DY-9760e
DY-9760e is a calmodulin (CaM) inhibitor. DY-9760e selectively inhibits the activity of various calmodulin-dependent enzymes by antagonizing the Ca²⁺/CaM complex, exhibiting the strongest inhibitory activity against nNOS, CaM kinase II, and calcineurin (Ki: 0.9, 1.4, and 2.0 μM, respectively). DY-9760e inhibits excessive nitric oxide production and protein tyrosine nitration, as well as the activation of calpain and caspase-3. DY-9760e reduces infarct size, improves cardiac function, and inhibits oxidative stress and cell death. DY-9760e can be used in research on the treatment of myocardial infarction, cerebral ischemia, and other diseases.
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- CAS. Nr.: 179185-73-0
- Formel: C26H31ClN6O2.2ClH.7/2H2O
- Molecular Weight:630.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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nNOS 0.9 nM (Ki) |
CaMK II 1.4 nM (Ki) |
Caspase 3 |
Chemical Information
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CAS. Nr. 179185-73-0
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Molecular Weight 630.50
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Formel C26H31ClN6O2.2ClH.7/2H2O
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SMILES
ClC1=CC=CC(N2CCN(CC2)CCC3=NN(CC4=CN=CN4)C5=C3C=C(OC)C(OC)=C5)=C1C.Cl.[7/2H2O].Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
DY-9760e Related Classifications
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