Grp94-IN-3
Grp94-IN-3 (Compound 47) is a selective ATP competitive inhibitor of Grp94, with a Kd value of 76 nM. Grp94-IN-3 has a much lower affinity for Hsp90α, with a Kd value of 9.17 μM. Grp94-IN-3 induces the degradation of integrin α2 (Integrin α2) in MDA-MB-231 cells and reduces the intracellular accumulation of mutant cardiac proteins in human trabecular meshwork cells. Grp94-IN-3 can be used for the study of metastatic cancer and open-angle glaucoma.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C22H24ClN3O4
- Molecular Weight:429.90
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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GRP94 76 nM (Kd) |
HSP90α 9.17 μM (Kd) |
Chemical Information
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Molecular Weight 429.90
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Formel C22H24ClN3O4
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SMILES
O=C(OC)C(C(O)=CC(O)=C1Cl)=C1CCN2N=NC=C2CC3=CC=CC=C3CCC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Grp94-IN-3 Related Classifications
HY-180195 Related Classifications
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