CM-444
CM-444 is inhibitor for HDAC (IC50 is 6 nM-0.6 μM) and DNA methyltransferases (DNMT, IC50 is 1.8-2.3 μM). CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models.
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- No. CAS: 2256079-52-2
- Fòrmula: C27H30N6O5
- Peso molecular:518.56
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Ver todos los productos específicos de isoformas DNA Methyltransferase
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Actividad biológica
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HDAC1 6.55 nM (IC50) |
HDAC10 15 nM (IC50) |
HDAC3 18 nM (IC50) |
HDAC2 51 nM (IC50) |
HDAC5 59 nM (IC50) |
HDAC4 62 nM (IC50) |
HDAC8 83 nM (IC50) |
HDAC9 90 nM (IC50) |
HDAC7 120 nM (IC50) |
HDAC6 531 nM (IC50) |
HDAC11 567.5 nM (IC50) |
DNMT3A 1.8 μM (IC50) |
DNMT1 2.2 μM (IC50) |
DNMT3B 2.3 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| JJN-3 | GI50 |
482 nM
Compound: 12a
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Antiproliferative activity against human JJN-3 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
Antiproliferative activity against human JJN-3 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
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[PMID: 33661013] |
| MM1.S | GI50 |
32 nM
Compound: 12a
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Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
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[PMID: 33661013] |
| NCI-H929 | GI50 |
103 nM
Compound: 12a
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Antiproliferative activity against human NCI-H929 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
Antiproliferative activity against human NCI-H929 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
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[PMID: 33661013] |
Chemical Information
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No. CAS 2256079-52-2
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Peso molecular 518.56
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Fòrmula C27H30N6O5
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SMILES
O=C(C1=CN=C(N2CCC(CNC3=CC(C4=CC=C(C)O4)=NC5=CC(OC)=C(OC)C=C35)CC2)N=C1)NO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CM-444 Related Classifications
HY-163803 Related Classifications
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