EGFR/CDK2-IN-3
EGFR/CDK2-IN-3 (compound 4b) is a dual inhibitor of EGFR and CDK-2 with IC50s of 71.7 and 113.7 nM, respectively. EGFR/CDK2-IN-3 induces apoptosis in MCF-7 cells and arrests the cell cycle in the S phase. EGFR/CDK2-IN-3 has significant anti-cancer cell toxicity and inhibits MCF-7 with an IC50 of 3.16 μM.
For research use only. We do not sell to patients.
- Formula: C30H20N6OS
- Molecular Weight:512.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
IC50: 71.7 (EGFR), 113.7 nM (CDK-2)[1]
Chemical Information
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Molecular Weight 512.58
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Formula C30H20N6OS
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SMILES
O=C(C1=CN(C2=CC=CC=C2)N=C1C3=NN4C(SC3)=NN=C4C5=CC=CC=C5)C6=CC=C7C=CC=CC7=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR/CDK2-IN-3 Related Classifications
HY-156115 Related Classifications
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