Referencia número: HY-N7512

Asimilobine

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Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity.

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Pureza: 99.9%
No. CAS: 6871-21-2
Fòrmula: C₁₇H₁₇NO₂
Peso molecular:267.32

Almacenamiento:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Asimilobine Chemical Structure

No. CAS: 6871-21-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]^[2]

Plasmodium

Dopamine Receptor

serotonergic receptor

Ver todos los productos específicos de isoformas Dopamine Receptor :

Ver todos los productos específicos de isoformas 5-HT Receptor :

Ver todos los productos específicos de isoformas Parasite :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	>20 μg/mL Compound: 1	Cytotoxicity against human A431 cells after 3 days by SRB assay Cytotoxicity against human A431 cells after 3 days by SRB assay	[PMID: 8254346]
HT-1080	ED₅₀	>20 μg/mL Compound: 1	Cytotoxicity against human HT1080 cells after 3 days by SRB assay Cytotoxicity against human HT1080 cells after 3 days by SRB assay	[PMID: 8254346]
KB	ED₅₀	>20 μg/mL Compound: 1	Cytotoxicity against human KB cells after 3 days by SRB assay Cytotoxicity against human KB cells after 3 days by SRB assay	[PMID: 8254346]
KB-V1	ED₅₀	>20 μg/mL Compound: 1	Cytotoxicity against vinblastine-resistant human KBV1 cells after 3 days by SRB assay Cytotoxicity against vinblastine-resistant human KBV1 cells after 3 days by SRB assay	[PMID: 8254346]
LNCaP	ED₅₀	>20 μg/mL Compound: 1	Cytotoxicity against human LNCAP cells after 3 days by SRB assay Cytotoxicity against human LNCAP cells after 3 days by SRB assay	[PMID: 8254346]
P388	ED₅₀	>20 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells after 3 days by SRB assay Cytotoxicity against mouse P388 cells after 3 days by SRB assay	[PMID: 8254346]
SK-MEL-2	ED₅₀	>20 μg/mL Compound: 1	Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay	[PMID: 8254346]
U-373MG ATCC	ED₅₀	>20 μg/mL Compound: 1	Cytotoxicity against human U373 cells after 3 days by SRB assay Cytotoxicity against human U373 cells after 3 days by SRB assay	[PMID: 8254346]
ZR-75-1	ED₅₀	>20 μg/mL Compound: 1	Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay	[PMID: 8254346]

In Vitro

Asimilobine (0.05-0.2 μM; for 24 h) shows a significant inhibition of intracellular dopamine levels in a concentration-dependent manner with an IC₅₀ value of 0.13 μM^[2].
Asimilobine (0.15 μM) inhibits tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities at 24 h^[2].
Asimilobine also decreases TH mRNA levels and intracellular cyclic AMP levels^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 6871-21-2
Appearance Solid
Peso molecular 267.32
Fòrmula C₁₇H₁₇NO₂
Color Off-white to light brown
SMILES

OC1=C(OC)C2=C3C(CCN[C@]3([H])CC4=CC=CC=C24)=C1
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
- Phenols
- Monophenols
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. N Shoji, et al. Asimilobine and Lirinidine, Serotonergic Receptor Antagonists, From Nelumbo Nucifera. J Nat Prod. Jul-Aug 1987;50(4):773-4. [Content Brief]

[2]. Chun-Mei Jin, et al. Effects of Asimilobine on Dopamine Biosynthesis and l-DOPA-induced Cytotoxicity in PC12 Cells. J Asian Nat Prod Res. Jul-Aug 2008;10(7-8):747-55. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Asimilobine

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Ver todos los productos específicos de isoformas Dopamine Receptor

Ver todos los productos específicos de isoformas 5-HT Receptor

Ver todos los productos específicos de isoformas Parasite

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Asimilobine Related Classifications

HY-N7512 Related Classifications