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Art. -Nr.: HY-134008

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Protoapigenone

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Protoapigenone is an antineoplastic agent isolated from ferns. Protoapigenone has significant inhibitory activity against Hep G2, Hep 3B, MCF-7, A549 and MDAMB-231, with IC₅₀s values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL respectively.

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Reinheit: 99.84%
CAS. Nr.: 862884-32-0
Formel: C₁₅H₁₀O₆
Molecular Weight:286.24

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Protoapigenone Chemical Structure

CAS. Nr.: 862884-32-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Caspase Isoform-spezifische Produkte anzeigen :

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	13.85 μM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric method Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric method	[PMID: 17622129]
HEK293	IC₅₀	6.79 μM Compound: 1	Cytotoxicity against human HEK293 cells assessed as cell proliferation after 24 hrs by MTT assay Cytotoxicity against human HEK293 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
Hep 3B2	IC₅₀	2.27 μM Compound: 1	Cytotoxicity against human Hep3B cells after 72 hrs by MTT colorimetric method Cytotoxicity against human Hep3B cells after 72 hrs by MTT colorimetric method	[PMID: 17622129]
HepG2	IC₅₀	7.77 μM Compound: 1	Antitumor activity against human HepG2 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human HepG2 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
HepG2	IC₅₀	8.11 μM Compound: 1	Cytotoxicity against human HepG2 cells after 72 hrs by MTT colorimetric method Cytotoxicity against human HepG2 cells after 72 hrs by MTT colorimetric method	[PMID: 17622129]
MCF7	IC₅₀	3.74 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by MTT colorimetric method Cytotoxicity against human MCF7 cells after 72 hrs by MTT colorimetric method	[PMID: 17622129]
MCF7	IC₅₀	5.5 μM Compound: 1	Antitumor activity against human MCF7 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human MCF7 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
MDA-MB-231	IC₅₀	1.43 μM Compound: 1	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT colorimetric method Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT colorimetric method	[PMID: 17622129]
MDA-MB-231	IC₅₀	1.7 μM Compound: 1	Antitumor activity against human MDA-MB-231 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human MDA-MB-231 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
PANC-1	IC₅₀	22.09 μM Compound: 1	Antitumor activity against human PANC1 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human PANC1 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
PBMC	IC₅₀	8.11 μM Compound: 1	Cytotoxicity against human PBMC assessed as cell proliferation after 24 hrs by MTT assay Cytotoxicity against human PBMC assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
PC-3	IC₅₀	6.13 μM Compound: 1	Antitumor activity against human PC3 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human PC3 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
RPMI-8226	IC₅₀	3.93 μM Compound: 1	Antitumor activity against human RPMI8226 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human RPMI8226 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
SK-OV-3	IC₅₀	0.71 μM Compound: 1	Antitumor activity against human SKOV3 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human SKOV3 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
U-266	IC₅₀	7.66 μM Compound: 1	Antitumor activity against human U266 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human U266 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]

Chemical Information

CAS. Nr. 862884-32-0
Appearance Solid
Molecular Weight 286.24
Formel C₁₅H₁₀O₆
Color White to light yellow
SMILES

OC1=C2C(OC(C3(O)C=CC(C=C3)=O)=CC2=O)=CC(O)=C1
Structure Classification
- Flavonoids
- Flavones
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lin A S, et al. New cytotoxic flavonoids from Thelypteris torresiana[J]. Planta medica, 2005, 71(09): 867-870.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
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Chemical Information
Reinheit & Dokumentation
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Protoapigenone

Alle Caspase Isoform-spezifische Produkte anzeigen

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Protoapigenone Related Classifications

HY-134008 Related Classifications