Narasin
Based on 2 publication(s) in Google Scholar
Narasin is a cationic ionophore antibiotic and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin has antimicrobial, antiviral anticancer activity. Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF-β/SMAD3 and IL‑6/STAT3 signaling pathways.
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- Pureté: 88.0%
- CAS No.: 55134-13-9
- Formule: C43H72O11
- Masse moléculaire:765.03
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Stockage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Narasin
MoreVoir tous les produits spécifiques à Isoform Parasite
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Activité biologique
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Coccidia |
Narasin (1-25 ng/mL, 48 h) increases the percentage of phosphatidylserine exposing erythrocytes, cytosolic Ca2+ activity ([Ca2+]i) and the ceramide abundance at the erythrocyte surface[1].
Narasin (0-10 μM, 72 h) inhibits DENV2 infection with an IC50 value of 0.39 μM[2].
Narasin (0-10 μM, 72 h) significantly inhibits the cell viability of MCF-7, T47D and MDA-MB-231 cells, with respective IC50 values of 2.219, 3.562 and 11.76 µM[3].
Narasin (2.5-5 µM, 24 h) inhibits cell migration and invasion by suppressing EMT in ER+ BC cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, T47D, MDA-MB-231
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Concentration:0-10 μM
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Incubation Time:72 h
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Result:Significantly reduced the viability of MCF-7 and T47D cells, with IC50 values of 2.219 and 3.562 µM, respectively.
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Cell Line:MCF-7 and T47D cells
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Concentration:2.5-5 µM
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Incubation Time:72 h
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Result:Significantly inhibited the migration of MCF-7 and T47D cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Xenograft mice model with MCF-7 cells
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Dosage:0.5 mg/kg or 1.5 mg/kg
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Administration:i.p., every 2 days for 50 consecutive days
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Result:Significantly decreased tumor volume and tumor weight in xenograft mice model with MCF-7 cells.
Chemical Information
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CAS No. 55134-13-9
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Appearance Solid
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Masse moléculaire 765.03
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Formule C43H72O11
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Color White to off-white
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SMILES
O[C@H]1[C@@]2(O[C@](C)([C@]3([H])O[C@H]([C@](CC)(O)CC3)C)CC2)O[C@@]4(O[C@]([C@@H](C)C[C@H]4C)([H])[C@@H](CC)C([C@@H](C)[C@@H](O)[C@@H]([C@]5([H])O[C@@]([C@@H](C)C[C@@H]5C)([H])[C@@H](CC)C(O)=O)C)=O)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Rep
Controlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity. [Abstract]2025 Jul 22;44(7):115922. PMID: 40628273 -
Talanta
Fluorescence-activated cell sorting-based efficient screening of monensin monoclonal antibodies and applications in lateral flow immunoassay. [Abstract]2025 Apr 10:293:128128. PMID: 40222095
Solvant et solubilité
DMSO : 12.5 mg/mL (16.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (279 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Portuguese - PT (419 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Ghada Bouguerra, et al. Stimulation of Eryptosis by Narasin. Cell Physiol Biochem. 2015;37(5):1807-16. [Content Brief]
[2]. Low JS, et al. Narasin, a novel antiviral compound that blocks dengue virus protein expression. Antivir Ther. 2011;16(8):1203-18. [Content Brief]
[3]. Chen J, et al. Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF‑β/SMAD3 and IL‑6/STAT3 signaling pathways. Mol Med Rep. 2020 Dec;22(6):5113-5124. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3071 mL | 6.5357 mL | 13.0714 mL | 32.6785 mL |
| 5 mM | 0.2614 mL | 1.3071 mL | 2.6143 mL | 6.5357 mL | |
| 10 mM | 0.1307 mL | 0.6536 mL | 1.3071 mL | 3.2678 mL | |
| 15 mM | 0.0871 mL | 0.4357 mL | 0.8714 mL | 2.1786 mL |
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