Art. -Nr.: HY-N0231

Bavachalcone

(Synonyms: Broussochalcone B)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Bavachalcone is a potent inducer of apoptosis. Bavachalcone exerts anticancer activity by promoting autophagy and apoptosis in HepG2 cells. Bavachalcone acts as an anti-neuroinflammatory and antidepressant through the NF-κB pathway. Bavachalcone inhibits osteoclasts by interfering with ERK and Akt signaling pathways and the expression of c-Fos and NFATc1. Bavachalcone exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.

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Reinheit: 99.90%
CAS. Nr.: 28448-85-3
Formel: C₂₀H₂₀O₄
Molecular Weight:324.37

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Bavachalcone Chemical Structure

CAS. Nr.: 28448-85-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

Alle NF-κB Isoform-spezifische Produkte anzeigen :

Alle Akt Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>10 μM Compound: 9	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25710081]
HUVEC	IC₅₀	39.73 μM Compound: 1a	Toxicity against HUVEC incubated for 48 hrs by MTT assay Toxicity against HUVEC incubated for 48 hrs by MTT assay	[PMID: 25590864]
K562	IC₅₀	>10 μM Compound: 9	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 25710081]
K562	IC₅₀	2.77 μM Compound: 1a	Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay	[PMID: 25590864]

In Vitro

Bavachalcone (5 μg/mL; 1-48 h) inhibits osteoclasts by interfering with ERK and Akt signaling pathways and the expression of c-Fos and NFATc1^[1].
. Bavachalcone (0-100 μg/mL; 24h) is toxic to HepG2 cells with IC₅₀ of 20 μg/mL^[3]. Bavachalcone (20 μg/mL; 24 h) induces apoptosis in HepG2^[3].
Bavachalcone (0-20 μg/mL; 24 h) induces cell cycle arrest in HepG2 cells^[3].
Bavachalcone (0-20 μg/mL; 24 h) induces autophagy through Akt-mTOR signaling pathway^[3].
Bavachalcone (5-10 μM; 2 h) inhibits the activation of NF-κB pathway in LPS (HY-D1056)-induced BV2 cells, upregulated the expression of A20 and TAX1BP1, and enhanced their interaction^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

RANKL treated bone marrow-derived macrophages
Concentration:

5 μg/mL
Incubation Time:

0, 12, 24 and 48 h;
1 h
Result:

Reduced the levels of c-Fos and NFATc1.
Reduced the phosphorylation levels of ERK and Akt.

Western Blot Analysis^[3]

Cell Line:

HepG2 cell
Concentration:

20 μg/mL
Incubation Time:

24 h
Result:

Significantly increased the levels of caspase-3.

Western Blot Analysis^[3]

Cell Line:

HepG2 cell
Concentration:

0, 5, 10 and 20 μg/mL
Incubation Time:

24 h
Result:

Decreased the levels of early cell cycle regulatory proteins cdk4 and cdk2.
Increased the levels of p21 and p27.
Inhibited the phosphorylation and expression of both Akt and mTOR.

Western Blot Analysis^[4]

Cell Line:

LPS (HY-D1056) treated BV2 cells
Concentration:

5 μM and 10 μM
Incubation Time:

2 h
Result:

Significantly decreased the expression of TRAF6 and phosphorylation of P65 and IκBα.
Increased the expression of A20 and TAX1BP1

In Vivo

Bavachalcone (30-60 mg/kg; Intraperitoneal injection; 4 days) exerts anti-neuroinflammatory and anti-depressive effects in LPS (HY-D1056) -induced mouse models^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LPS (HY-D1056) treated male C57BL/6 mice (8 weeks, 20 ± 2 g)
Dosage:

30 mg/kg and 60 mg/kg
Administration:

Intraperitoneal injection (i.p.); 4 days
Result:

Attenuated LPS-induced depression-like behaviors in mice.
Inhibited LPS-induced activation of microglia in the brain of mice.
Inhibited LPS-induced NF-κB pathway activation and upregulated the expression of A20 and TAX1BP1 in the cortex of mice.
Weakened the production of TNF-α and IL-6 in the cortex of mice.

Chemical Information

CAS. Nr. 28448-85-3
Appearance Solid
Molecular Weight 324.37
Formel C₂₀H₂₀O₄
Color Yellow to orange
SMILES

O=C(C1=CC(C/C=C(C)\C)=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2
Synonyms

Broussochalcone B
Structure Classification
- Flavonoids
- Chalcones
- Phenols
- Polyphenols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (2)

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Chem Biol Interact

Bavachinin, a main compound of Psoraleae Fructus, facilitates GSDMD-mediated pyroptosis and causes hepatotoxicity in mice. [Abstract]

2024 Jul 3:111133. PMID: 38969277
BMC Cancer

4'-O-Methylbroussochalcone B as a novel tubulin polymerization inhibitor suppressed the proliferation and migration of acute myeloid leukaemia cells. [Abstract]

2021 Jan 22;21(1):91. PMID: 33482772

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 34 mg/mL (104.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0829 mL

15.4145 mL

30.8290 mL

5 mM

0.6166 mL

3.0829 mL

6.1658 mL

10 mM

0.3083 mL

1.5414 mL

3.0829 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Park CK, et al. Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL. Biochem Pharmacol. 2008 Jun 1;75(11):2175-82. [Content Brief]

[2]. Choi YH, et al. In vitro BACE-1 inhibitory phenolic components from the seeds of Psoralea corylifolia. Planta Med. 2008 Sep;74(11):1405-8. [Content Brief]

[3]. Song HS, et al. Bavachalcone from Cullen corylifolium induces apoptosis and autophagy in HepG2 cells. Phytomedicine. 2018 Feb 1;40:37-47. [Content Brief]

[4]. Wu X, et al. Upregulation of A20 and TAX1BP1 contributes to the anti-neuroinflammatory and antidepressant effects of bavachalcone. Int Immunopharmacol. 2023 Sep;122:110552. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.0829 mL	15.4145 mL	30.8290 mL	77.0725 mL
	5 mM	0.6166 mL	3.0829 mL	6.1658 mL	15.4145 mL
	10 mM	0.3083 mL	1.5414 mL	3.0829 mL	7.7072 mL
	15 mM	0.2055 mL	1.0276 mL	2.0553 mL	5.1382 mL
	20 mM	0.1541 mL	0.7707 mL	1.5414 mL	3.8536 mL
	25 mM	0.1233 mL	0.6166 mL	1.2332 mL	3.0829 mL
	30 mM	0.1028 mL	0.5138 mL	1.0276 mL	2.5691 mL
	40 mM	0.0771 mL	0.3854 mL	0.7707 mL	1.9268 mL
	50 mM	0.0617 mL	0.3083 mL	0.6166 mL	1.5414 mL
	60 mM	0.0514 mL	0.2569 mL	0.5138 mL	1.2845 mL
	80 mM	0.0385 mL	0.1927 mL	0.3854 mL	0.9634 mL
	100 mM	0.0308 mL	0.1541 mL	0.3083 mL	0.7707 mL

Keywords

Bavachalcone

2 Cited Publications

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Bavachalcone

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Publications Citing Use of MedChemExpress (MCE) Bavachalcone

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Alle NF-κB Isoform-spezifische Produkte anzeigen

Alle Akt Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit