intervenes. Antileishmanial agent-35 can be used for cutaneous leishmaniases research.
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MRT68921 dihydrochloride (Standard)
0 ImagesMRT68921 (dihydrochloride) (Standard) is the analytical standard of MRT68921 (dihydrochloride) (HY-100006A). This product is intended for research and analytical applications. MRT68921 dihydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 dihydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 dihydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 dihydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 dihydrochloride can be used for the research of cancer, such as breast cancer.
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Pretilachlor (Standard)
0 ImagesCat. No.: HY-B2035RCAS No.: 51218-49-6Pretilachlor (Standard) is the analytical standard of Pretilachlor (HY-B2035). This product is intended for research and analytical applications. Pretilachlor is a chloroacetamide herbicide with biological activities including endocrine disruption, oxidative stress induction, apoptosis induction, and immunotoxicity. Pretilachlor exerts its effects by interfering with hormone metabolism, inducing oxidative stress, activating apoptotic pathways, and inhibiting immune functions. Pretilachlor upregulates the transcription of P53, Mdm2, and Bbc3, and increases the activities of Caspase3 and Caspase9; it upregulates the transcription of genes in the HPG/HPT axis and the activity of aromatase; it induces oxidative stress, elevates ROS levels, and upregulates CAT, SOD, and GPX. Pretilachlor downregulates the transcription of CXCL-C1C, IL-1β, and IL-8. Pretilachlor disrupts the normal physiological processes and embryonic development of fish, exhibiting significant toxicity. Pretilachlor can be used in studies related to weeding, environmental pollution, and behavioral toxicity in fish.
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Insecticidal agent 38
0 ImagesCat. No.: HY-187808CAS No.: 257880-89-0Insecticidal agent 38 is a AChE inhibitor and Insecticide, with an IC50 of 49.08 μg/mL against AChE. Insecticidal agent 38 inhibits the activities of SOD, Catalase and Glutathione-S-transferase. Insecticidal agent 38 induces intracellular ROS, lipofuscin and lipid accumulation, increases malondialdehyde levels, disrupts redox homeostasis and triggers oxidative damage. Insecticidal agent 38 inhibits the feeding and reproductive capabilities of the pine wood nematode (Bursaphelenchus xylophilus). Insecticidal agent 38 exhibits insecticidal activity against nematodes. Insecticidal agent 38 can be used in studies of plant-parasitic nematode infections.
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Laxogenin
0 ImagesLaxogenin ((25R)-3β-Hydroxy-5α-spirostan-6-one; 6-Oxotigogenin) is an orally active myostatin (myostatin) inhibitor. Laxogenin promotes myogenesis and enhances the formation and maturation of myotubes. Laxogenin downregulates ROS. When added to the culture medium for cultured meat production, Laxogenin improves the texture, quality and nutritional value of cultured meat. Laxogenin reduces the average number of tumors in a two-stage mouse lung carcinogenesis model. Laxogenin can be used in research related to myogenesis and lung cancer.
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Antibacterial agent 307 hydrochloride
0 ImagesCat. No.: HY-180125AAntibacterial agent 307 hydrochloride is an antibacterial agent. Antibacterial agent 307 hydrochloride shows MICs of 1-4 μg/mL against Gram-positive bacteria, moderate activity against Gram-negative bacteria, low hemolytic toxicity, and excellent plasma stability. Antibacterial agent 307 hydrochloride compromises bacterial membrane integrity via increased permeability and depolarization, induces endogenous ROS accumulation, causes cytoplasmic protein and nucleic acid leakage, and drives rapid bacterial cell death. Antibacterial agent 307 hydrochloride can be used for the research of bacterial infection.
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SKI II hydrochloride
0 ImagesCat. No.: HY-112364CAS No.: 1177741-83-1SKI-II hydrochloride is an orally active dual-target inhibitor of SphK1/2 and DES1, with Ki values of 16 µM and 0.3 µM against SphK1 and DES1, respectively. SKI-II hydrochloride activates the PERK-Nrf2 antioxidant pathway by stabilizing Nrf2, and synergizes with Temozolomide (HY-17364) to induce oxidative/endoplasmic reticulum stress and cancer cell death under hypoxic conditions. SKI-II hydrochloride inhibits SphK activity, promotes ceramide accumulation and apoptosis, and synergizes with Cisplatin (HY-17394) to reverse drug resistance via the ras/MAPK pathway in vivo. SKI-II hydrochloride reduces measles virus replication by inhibiting mTORC1 activity. SKI-II hydrochloride binds to VCP to induce M1 polarization, enhances host tolerance to Staphylococcus aureus infection, and exerts radioprotective effects through Nrf2 activation and accelerated DNA repair. SKI-II hydrochloride can be used in research related to glioblastoma, acute myeloid leukemia, gastric cancer, measles virus infection, Staphylococcus aureus infection, and acute radiation syndrome.
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Rufigallol
0 ImagesRufigallol is one of the earliest systems reported to form columnar mesophases. Rufigallol is also an oxidant agent. Rufigallol acts in a pro-oxidant fashion to produce oxygen radicals inside parasitized erythrocytes. Rufigallol has vitamin K activity and antimalarial activity.
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Phillygenin-O-β-glucosaminide
0 ImagesCat. No.: HY-189489Phillygenin-O-β-glucosaminide is an orally active Nrf2 inducer and NF-κB inhibitor that inhibits osteoclast differentiation and ROS production by promoting Nrf2 nuclear translocation, suppressing NF-κB and JNK phosphorylation, and downregulating NFATc1, c-Fos, MMP9, and CTSK expression. Phillygenin-O-β-glucosaminide can be used for research on osteoarthritis.
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Tempol (Standard)
0 ImagesCat. No.: HY-100561RCAS No.: 2226-96-2Synonyms: 4-Hydroxy-TEMPO (Standard); MBM-02 (Standard)Tempol (Standard) is the analytical standard of Tempol. This product is intended for research and analytical applications. Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS).
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Pyropheophorbide-a (Standard)
0 ImagesCat. No.: HY-128973RCAS No.: 24533-72-0Pyropheophorbide-a (Standard) is the analytical standard of Pyropheophorbide-a. This product is intended for research and analytical applications. Pyropheophorbide-a (Ppa) is a photosensitizer used in photodynamic therapy (PDT) for tumors. Pyropheophorbide-a exhibits phototoxic effects on tumor cells, such as cervical cancer cells, and also has anti-lipogenesis activity. Pyropheophorbide-a shows potential for research in the fields of cancer and age-related macular degeneration (AMD). Pyropheophorbide-a derivatives also demonstrate inhibitory activity against tumor cells.
