dCeMM2
Based on 1 Customer Validation
dCeMM2 (Compound 2) is a molecular glue-type degrader that targets cyclin K. dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex.
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- Pureza: 99.25%
- No. CAS: 296771-07-8
- Fòrmula: C16H11ClN6OS
- Peso molecular:370.82
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
dCeMM2 (2.5 µM, 5 h) inhibits the enzymatic activity of CDK12/13 with a remarkable selectivity over CDK7 in KBM7 cells[1].
dCeMM2 (10 µM, 1 h) results in interactions between CDK12 and DDB1in HEK cells[1].
dCeMM2 (2.5 µM, 0.5-8 h) degrades cyclin K in KBM7 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KBM7 cells
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Concentration:2.5 µM
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Incubation Time:5 h
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Result:Destabilized cyclin K in KBM7 cells.
Chemical Information
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No. CAS 296771-07-8
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Appearance Solid
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Peso molecular 370.82
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Fòrmula C16H11ClN6OS
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Color Light yellow to yellow
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SMILES
O=C(NC1=NC=C(Cl)C=C1)CSC2=NN=C3C(NC4=C3C=CC=C4)=N2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 41.67 mg/mL (112.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling [published correction appears in Nat Chem Biol. 2021 Mar;17(3):361]. Nat Chem Biol. 2020;16(11):1199-1207. [Content Brief]
[3]. Dong G, et al. Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery. J Med Chem. 2021 Aug 12;64(15):10606-10620. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6967 mL | 13.4836 mL | 26.9673 mL | 67.4182 mL |
| 5 mM | 0.5393 mL | 2.6967 mL | 5.3935 mL | 13.4836 mL | |
| 10 mM | 0.2697 mL | 1.3484 mL | 2.6967 mL | 6.7418 mL | |
| 15 mM | 0.1798 mL | 0.8989 mL | 1.7978 mL | 4.4945 mL | |
| 20 mM | 0.1348 mL | 0.6742 mL | 1.3484 mL | 3.3709 mL | |
| 25 mM | 0.1079 mL | 0.5393 mL | 1.0787 mL | 2.6967 mL | |
| 30 mM | 0.0899 mL | 0.4495 mL | 0.8989 mL | 2.2473 mL | |
| 40 mM | 0.0674 mL | 0.3371 mL | 0.6742 mL | 1.6855 mL | |
| 50 mM | 0.0539 mL | 0.2697 mL | 0.5393 mL | 1.3484 mL | |
| 60 mM | 0.0449 mL | 0.2247 mL | 0.4495 mL | 1.1236 mL | |
| 80 mM | 0.0337 mL | 0.1685 mL | 0.3371 mL | 0.8427 mL | |
| 100 mM | 0.0270 mL | 0.1348 mL | 0.2697 mL | 0.6742 mL |
dCeMM2 Related Classifications
HY-144971 Related Classifications
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