Cat. No.: HY-N1103

Vasicine

(Synonyms: Peganine)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Vasicine (peganine) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine activates PI3K/Akt signaling pathway, exhibits antioxidant, anti-inflammatory and antibacterial activities.

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Pureté: 98.80%
CAS No.: 6159-55-3
Formule: C₁₁H₁₂N₂O
Masse moléculaire:188.23

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Vasicine Chemical Structure

CAS No.: 6159-55-3

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Activité biologique
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform PI3K :

Voir tous les produits spécifiques à Isoform Akt :

Cellular Effect

Cell Line	Type	Value	Description	References
PC-3	IC₅₀	15.41 μM Compound: 11b	Cytotoxicity against human PC3 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability by MTT assay	[PMID: 29229205]

In Vitro

Vasicine (10-100 μg/mL, 10 min) exhibits a moderate inhibitory activity against H+/K+-ATPase (IC₅₀=73.47 μg/mL), scavenges DPPH free radical (IC₅₀=71.97 μg/mL), reduces gastric acid secretion and exhibits anti-ulcer effect^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vasicine (2.5-10 mg/kg, po, once daily for 7 days) improves the cardiac function, inhibits myocardial cell apoptosis, and alleviates myocardial necrosis, edema, and inflammatory cell infiltration in Isoproterenol (HY-B0468)-induced rats myocardial infarction models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Isoproterenol-induced rats myocardial infarction models^[2]
Dosage:

2.5-10 mg/kg
Administration:

po, once daily for 7 days
Result:

Reduced the levels of serum lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB).
Increased left ventricular systolic pressure (LVSP) and myocardial contractility, and reduced infarct size.
Reduced the levels of serum TNF-α and IL-6.
Increased the activities of SOD and glutathione peroxidase (GPx) in myocardial tissue, reduced the levels of MDA and MPO.
Increased the thickness of the left ventricular posterior wall and the left ventricular mass.
Inhibited myocardial cell apoptosis.

Chemical Information

CAS No. 6159-55-3
Appearance Solid
Masse moléculaire 188.23
Formule C₁₁H₁₂N₂O
Color White to off-white
SMILES

O[C@H]1CCN2C1=NC3=C(C=CC=C3)C2
Synonyms

Peganine
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
- Plants
- Acanthaceae
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Neuropharmacology

Novel mechanism of hypidone hydrochloride (YL-0919) in Parkinson's disease: inhibiting neuronal ferroptosis by targeting the Sigma1R-PI3K-AKT-ACSL4 axis. [Abstract]

2026 Jul 1:292:110950. PMID: 41887568
Cell Signal

IFI6 regulation of physiological functions in granulosa cells. [Abstract]

2026 Apr:140:112348. PMID: 41519217

Solvant et solubilité

In Vitro:

DMSO : 83.33 mg/mL (442.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.3126 mL

26.5632 mL

53.1265 mL

5 mM

1.0625 mL

5.3126 mL

10.6253 mL

10 mM

0.5313 mL

2.6563 mL

5.3126 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (13.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (13.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (13.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Grange JM, et al. Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. J Ethnopharmacol. 1996 Jan;50(1):49-53. [Content Brief]

[2]. Jiang T, et al., Protective Effect Of Vasicine Against Myocardial Infarction In Rats Via Modulation Of Oxidative Stress, Inflammation, And The PI3K/Akt Pathway. Drug Des Devel Ther. 2019 Oct 31;13:3773-3784. [Content Brief]

[3]. Singh VK, et al., Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers. Phytomedicine. 2013 Oct 15;20(13):1180-5. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.3126 mL	26.5632 mL	53.1265 mL	132.8162 mL
	5 mM	1.0625 mL	5.3126 mL	10.6253 mL	26.5632 mL
	10 mM	0.5313 mL	2.6563 mL	5.3126 mL	13.2816 mL
	15 mM	0.3542 mL	1.7709 mL	3.5418 mL	8.8544 mL
	20 mM	0.2656 mL	1.3282 mL	2.6563 mL	6.6408 mL
	25 mM	0.2125 mL	1.0625 mL	2.1251 mL	5.3126 mL
	30 mM	0.1771 mL	0.8854 mL	1.7709 mL	4.4272 mL
	40 mM	0.1328 mL	0.6641 mL	1.3282 mL	3.3204 mL
	50 mM	0.1063 mL	0.5313 mL	1.0625 mL	2.6563 mL
	60 mM	0.0885 mL	0.4427 mL	0.8854 mL	2.2136 mL
	80 mM	0.0664 mL	0.3320 mL	0.6641 mL	1.6602 mL
	100 mM	0.0531 mL	0.2656 mL	0.5313 mL	1.3282 mL

Keywords

Vasicine

2 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Vasicine

Voir tous les produits spécifiques à Isoform PI3K

Voir tous les produits spécifiques à Isoform Akt

Activité biologique

Chemical Information

Publications (2)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Vasicine Related Classifications

HY-N1103 Related Classifications