ATF2 - activating transcription factor 2 Gene

Also Known as HB16; CREB2; TREB7; CREB-2; CRE-BP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1386

About ATF2

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:175,072,259-175,168,203 (from NCBI)

This gene has 20 transcripts (splice variants), 214 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 19.6), brain (RPKM 14.7) and 25 other tissues.

Summary

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a Histone Acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

ATF2 Products (6)

mRNA	Protein	Name
NM_001256090.2	NP_001243019.1	cyclic AMP-dependent transcription factor ATF-2 isoform 1
NM_001256091.2	NP_001243020.1	cyclic AMP-dependent transcription factor ATF-2 isoform 2
NM_001256092.2	NP_001243021.1	cyclic AMP-dependent transcription factor ATF-2 isoform 3
NM_001256093.2	NP_001243022.1	cyclic AMP-dependent transcription factor ATF-2 isoform 4
NM_001256094.2	NP_001243023.1	cyclic AMP-dependent transcription factor ATF-2 isoform 5
NM_001880.4	NP_001871.2	cyclic AMP-dependent transcription factor ATF-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16300731	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8798441	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19861239	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	2516827	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19861239	GOA
enables cAMP response element binding	IDA IDA: Inferred from direct assay	19861239	GOA
enables cAMP response element binding protein binding	IDA IDA: Inferred from direct assay	19861239	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	2196176	GOA
enables histone H2B acetyltransferase activity	IDA IDA: Inferred from direct assay	10821277	GOA
enables histone H4 acetyltransferase activity	IDA IDA: Inferred from direct assay	10821277	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16511568	GOA
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	17267404	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8440710	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21098032	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	22304920	GOA
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	15916964	GOA
involved in cellular response to leucine starvation	IDA IDA: Inferred from direct assay	17267404	GOA
involved in mitotic intra-S DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	15916964	GOA
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	28977001	GOA
involved in negative regulation of transcription by RNA polymerase II	EXP EXP: Inferred from Experiment	11231009	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	17267404	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	10821277	GOA
involved in positive regulation of cardiac muscle myoblast proliferation	IDA IDA: Inferred from direct assay	22982025	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28977001	GOA
involved in positive regulation of mitochondrial membrane permeability involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	22304920	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16300731	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	22304920	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19861239	GOA
involved in response to osmotic stress	IDA IDA: Inferred from direct assay	21098032	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	10821277	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of H4 histone acetyltransferase complex	IDA IDA: Inferred from direct assay	10821277	GOA
part of RNA polymerase II transcription regulator complex	EXP EXP: Inferred from Experiment	11231009	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
located in chromatin	IDA IDA: Inferred from direct assay	23729669	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22304920	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	22304920	GOA
located in nucleus	EXP EXP: Inferred from Experiment	11231009	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8798441	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	15916964	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATF2 Protein Structure

bZIP_1

0
100
200
300
400
505 a.a.

Protein Preferred Names	Protein Names
cyclic AMP-dependent transcription factor ATF-2	cAMP response element-binding protein CRE-BP1

ATF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ATF2	P15336	FOS	Homo sapiens	Q6FG41	Y2H Prey Pooling	25416956
Intra	ATF2	P15336	FOS	Homo sapiens	Q6FG41	Validated Y2H	25416956
Intra	ATF2	P15336	FOS	Homo sapiens	Q6FG41	Y2H Array	25416956
Intra	ATF2	P15336	BATF3	Homo sapiens	Q9NR55	Peptide Array	20102225
Intra	ATF2	P15336	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
Intra	ATF2	P15336	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	ATF2	P15336	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
Intra	ATF2	P15336	JUN	Homo sapiens	P05412	Anti Tag CoIP	33961781
Intra	ATF2	P15336	JUN	Homo sapiens	P05412	Anti Tag CoIP	28514442
Intra	ATF2	P15336	JUN	Homo sapiens	P05412	FRET	23661758
Intra	ATF2	P15336	JUN	Homo sapiens	P05412	PLA	20511396
Intra	ATF2	P15336	JUN	Homo sapiens	P05412	Display Tech	20195357
Intra	ATF2	P15336	FOS	Homo sapiens	P01100	Peptide Array	20102225
Intra	ATF2	P15336	JUN	Homo sapiens	P05412	TAP	20195357
Intra	ATF2	P15336	JUN	Homo sapiens	P05412	CoIP	10327051
Intra	ATF2	P15336	JUN	Homo sapiens	P05412	Peptide Array	20102225
Intra	ATF2	P15336	BACH1	Homo sapiens	O14867	FRET	23661758
Intra	ATF2	P15336	BACH1	Homo sapiens	O14867	Peptide Array	20102225
Intra	ATF2	P15336	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	ATF2	P15336	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	ATF2	P15336	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	ATF2	P15336	VRK1	Homo sapiens	Q99986	Anti Tag CoIP	15105425
Intra	ATF2	P15336	VRK1	Homo sapiens	Q99986	IF	15105425
Intra	ATF2	P15336	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
Intra	ATF2	P15336	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	ATF2	P15336	RNF4	Homo sapiens	P78317	Validated Y2H	32296183
Intra	ATF2	P15336	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	ATF2	P15336	CENPQ	Homo sapiens	Q7L2Z9	Validated Y2H	32296183
Intra	ATF2	P15336	CENPQ	Homo sapiens	Q7L2Z9	Y2H Array	32296183
Intra	ATF2	P15336	CITED1	Homo sapiens	Q99966	CoIP	10327051
Intra	ATF2	P15336	JUND	Homo sapiens	P17535	Anti Tag CoIP	33961781
Intra	ATF2	P15336	JUND	Homo sapiens	P17535	Anti Tag CoIP	28514442
Intra	ATF2	P15336	JUND	Homo sapiens	P17535	Peptide Array	20102225
Intra	ATF2	P15336	FOSB	Homo sapiens	P53539	Validated Y2H	32296183
Intra	ATF2	P15336	FOSB	Homo sapiens	P53539	Y2H Prey Pooling	32296183
Intra	ATF2	P15336	FOSB	Homo sapiens	P53539	Y2H Array	32296183
Intra	ATF2	P15336	SPOPL	Homo sapiens	Q6IQ16	Validated Y2H	32296183
Intra	ATF2	P15336	SPOPL	Homo sapiens	Q6IQ16	Y2H Array	32296183
Intra	ATF2	P15336	SPOPL	Homo sapiens	Q6IQ16	Y2H Prey Pooling	32296183
Intra	ATF2	P15336	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	ATF2	P15336	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	ATF2	P15336	EXOSC8	Homo sapiens	Q96B26	Y2H Array	25416956
Intra	ATF2	P15336	EXOSC8	Homo sapiens	Q96B26	Validated Y2H	25416956
Intra	ATF2	P15336	FOSL2	Homo sapiens	P15408	Y2H Prey Pooling	32296183
Intra	ATF2	P15336	FOSL2	Homo sapiens	P15408	Peptide Array	20102225
Intra	ATF2	P15336	FOSL2	Homo sapiens	P15408	Validated Y2H	32296183
Intra	ATF2	P15336	FOSL2	Homo sapiens	P15408	Y2H Array	32296183
Intra	ATF2	P15336	ATF4	Homo sapiens	P18848	FRET	23661758
Intra	ATF2	P15336	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
Intra	ATF2	P15336	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
Intra	ATF2	P15336	SYT-SSX2	Homo sapiens	A4PIW0	Anti Bait CoIP	22439931
Intra	ATF2	P15336	SYT-SSX2	Homo sapiens	A4PIW0	Anti Tag CoIP	22439931
Intra	ATF2	P15336	NFATC1	Homo sapiens	O95644	Pull Down	25609649
Intra	ATF2	P15336	ATF3	Homo sapiens	P18847	FRET	23661758
Intra	ATF2	P15336	ATF3	Homo sapiens	P18847	Peptide Array	20102225
Intra	ATF2	P15336	MAPK9	Homo sapiens	P45984	Y2H Array	31515488
Intra	ATF2	P15336	MAPK9	Homo sapiens	P45984	Y2H Prey Pooling	25416956
Intra	ATF2	P15336	MAPK9	Homo sapiens	P45984	Validated Y2H	25416956
Intra	ATF2	P15336	MAPK9	Homo sapiens	P45984	Y2H Prey Pooling	32296183
Intra	ATF2	P15336	MAPK9	Homo sapiens	P45984	Validated Y2H	32296183
Intra	ATF2	P15336	MAPK9	Homo sapiens	P45984	Y2H Array	25416956
Intra	ATF2	P15336	MAPK9	Homo sapiens	P45984	Y2H Array	32296183
Intra	ATF2	P15336	CEBPG	Homo sapiens	P53567	Peptide Array	20102225
Intra	ATF2	P15336	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
Intra	ATF2	P15336	FOSL1	Homo sapiens	P15407	FRET	23661758
Intra	ATF2	P15336	JUNB	Homo sapiens	P17275	Anti Tag CoIP	33961781
Intra	ATF2	P15336	JUNB	Homo sapiens	P17275	Complementation	16511568
Intra	ATF2	P15336	BATF	Homo sapiens	Q16520	FRET	23661758
Intra	ATF2	P15336	ATF7	Homo sapiens	P17544	Peptide Array	20102225
Intra	ATF2	P15336	ATF7	Homo sapiens	P17544	Anti Tag CoIP	33961781
Intra	ATF2	P15336	SUMO1	Homo sapiens	P63165	Y2H Array	32296183
Intra	ATF2	P15336	SUMO1	Homo sapiens	P63165	Validated Y2H	32296183
Intra	ATF2	P15336	SUMO1	Homo sapiens	P63165	Y2H Prey Pooling	32296183
Intra	ATF2	P15336	LHX8	Homo sapiens	Q68G74	Y2H Prey Pooling	32296183
Intra	ATF2	P15336	LHX8	Homo sapiens	Q68G74	Validated Y2H	32296183
Intra	ATF2	P15336	LHX8	Homo sapiens	Q68G74	Y2H Array	32296183
Intra	ATF2	P15336	FOS	Homo sapiens	P01100	TAP	20195357
Intra	ATF2	P15336	FOS	Homo sapiens	P01100	Y2H Array	32296183
Intra	ATF2	P15336	FOS	Homo sapiens	P01100	Y2H Prey Pooling	32296183
Cross	ATF2	P15336	MDV005	Gallid herpesvirus 2	Q9DGW5	Peptide Array	20102225
Cross	ATF2	P15336	HBZ	Human T-cell leukemia virus 1	P0C746	Peptide Array	20102225

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATF2 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P74408	ATF2 Protein, Human (sf9, His-GST)	P15336 (M1-S505)	≥ 80%, as determined by reducing SDS-PAGE.

ATF2 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P80552	ATF2 Antibody (YA606)	WB	Human, Mouse, Rat
HY-P80552A	ATF2 Antibody (YA606)(PBS only)	WB	Human, Mouse, Rat
HY-P80793	Phospho-ATF2 (Thr71) Antibody (YA224)	WB, ICC/IF, IP	Human, Mouse
HY-P80793A	Phospho-ATF2 (Thr71) Antibody (YA224)(PBS only)	WB, ICC/IF, IP	Human, Mouse
HY-P85048	ATF-2 Antibody (YA4740)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Cardiomyopathy, Familial Hypertrophic, 25	Hypertrophic Cardiomyopathy 25 CMH25 Cardiomyopathy, Hypertrophic, 25 Cardiomyopathy Familial Hypertrophic 25 Cardiomyopathy, Familial Hypertrophic 25 Cardiomyopathy, Hypertrophic, Type 25
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Epidermolysis Bullosa Simplex	Ebs Epidermolysis Bullosa Intraepidermic Epidermolytic Epidermolysis Bullosa
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 1 PKD1 Adpkd Polycystic Kidney Disease, Adult, Type I Apkd1 Potter Type Iii Polycystic Kidney Disease Polycystic Kidney Disease, Adult Potter Type Iii Polycystic Kidney Disease, Formerly Polycystic Kidney Disease, Type 1 Adpkd1 Adult Polycystic Kidney Disease Type 1 Autosomal Dominant Polycystic Kidney Disease 1 Pkd-1 Polycystic Kidney Disease Adult Polycystic Kidney Disease Type I Polycystic Kidneys Polycystic Kidney Disease, Adult Type I Polycystic Kidney Type 1 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 1 Polycystic Kidney, Autosomal Dominant Polycystic Kidney, Type 1 Autosomal Dominant Disease Polycystic Kidney Diseases
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-B1198	Piperonyl butoxide	Inhibitor	98.0%	Unkown
HY-B1198R	Piperonyl butoxide (Standard)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-13241A	Ralimetinib	Inhibitor	98.58%	Phase 2
HY-152860	Darizmetinib		99.94%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-13241	Ralimetinib dimesylate		99.97%	Unkown
HY-134963	SBI-0087702		99.55%	Unkown
HY-117987	CPS-11		99.39%	Unkown
HY-B1198S	Piperonyl butoxide-d9	Inhibitor	98.68%	Unkown
HY-RS01128	ATF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W585976	Benzo[a]pyrene diol epoxide		/	Unkown
HY-180419	SF-3-030		/	Unkown
HY-RS05361	GDNF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-107091R	Aspartyl-alanyl-diketopiperazine (Standard)	Inhibitor	/	Unkown
HY-RS17003	Atf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23446	Atf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATF2	VGNC	VGNC:68500
Macaca mulatta	ATF2	VGNC	VGNC:70169
Bos taurus	ATF2	VGNC	VGNC:26240
Mus musculus	ATF2	MGD	MGI:109349
Rattus norvegicus	ATF2	RGD	RGD:621862
Canis familiaris	ATF2	VGNC	VGNC:38208
Others	ATF2	NCBI