ARL6IP1 - ADP ribosylation factor like GTPase 6 interacting protein 1 Gene
Also Known as AIP1; ARMER; SPG61; ARL6IP
Species: Homo sapiens
About ARL6IP1
This gene has 8 transcripts (splice variants), 219 orthologues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 151.5), adrenal (RPKM 96.4) and 25 other tissues.
Summary
This gene belongs to the ARL6ip family and encodes a transmembrane protein that is predominantly localized to intracytoplasmic membranes. It is highly expressed in early myeloid progenitor cells and thought to be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Mutations in this gene are associated with spastic paraplegia 61 (SPG61). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
ARL6IP1 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001313858.1 | NP_001300787.1 | ADP-ribosylation factor-like protein 6-interacting protein 1 isoform 2 |
| NM_015161.3 | NP_055976.1 | ADP-ribosylation factor-like protein 6-interacting protein 1 isoform 1 |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| Biological Process GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| involved in endoplasmic reticulum tubular network formation |
IDA
IDA: Inferred from direct assay
|
24262037 | GOA |
| involved in endoplasmic reticulum tubular network membrane organization |
IDA
IDA: Inferred from direct assay
|
24262037 | GOA |
| involved in negative regulation of apoptotic process |
IDA
IDA: Inferred from direct assay
|
12754298 | GOA |
| involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
IDA
IDA: Inferred from direct assay
|
12754298 | GOA |
| involved in regulation of endoplasmic reticulum tubular network organization |
IMP
IMP: Inferred from mutant phenotype
|
24262037 | GOA |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| located in endoplasmic reticulum membrane |
IDA
IDA: Inferred from direct assay
|
12754298 | GOA |
| is active in endoplasmic reticulum tubular network |
IDA
IDA: Inferred from direct assay
|
35346366 | GOA |
ARL6IP1 Protein Structure
Reticulon: Reticulon (34 - 193)
- 0
- 100
- 203 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ADP-ribosylation factor-like protein 6-interacting protein 1 |
|
ARL6IP1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
ARL6IP1 | Q15041 | SUCLA2 | Homo sapiens | E5KS60 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | RETREG3 | Homo sapiens | Q86VR2 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | RETREG3 | Homo sapiens | Q86VR2 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | RETREG3 | Homo sapiens | Q86VR2 | 29892012 | |
|
Intra
|
ARL6IP1 | Q15041 | RETREG3 | Homo sapiens | Q86VR2 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | RETREG3 | Homo sapiens | Q86VR2 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | PBX3 | Homo sapiens | Q5JS98 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX10 | Homo sapiens | Q8N5Z3 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX10 | Homo sapiens | Q8N5Z3 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | TMEM248 | Homo sapiens | Q9NWD8 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | TMEM248 | Homo sapiens | Q9NWD8 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | TMEM248 | Homo sapiens | Q9NWD8 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | NDRG4 | Homo sapiens | Q9ULP0 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX11 | Homo sapiens | Q9Y5W9 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX11 | Homo sapiens | Q9Y5W9 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX11 | Homo sapiens | Q9Y5W9 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX10 | Homo sapiens | Q9Y5X0 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX10 | Homo sapiens | Q9Y5X0 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX10 | Homo sapiens | Q9Y5X0 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | TARS2 | Homo sapiens | Q9BW92 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | TFAM | Homo sapiens | Q00059 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | TFAM | Homo sapiens | Q00059 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | VMA21 | Homo sapiens | Q3ZAQ7 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | VMA21 | Homo sapiens | Q3ZAQ7 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | VMA21 | Homo sapiens | Q3ZAQ7 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | CERT1 | Homo sapiens | Q9Y5P4-2 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | TMED8 | Homo sapiens | Q6PL24 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | GPR151 | Homo sapiens | Q8TDV0 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | GPR151 | Homo sapiens | Q8TDV0 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | GPR151 | Homo sapiens | Q8TDV0 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | NDRG4 | Homo sapiens | Q9ULP0-2 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | MIEF2 | Homo sapiens | Q96C03-3 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | TMEM258 | Homo sapiens | P61165 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | TMEM258 | Homo sapiens | P61165 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SHISA5 | Homo sapiens | Q8N114-3 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SHISA5 | Homo sapiens | Q8N114-3 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SHISA5 | Homo sapiens | Q8N114-3 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | REEP6 | Homo sapiens | Q96HR9-2 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | REEP6 | Homo sapiens | Q96HR9-2 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | REEP6 | Homo sapiens | Q96HR9-2 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | STARD4 | Homo sapiens | Q96DR4 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX8 | Homo sapiens | Q9Y5X2 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX12 | Homo sapiens | Q9UMY4 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX12 | Homo sapiens | Q9UMY4 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | HSD17B13 | Homo sapiens | Q7Z5P4 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | HSD17B13 | Homo sapiens | Q7Z5P4 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | HSD17B13 | Homo sapiens | Q7Z5P4 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | C19orf18 | Homo sapiens | Q8NEA5 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | C19orf18 | Homo sapiens | Q8NEA5 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | C19orf18 | Homo sapiens | Q8NEA5 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX12 | Homo sapiens | Q9UMY4-1 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SUCLA2 | Homo sapiens | Q9P2R7 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | GOLPH3 | Homo sapiens | Q9H4A6 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | MCEMP1 | Homo sapiens | Q8IX19 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | MCEMP1 | Homo sapiens | Q8IX19 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | MCEMP1 | Homo sapiens | Q8IX19 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX1 | Homo sapiens | Q13596 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX1 | Homo sapiens | Q13596 | 21516116 | |
|
Intra
|
ARL6IP1 | Q15041 | ZFYVE21 | Homo sapiens | Q9BQ24 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | EHD3 | Homo sapiens | Q9NZN3 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | EHD3 | Homo sapiens | Q9NZN3 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | EHD3 | Homo sapiens | Q9NZN3 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | ACSF2 | Homo sapiens | Q96CM8 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | ACSF2 | Homo sapiens | Q96CM8 | 21516116 | |
|
Intra
|
ARL6IP1 | Q15041 | ACSF2 | Homo sapiens | Q96CM8 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | ACSF2 | Homo sapiens | Q96CM8 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | ACSF2 | Homo sapiens | Q96CM8 | 31515488 | |
|
Intra
|
ARL6IP1 | Q15041 | ACSF2 | Homo sapiens | Q96CM8 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | RNF5 | Homo sapiens | Q99942 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | RNF5 | Homo sapiens | Q99942 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | RNF5 | Homo sapiens | Q99942 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SHMT2 | Homo sapiens | P34897 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | MFSD14B | Homo sapiens | Q5SR56 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | MFSD14B | Homo sapiens | Q5SR56 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | MFSD14B | Homo sapiens | Q5SR56 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | MFSD5 | Homo sapiens | Q6N075 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | MFSD5 | Homo sapiens | Q6N075 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | MFSD5 | Homo sapiens | Q6N075 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | NAPB | Homo sapiens | Q9H115 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | NAPB | Homo sapiens | Q9H115 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | EMP1 | Homo sapiens | P54849 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | EMP1 | Homo sapiens | P54849 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | DIABLO | Homo sapiens | Q9NR28 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | DIABLO | Homo sapiens | Q9NR28 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | DIABLO | Homo sapiens | Q9NR28 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | DIABLO | Homo sapiens | Q9NR28 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | MYG1 | Homo sapiens | Q9HB07 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | MYG1 | Homo sapiens | Q9HB07 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | MYG1 | Homo sapiens | Q9HB07 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | CERT1 | Homo sapiens | Q9Y5P4 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SENP2 | Homo sapiens | Q9HC62 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SENP2 | Homo sapiens | Q9HC62 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | RTN4 | Homo sapiens | Q9NQC3 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | RTN4 | Homo sapiens | Q9NQC3 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | PAM16 | Homo sapiens | Q9Y3D7 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | MGST3 | Homo sapiens | O14880 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | MGST3 | Homo sapiens | O14880 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX4 | Homo sapiens | O95219 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX4 | Homo sapiens | O95219 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX4 | Homo sapiens | O95219 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX15 | Homo sapiens | Q9NRS6 | 31515488 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX15 | Homo sapiens | Q9NRS6 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SNX3 | Homo sapiens | O60493 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | GORASP2 | Homo sapiens | Q9H8Y8 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | GORASP2 | Homo sapiens | Q9H8Y8 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | GORASP2 | Homo sapiens | Q9H8Y8 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | GORASP2 | Homo sapiens | Q9H8Y8 | 29892012 | |
|
Intra
|
ARL6IP1 | Q15041 | CERT1 | Homo sapiens | Q9Y5P4 | 29892012 | |
|
Intra
|
ARL6IP1 | Q15041 | CERT1 | Homo sapiens | Q9Y5P4 | 31515488 | |
|
Intra
|
ARL6IP1 | Q15041 | NTAQ1 | Homo sapiens | Q96HA8 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SPG21 | Homo sapiens | Q9NZD8 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | SPG21 | Homo sapiens | Q9NZD8 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | SPG21 | Homo sapiens | Q9NZD8 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | RAB33A | Homo sapiens | Q14088 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | RAB33A | Homo sapiens | Q14088 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | INPP5K | Homo sapiens | Q9BT40 | 29892012 | |
|
Intra
|
ARL6IP1 | Q15041 | INPP5K | Homo sapiens | Q9BT40 | 16189514 | |
|
Intra
|
ARL6IP1 | Q15041 | INPP5K | Homo sapiens | Q9BT40 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | YIPF4 | Homo sapiens | Q9BSR8 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | YIPF4 | Homo sapiens | Q9BSR8 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | YIPF4 | Homo sapiens | Q9BSR8 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | MTERF3 | Homo sapiens | Q96E29 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
ARL6IP1 | Q15041 | GAD2 | Homo sapiens | Q05329 | 25416956 | |
|
Intra
|
ARL6IP1 | Q15041 | WDFY2 | Homo sapiens | Q96P53 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Spastic Paraplegia 61, Autosomal Recessive |
|
|
| Paraplegia |
|
|
| Spastic Paraplegia 57, Autosomal Recessive |
|
|
| Microcephaly, Seizures, And Developmental Delay |
|
|
| Spastic Paraplegia 73, Autosomal Dominant |
|
|
| Ayme-Gripp Syndrome |
|
|
| Spastic Paraplegia 43, Autosomal Recessive |
|
|
| Pettigrew Syndrome |
|
|
| Motor Neuron Disease |
|
|
| Hereditary Spastic Paraplegia |
|
|
| Spastic Ataxia |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | ARL6IP1 | RGD | RGD:735205 |
| Mus musculus | ARL6IP1 | MGD | MGI:1858943 |
| Bos taurus | ARL6IP1 | VGNC | VGNC:26150 |
| Others | ARL6IP1 | NCBI |