PRO-HD2
PRO-HD2 is a HDAC6 PROTAC degrader. PRO-HD2 exerts antiproliferative activity in leukemia cells. PRO-HD2 can be used for leukemia research.
(Pink: HDAC6 ligand (HY-175627); Blue: Cereblon ligand (HY-41547); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3126555-89-0
- Formula: C38H39N5O5S
- Molecular Weight:677.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
HDAC6 |
Cereblon |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells (adenocarcinomic human alveolar basal epithelial cells)
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Concentration:500 nM, 1 μM, 5 μM
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Incubation Time:24 h
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Result:Nearly completely depleted HDAC6 protein.
Exhibited higher HDAC6 degradation efficiency compared to PRO-HD1 and PRO-HD3.
Chemical Information
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CAS No. 3126555-89-0
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Molecular Weight 677.81
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Formula C38H39N5O5S
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SMILES
S=C1N(CC2=CC=C(C3=CC=C(CNCCCCCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)C=C3)C=C2)C=CC=C1O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PRO-HD2 Related Classifications
HY-155397 Related Classifications
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