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Cat. No.: HY-183140

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DH20931

DH20931 is a ceramide synthase 2 (CerS2) activator. DH20931 inhibits growth of cancer cells by inducing lipotoxic endoplasmic reticulum (ER) stress. DH20931 shows synergistic anti-tumor efficacy with Doxorubicin (HY-15142A). DH20931 can be used for the research of breast cancer.

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CAS No.: 1629992-28-4
Formule: C₂₁H₂₁ClN₂O₂
Masse moléculaire:368.86

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Please store the product under the recommended conditions in the Certificate of Analysis.

DH20931 Chemical Structure

CAS No.: 1629992-28-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Bioz

Activité biologique

Description

IC₅₀ & Target^[2]

Caspase 3

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Cellular Effect

Cell Line	Type	Value	Description	References
BT-474	IC₅₀	0.3 μM Compound: 1c, DH20931	Cytotoxicity against human BT474 cells assessed as growth inhibition after 48 hrs by methylene blue staining-based assay Cytotoxicity against human BT474 cells assessed as growth inhibition after 48 hrs by methylene blue staining-based assay	[PMID: 25240616]

In Vitro

DH20931 potently inhibits the growth of MDA-MB231, MDA-MB468, BT474, MCF7, and T47D cancer cells with IC₅₀ values of 3.9, 1.8, 0.3, 1.3 and 1.0 μM^[1].
DH20931 significantly reduces the required IC₅₀ of Doxorubicin (HY-15142A) by 3-8-fold, resulting in hyper-activation of the UPR, maximized ATF4/CHOP/PUMA expression, and a marked increase in cleaved caspase-3^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1629992-28-4
Masse moléculaire 368.86
Formule C₂₁H₂₁ClN₂O₂
SMILES

COC1=CC=C2C3=C4C5=C(CCN4C=[N+]3CCC2=C1)C=C(C=C5)OC.[Cl-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Jaiswal AS, et al. Anti-tumor activity of novel biisoquinoline derivatives against breast cancers. Bioorg Med Chem Lett. 2014;24(20):4850-4853. [Content Brief]

[2]. Alatawi H, et al. A novel CerS2 activator, DH20931, synergizes with doxorubicin to overcome therapeutic resistance in breast cancer[J]. Cancer Research, 2026, 86(7_Supplement): 4457-4457.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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DH20931

Voir tous les produits spécifiques à Isoform Acyltransferase

Voir tous les produits spécifiques à Isoform Caspase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

DH20931 Related Classifications

HY-183140 Related Classifications