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Art. -Nr.: HY-117688

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WJ35435

WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that causes DNA damage associated with a low DNA repair capability and induces cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer.

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CAS. Nr.: 1620054-84-3
Formel: C₂₀H₂₁N₃O₃
Molecular Weight:351.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

WJ35435 Chemical Structure

CAS. Nr.: 1620054-84-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

Alle HDAC Isoform-spezifische Produkte anzeigen :

Alle Topoisomerase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	0.16 μM Compound: 41; WJ36435	Inhibition of colony formation in human DU-145 cells incubated for 10 days by crystal violet method Inhibition of colony formation in human DU-145 cells incubated for 10 days by crystal violet method	[PMID: 33143937]
DU-145	IC₅₀	0.33 nM Compound: 15; WJ35435	Antiproliferative activity against human DU-145 cells incubated for 48 hrs by Sulforhodamine B staining method Antiproliferative activity against human DU-145 cells incubated for 48 hrs by Sulforhodamine B staining method	[PMID: 33077264]
PC-3	IC₅₀	0.31 μM Compound: 41; WJ36435	Inhibition of colony formation in human PC-3 cells incubated for 10 days by crystal violet method Inhibition of colony formation in human PC-3 cells incubated for 10 days by crystal violet method	[PMID: 33143937]
PC-3	IC₅₀	0.39 nM Compound: 15; WJ35435	Antiproliferative activity against human PC-3 cells incubated for 48 hrs by Sulforhodamine B staining method Antiproliferative activity against human PC-3 cells incubated for 48 hrs by Sulforhodamine B staining method	[PMID: 33077264]

Chemical Information

CAS. Nr. 1620054-84-3
Molecular Weight 351.40
Formel C₂₀H₂₁N₃O₃
SMILES

O=C(C1=CC=CC2=CC3=C(N=C21)C=CC=C3)NCCCCCC(NO)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yu C C, et al. A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I[J]. Biochemical pharmacology, 2014, 90(3): 320-330. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
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WJ35435

Alle HDAC Isoform-spezifische Produkte anzeigen

Alle Topoisomerase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

Cellular Effect

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Bioz

Keywords

Your Recently Viewed Products

WJ35435

Alle HDAC Isoform-spezifische Produkte anzeigen

Alle Topoisomerase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

Cellular Effect

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

WJ35435 Related Classifications

HY-117688 Related Classifications

Bioz

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