Lasalocid
Based on 4 publication(s) in Google Scholar
Lasalocid (Lasalocid-A) is an antibacterial and anticoccidial agent that can be used as feed additives. Lasalocid exhibits antitumor activity. Lasalocid is orally active.
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- Pureza: 97.19%
- No. CAS: 25999-31-9
- Fòrmula: C34H54O8
- Peso molecular:590.79
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Lasalocid
MoreVer todos los productos específicos de isoformas Antibiotic
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.8 μM
Compound: 1, Lasalocid
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
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[PMID: 23932361] |
| BALB/3T3 | IC50 |
7.35 μM
Compound: 1, Lasalocid
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Cytotoxicity against mouse BALB/3T3 cells after 72 hrs by SRB assay
Cytotoxicity against mouse BALB/3T3 cells after 72 hrs by SRB assay
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[PMID: 23932361] |
| HeLa | EC50 |
2 μM
Compound: Lasalocid
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Inhibition of Escherichia coli Stx1 in human HeLa cells assessed as stimulation of protein synthesis by measuring increase in [14C]-leucine incorporation incubated with cells for 3 hrs prior to Stx1 addition and further incubated for overnight and subsequ
Inhibition of Escherichia coli Stx1 in human HeLa cells assessed as stimulation of protein synthesis by measuring increase in [14C]-leucine incorporation incubated with cells for 3 hrs prior to Stx1 addition and further incubated for overnight and subsequ
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[PMID: 32648758] |
| HT-29 | IC50 |
1.95 μM
Compound: 1, Lasalocid
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Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
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[PMID: 23932361] |
| MCF7 | IC50 |
3.12 μM
Compound: 1, Lasalocid
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Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
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[PMID: 23932361] |
| P388 | IC50 |
4.54 μM
Compound: 1, Lasalocid
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Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay
Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay
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[PMID: 23932361] |
Lasalocid (2.5 μg/mL) inhibits the growth of white spot bacteria, yellow spot bacteria, and fibrinolytic vibrio[1].
Lasalocid works in the rumen by selectively promoting the growth of succinate-producing Bacteroides and S. ruminantium, which can lead to an increased formation of propionate in the rumen[1].
Lasalocid (0-5 μM, 24-48 h) inhibits proliferations of cancer cells PC-3 and LNCaP, arrests the cell cycle at G0/G1 phase, induces apoptosis and autophagy in PC-3 cell[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pneumocystis carinii-infected rats models[3]
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Dosage:5-20 mg/kg/day
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Administration:po, administrated by food, 4 weeks
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Result:Prevented P. carinii pneumonia.
Chemical Information
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No. CAS 25999-31-9
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Appearance Solid
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Peso molecular 590.79
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Fòrmula C34H54O8
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Color White to off-white
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SMILES
O=C(O)C1=C(CC[C@@H](C)[C@H](O)[C@H](C)C([C@@H]([C@H]2O[C@@]([C@H]3CC[C@](O)(CC)[C@H](C)O3)(CC)C[C@@H]2C)CC)=O)C=CC(C)=C1O
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Synonyms
Lasalocid-A; Ionophore X-537A; Antibiotic X-537A
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Structure Classification
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Initial Source
Streptomyces lasaliensis
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (4)
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Journal Impact Factor
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Most Recent
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Talanta
Fluorescence-activated cell sorting-based efficient screening of monensin monoclonal antibodies and applications in lateral flow immunoassay. [Abstract]2025 Apr 10:293:128128. PMID: 40222095 -
Langmuir
Lasalocid Acid Antibiotic at a Membrane Surface Probed by Sum Frequency Generation Spectroscopy. [Abstract]2020 Mar 31;36(12):3184-3192. PMID: 32069059 -
J Cancer
Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways. [Abstract]2025 Jan 1;16(3):765-783. PMID: 39781349 -
Solvente y solubilidad
DMSO : 100 mg/mL (169.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.23 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Chen M, et al. Effect of monensin and lasalocid-sodium on the growth of methanogenic and rumen saccharolytic bacteria. Appl Environ Microbiol. 1979 Jul;38(1):72-7. [Content Brief]
[2]. Kim KY, et al., Lasalocid induces cytotoxic apoptosis and cytoprotective autophagy through reactive oxygen species in human prostate cancer PC-3 cells. Biomed Pharmacother. 2017 Apr;88:1016-1024. [Content Brief]
[3]. OZ HS, et al., Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis. Antimicrob Agents Chemother. 1997 Jan;41(1):191-2. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6926 mL | 8.4632 mL | 16.9265 mL | 42.3162 mL |
| 5 mM | 0.3385 mL | 1.6926 mL | 3.3853 mL | 8.4632 mL | |
| 10 mM | 0.1693 mL | 0.8463 mL | 1.6926 mL | 4.2316 mL | |
| 15 mM | 0.1128 mL | 0.5642 mL | 1.1284 mL | 2.8211 mL | |
| 20 mM | 0.0846 mL | 0.4232 mL | 0.8463 mL | 2.1158 mL | |
| 25 mM | 0.0677 mL | 0.3385 mL | 0.6771 mL | 1.6926 mL | |
| 30 mM | 0.0564 mL | 0.2821 mL | 0.5642 mL | 1.4105 mL | |
| 40 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.0579 mL | |
| 50 mM | 0.0339 mL | 0.1693 mL | 0.3385 mL | 0.8463 mL | |
| 60 mM | 0.0282 mL | 0.1411 mL | 0.2821 mL | 0.7053 mL | |
| 80 mM | 0.0212 mL | 0.1058 mL | 0.2116 mL | 0.5290 mL | |
| 100 mM | 0.0169 mL | 0.0846 mL | 0.1693 mL | 0.4232 mL |
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