Obtusifoliol
Based on 1 publication(s) in Google Scholar
Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with Kd values of 1.2 μM and 1.4 μM for Trypanosoma brucei (TB) and human CYP51, respectively.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.86%
- CAS No.: 16910-32-0
- Formule: C30H50O
- Masse moléculaire:426.72
-
Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Obtusifoliol
MoreVoir tous les produits spécifiques à Isoform Parasite
More
Activité biologique
|
CYP51 |
Trypanosoma |
Obtusifoliol (0.1-100 μM; 48 hours) inhibit MCF-7 and MDA-MB231 breast cancer cells proliferation via arresting cell cycle progression and induction of apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF-7; MDA-MB231 breast cancer cells
-
Concentration:0.1, 1, 10, 40, 80, and 100 µM
-
Incubation Time:48 hours
-
Result:Inhibited MCF-7 and MDA-MB231 breast cancer cells proliferation.
Chemical Information
-
CAS No. 16910-32-0
-
Appearance Solid
-
Masse moléculaire 426.72
-
Formule C30H50O
-
Color White to off-white
-
SMILES
C=C(C(C)C)CC[C@@H](C)[C@H]1CC[C@@]2(C)C(CC[C@@]3([H])[C@H](C)[C@@H](O)CC[C@]43C)=C4CC[C@]12C
-
Structure Classification
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
-
Journal Impact Factor
-
Most Recent
Pureté et documentation
-
Fiche technique (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. Lepesheva GI, et al. CYP51 from Trypanosoma brucei is obtusifoliol-specific.Biochemistry. 2004 Aug 24;43(33):10789-99. [Content Brief]
[2]. Aghaei M, et al Obtusifoliol related steroids from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231). Steroids. 2016 Nov;115:90-97. doi: 10.1016/j.steroids.2016.07.008. Epub 2016 Jul 26. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Obtusifoliol Related Classifications
HY-N7266 Related Classifications
Powered by Bioz