Dapsone-d8
Based on 1 Customer Validation
Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities. Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases.
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- Pureté: 99.82%
- CAS No.: 557794-38-4
- Formule: C12H4D8N2O2S
- Masse moléculaire:256.35
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Dapsone (0.06 mM; 30 min) suppresses intra- and extracellular production of superoxide (O2-) and elastase release triggered by N-Formyl-Met-Leu-Phe (HY-P0224) (1 μM) and physiological agonist C5a (100 nM), but not by Phorbol 12-myristate 13-acetate (HY-18739) (100 nM)[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Scopolamine-induced memory impairment model in mice[6]
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Dosage:0.1, 0.3, 1, 5, and 10 mg/kg; 1 mg/kg for Scopolamine
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Administration:Intraperitoneal injection; single dose
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Result:Improved memory acquisition.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 557794-38-4
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Unlabeled Cas 80-08-0
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Appearance Solid
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Masse moléculaire 256.35
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Formule C12H4D8N2O2S
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Color White to off-white
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SMILES
NC1=C(C([2H])=C(C([2H])=C1[2H])S(C2=C(C([2H])=C(C([2H])=C2[2H])N)[2H])(=O)=O)[2H]
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Synonyms
4,4′-Diaminodiphenyl sulfone-d8; DDS-d8
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 250 mg/mL (975.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol [Content Brief]
[2]. Dapsone. Drug.com
[3]. D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9. [Content Brief]
[4]. Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11(11):607. [Content Brief]
[5]. Wozel G, et al. Dapsone in dermatology and beyond. Arch Dermatol Res. 2014 Mar;306(2):103-24. [Content Brief]
[6]. Noroozi N, et al. Protective Effects of Dapsone on Scopolamine-Induced Memory Impairment in Mice: Involvement of Nitric Oxide Pathway. Dement Geriatr Cogn Dis Extra. 2022 Mar 24;12(1):43-50. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9009 mL | 19.5046 mL | 39.0092 mL | 97.5229 mL |
| 5 mM | 0.7802 mL | 3.9009 mL | 7.8018 mL | 19.5046 mL | |
| 10 mM | 0.3901 mL | 1.9505 mL | 3.9009 mL | 9.7523 mL | |
| 15 mM | 0.2601 mL | 1.3003 mL | 2.6006 mL | 6.5015 mL | |
| 20 mM | 0.1950 mL | 0.9752 mL | 1.9505 mL | 4.8761 mL | |
| 25 mM | 0.1560 mL | 0.7802 mL | 1.5604 mL | 3.9009 mL | |
| 30 mM | 0.1300 mL | 0.6502 mL | 1.3003 mL | 3.2508 mL | |
| 40 mM | 0.0975 mL | 0.4876 mL | 0.9752 mL | 2.4381 mL | |
| 50 mM | 0.0780 mL | 0.3901 mL | 0.7802 mL | 1.9505 mL | |
| 60 mM | 0.0650 mL | 0.3251 mL | 0.6502 mL | 1.6254 mL | |
| 80 mM | 0.0488 mL | 0.2438 mL | 0.4876 mL | 1.2190 mL | |
| 100 mM | 0.0390 mL | 0.1950 mL | 0.3901 mL | 0.9752 mL |
Dapsone-d8 Related Classifications
HY-B0688S Related Classifications
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