Cimpuciclib
Cimpuciclib is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity.
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- CAS No.: 2202767-78-8
- Formule: C30H35FN8O
- Masse moléculaire:542.65
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CDK4 0.49 nM (IC50) |
CDK6 9.56 nM (IC50) |
Cimpuciclib (example 63, 141.2 nM, 6 days) inhibits proliferation in colo205 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Colo205 cells
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Concentration:0-500 nM approximately
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Incubation Time:6 days
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Result:Inhibited cell proliferation with an IC50 value of 141.2 nM.
Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) shows slow metabolic rate and maintains high concentration in the plasma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Colo205 tumor-bearing mice[1]
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Dosage:50 mg/kg, twice a week
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Administration:Oral gavage
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Result:Inhibited tumor growth by 93.63%.
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Animal Model:Rats, colo205 tumor-bearing mice[1]
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Dosage:5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
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Administration:Oral administration
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Result:Pharmacokinetic profile of Cimpuciclib (example 63).
dose (mg/kg) Cmax (ng/mL) Tmax (h) AUC0-24 (ng/mL•h) t1/2 (h) 5 mg/kg (rats) 559.7 6 5414 2.4 50 mg/kg (mice) 7960 1 136782 14.8
Chemical Information
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CAS No. 2202767-78-8
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Masse moléculaire 542.65
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Formule C30H35FN8O
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SMILES
O=C(N1CCC(CC1)NC2CC2)C3=CC=C(NC4=NC(C5=CC6=C(N=C(C)N6C(C)C)C=C5)=C(F)C=N4)N=C3C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cimpuciclib Related Classifications
HY-112243 Related Classifications
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