HDAC1-IN-11
HDAC1-IN-11 (Compound 6) is a HDAC1 inhibitor with an IC50 of 106.6 nM. HDAC1-IN-11 inhibits the expression of Sp1 and RAD51, thereby inducing Caspase-dependent apoptosis. HDAC1-IN-11 has antitumor activity and sensitizes Etoposide (HY-13629) and Gemcitabine (HY-17026), promoting synergistic death of NSCLC cells through the inhibition of homologous recombination and non-homologous end joining (NHEJ) pathways involved in DNA DSB repair. HDAC1-IN-11 can be used for chemotherapy of cancers like NSCLC research.
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- Formule: C30H26N4O3
- Masse moléculaire:490.55
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
HDAC1 106.6 nM (IC50) |
HDAC6 2095 nM (IC50) |
Caspase-9 |
Caspase-3 |
Caspase-7 |
Chemical Information
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Masse moléculaire 490.55
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Formule C30H26N4O3
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SMILES
NC1=CC=CC=C1NC(C2=CC=C(C=C2)CN3C(N(C(C4=CC=CC=C43)=O)CCC5=CC=CC=C5)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC1-IN-11 Related Classifications
HY-178021 Related Classifications
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